The potential of oral vaccines for disease control in wildlife species

Cross, Martin L.; Buddle, Bryce M.; Aldwell, Frank E.

doi:10.1016/j.tvjl.2006.10.005

Cited by 111 publications

(96 citation statements)

References 59 publications

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“…Ideal qualities for a practical wildlife vaccine include that the vaccine is stable, the delivered material is safe and remains effective in conjunction with the baiting system of choice, and the deployed baited vaccine has a high uptake rate in the target species (Cross et al, 2007a). Most commonly for oral wildlife vaccines, the vaccine itself is delivered inside a separate bait, as is the case with existing rabies and classical swine fever wildlife vaccines (Kaden et al, 2003;Blackwell et al, 2004), as well as prototypical vaccines for plague (Creekmore et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

“…Vaccination of wildlife is one means of controlling Tb, but vaccines applied to wildlife species are most expediently delivered as oral vaccines (Cross et al, 2007a). Examples where this approach has proved successful in reducing disease prevalence include oral rabies vaccination programs among mesocarnivores in Europe and North America (Rupprecht et al, 2004) and oral vaccination against classical swine fever among wild boar in northern Europe (Blome et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

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Lipid-Formulated BCG as an Oral-Bait Vaccine for Tuberculosis: Vaccine Stability, Efficacy, and Palatability to Brushtail Possums (Trichosurus Vulpecula) in New Zealand

Cross

Henderson²,

Lambeth

et al. 2009

Journal of Wildlife Diseases

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ABSTRACT:Bovine tuberculosis (Tb), due to infection with virulent Mycobacterium bovis, represents a threat to New Zealand agriculture due to vectorial transmission from wildlife reservoir species, principally the introduced Australian brushtail possum (Trichosurus vulpecula). An oraldelivery wildlife vaccine has been developed to immunize possums against Tb, based on formulation of the human Tb vaccine (M. bovis BCG) in edible lipid matrices. Here BCG bacilli were shown to be stable in lipid matrix formulation for over 8 mo in freezer storage, for 7 wk under room temperature conditions, and for 3-5 wk under field conditions in a forest/pasture margin habitat (when maintained in weatherproof bait-delivery sachets). Samples of the lipid matrix were flavored and offered to captive possums in a bait-preference study: a combination of 10% chocolate powder with anise oil was identified as the most effective attractant/palatability combination. In a replicated field study, 85-100% of wild possums were shown to access chocolate-flavored lipid pellets, when baits were applied to areas holding approximately 600-800 possums/km 2 . Finally, in a controlled vaccination/challenge study, chocolate-flavored lipid vaccine samples containing 10 8 BCG bacilli were fed to captive possums, which were subsequently challenged via aerosol exposure to virulent M. bovis: vaccine immunogenicity was confirmed, and protection was identified by significantly reduced postchallenge weight loss in vaccinated animals compared to nonvaccinated controls. These studies indicate that, appropriately flavored, lipid delivery matrices may form effective bait vaccines for the control of Tb in wildlife.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Lipid-Formulated BCG as an Oral-Bait Vaccine for Tuberculosis: Vaccine Stability, Efficacy, and Palatability to Brushtail Possums (Trichosurus Vulpecula) in New Zealand

Cross

Henderson²,

Lambeth

et al. 2009

Journal of Wildlife Diseases

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“…Oral vaccination offers a prospective tool for controlling a variety of wildlife diseases (Cross et al 2007;Artois et al 2011). The most notable successes with wildlife vaccination have been the European and North American campaigns against rabies (Cross et al 2007;Sterner et al 2009;Artois et al 2011).…”

mentioning

confidence: 99%

“…The most notable successes with wildlife vaccination have been the European and North American campaigns against rabies (Cross et al 2007;Sterner et al 2009;Artois et al 2011). Mass oral vaccination of wildlife relies on availability of effective immunogens and suitable bait delivery technology (Cross et al 2007;Artois et al 2011).…”

mentioning

confidence: 99%

Using Off-the-Shelf Technologies to Mass Manufacture Oral Vaccine Baits for Wildlife

Corro

Tripp

Stelting

et al. 2017

Journal of Wildlife Diseases

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“…To manage the disease more effectively, we need to understand the potential role of all these factors, including any synergistic effects. We also need to recognize that their relative importance is likely to vary between different areas because of differences in host-community composition and abundance, husbandry practices, landscape factors [56] and climatic conditions, which might affect the survival of bacilli in the environment [57].Vaccination might provide some assistance in the control of bTB in host communities in Britain in the future [58,59], but this as yet untested approach should not be seen as the answer to the bTB problem. Although a badger vaccine might well contribute considerably to our ability to control bTB in the future, history has taught us that there are no 'silver bullets' when it comes to bTB eradication.…”

mentioning

confidence: 99%

Control of bovine tuberculosis in British livestock: there is no ‘silver bullet’

White

Böhm

Marion

et al. 2008

Trends in Microbiology

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Bovine tuberculosis (bTB; Mycobacterium bovis) is a bacterial infection of cattle that also affects certain wildlife species. Culling badgers (Meles meles), the principal wildlife host, results in perturbation of the badger population and an increased level of disease in cattle. Therefore, the priority for future management must be to minimize the risk of disease transmission by finding new ways to reduce the contact rate among the host community. At the farm level, targeting those individuals that represent an elevated risk of transmission might prove to be effective. At the landscape level, risk mapping can provide the basis for targeted surveillance of the host community. Here, we review the current evidence for bTB persistence in Britain and make recommendations for future management and research. Wildlife hosts for bovine tuberculosisMany infections of humans and their livestock are able to cross-infect multiple host species [1]. The presence of infections within a multiple-host community can complicate attempts to reduce disease [2,3], not only because of varying resistance to infection between the different host species but also because of ecological and behavioural differences.Bovine tuberculosis (bTB; Mycobacterium bovis) persists in various countries in the developed world. In some of these countries (including Britain, Ireland and New Zealand), the presence of additional wildlife hosts for the infection -principally Eurasian badgers (Meles meles) in the UK and Ireland, and brush-tailed possums (Trichosurus vulpecula) and ferrets (Mustela putorius) in New Zealand -is thought to have contributed to the persistence of the disease in cattle, despite considerable investment in culling programmes to reduce the populations of these wildlife hosts. Badgers are particularly well suited as a host for bTB because they are a group-living animal. They exhibit a range of social structures, with social group size varying between two individuals in Poland and 25 individuals in Britain, and group territories ranging from 0.14 km 2 in Britain to 14 km 2 in Poland and Finland [4].In Britain, the total economic costs associated with bTB between 2004 and 2011 are expected to reach £1 billion [5]. A test-and-slaughter strategy to detect and remove bTB-infected cattle from British herds had all but eradicated bovine bTB in a large part of Britain by the 1970s, and persistent infection was limited to distinct areas in southwest Britain. Since that time, badgers have been implicated increasingly in the persistence and reemergence of bTB as the disease has spread once more into new areas, both within southwest Britain and beyond.A large-scale field trial, the Randomized Badger Culling Trial (RBCT), was initiated in 1999 to determine the extent of badger involvement in bTB in cattle and the effectiveness of culling badgers in reducing bTB infection in cattle [6,7]. The field trial showed that badger culling over 100-km 2 areas could result in a decrease in cattle bTB inside these areas, with effectiveness increasing with distan...

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The potential of oral vaccines for disease control in wildlife species

Cited by 111 publications

References 59 publications

Lipid-Formulated BCG as an Oral-Bait Vaccine for Tuberculosis: Vaccine Stability, Efficacy, and Palatability to Brushtail Possums (Trichosurus Vulpecula) in New Zealand

Lipid-Formulated BCG as an Oral-Bait Vaccine for Tuberculosis: Vaccine Stability, Efficacy, and Palatability to Brushtail Possums (Trichosurus Vulpecula) in New Zealand

Using Off-the-Shelf Technologies to Mass Manufacture Oral Vaccine Baits for Wildlife

Control of bovine tuberculosis in British livestock: there is no ‘silver bullet’

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