Using Off-the-Shelf Technologies to Mass Manufacture Oral Vaccine Baits for Wildlife

Corro, Lucila M.; Tripp, Daniel W.; Stelting, Scott; Miller, Michael W.

doi:10.7589/2017-01-013

Cited by 8 publications

(9 citation statements)

References 11 publications

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“…Promising preliminary results from field trials conducted throughout the western US have motivated interest in beginning sustained, large-scale field experiments to more fully assess oral vaccination as a prairie dog and black-footed ferret conservation tool (Johnson et al 2014). Benchtop methods for producing vaccine and vaccine-laden baits could not supply these larger field experiments (Corro et al 2017). Consequently, we secured approval from the US Department of Agriculture Center for Veterinary Biologics (CVB) and USGS to have some RCN-F1/ V307 production transferred to a CVBlicensed bulk manufacturer.…”

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confidence: 99%

“…Consequently, we secured approval from the US Department of Agriculture Center for Veterinary Biologics (CVB) and USGS to have some RCN-F1/ V307 production transferred to a CVBlicensed bulk manufacturer. We also have used off-the-shelf technology to mass-produce vaccine-laden baits suitable for mechanized delivery (Corro et al 2017). …”

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confidence: 99%

“…Vaccine-laden baits were manufactured as described by Corro et al (2017;see Supplementary Material). Baits consisted of distilled water, peanut butter, FD&C Blue #1 food dye, a gelatin-based biopolymer matrix (Incortrixt, FoodSource Lure Corporation, Birmingham, Alabama, USA; FoodSource Lure Corporation 2013), and the experimental vaccine (Yersinia Pestis Vaccine, Live Raccoon Poxvirus Vector, Code 11Y2.R0, Colorado Serum Company, Denver, Colorado, USA).…”

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confidence: 99%

“…landscape-scale field assessments of RCN-F1/ V307 launched in 2016 (US Fish and Wildlife Service 2016; Corro et al 2017). The transition from benchtop to larger-scale production increased vaccine bait output by .10-fold from the outset (Corro et al 2017), facilitating bait application across .2,500 ha.…”

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confidence: 99%

“…The transition from benchtop to larger-scale production increased vaccine bait output by .10-fold from the outset (Corro et al 2017), facilitating bait application across .2,500 ha. As part of the transition from custom to mass production, we wanted to assure that changes in vaccine or bait production had not inadvertently compromised immunogenicity.…”

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confidence: 99%

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Responses of Juvenile Black-tailed Prairie Dogs (Cynomys ludovicianus) to a Commercially Produced Oral Plague Vaccine Delivered at Two Doses

Cárdenas-Canales

Wolfe

Tripp

et al. 2017

Journal of Wildlife Diseases

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confidence: 99%

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confidence: 99%

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confidence: 99%

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confidence: 99%

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confidence: 99%

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Responses of Juvenile Black-tailed Prairie Dogs (Cynomys ludovicianus) to a Commercially Produced Oral Plague Vaccine Delivered at Two Doses

Cárdenas-Canales

Wolfe

Tripp

et al. 2017

Journal of Wildlife Diseases

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Burrow Dusting or Oral Vaccination Prevents Plague-Associated Prairie Dog Colony Collapse

et al. 2017

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Plague impacts prairie dogs (Cynomys spp.), the endangered black-footed ferret (Mustela nigripes) and other sensitive wildlife species. We compared efficacy of prophylactic treatments (burrow dusting with deltamethrin or oral vaccination with recombinant “sylvatic plague vaccine” [RCN-F1/V307]) to placebo treatment in black-tailed prairie dog (C. ludovicianus) colonies. Between 2013 and 2015, we measured prairie dog apparent survival, burrow activity and flea abundance on triplicate plots (“blocks”) receiving dust, vaccine or placebo treatment. Epizootic plague affected all three blocks but emerged asynchronously. Dust plots had fewer fleas per burrow (P < 0.0001), and prairie dogs captured on dust plots had fewer fleas (P < 0.0001) than those on vaccine or placebo plots. Burrow activity and prairie dog density declined sharply in placebo plots when epizootic plague emerged. Patterns in corresponding dust and vaccine plots were less consistent and appeared strongly influenced by timing of treatment applications relative to plague emergence. Deltamethrin or oral vaccination enhanced apparent survival within two blocks. Applying insecticide or vaccine prior to epizootic emergence blunted effects of plague on prairie dog survival and abundance, thereby preventing colony collapse. Successful plague mitigation will likely entail strategic combined uses of burrow dusting and oral vaccination within large colonies or colony complexes.Electronic supplementary materialThe online version of this article (doi:10.1007/s10393-017-1236-y) contains supplementary material, which is available to authorized users.

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Vaccines for Conservation: Plague, Prairie Dogs & Black-Footed Ferrets as a Case Study

Salkeld

2017

EcoHealth

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The endangered black-footed ferret (Mustela nigripes) is affected by plague, caused by Yersinia pestis, both directly, as a cause of mortality, and indirectly, because of the impacts of plague on its prairie dog (Cynomys spp.) prey base. Recent developments in vaccines and vaccine delivery have raised the possibility of plague control in prairie dog populations, thereby protecting ferret populations. A large-scale experimental investigation across the western US shows that sylvatic plague vaccine delivered in oral baits can increase prairie dog survival. In northern Colorado, an examination of the efficacy of insecticides to control fleas and plague vaccine shows that timing and method of plague control is important, with different implications for long-term and large-scale management of Y. pestis delivery. In both cases, the studies show that ambitious field-work and cross-sectoral collaboration can provide potential solutions to difficult issues of wildlife management, conservation and disease ecology.

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Using Off-the-Shelf Technologies to Mass Manufacture Oral Vaccine Baits for Wildlife

Cited by 8 publications

References 11 publications

Responses of Juvenile Black-tailed Prairie Dogs (Cynomys ludovicianus) to a Commercially Produced Oral Plague Vaccine Delivered at Two Doses

Responses of Juvenile Black-tailed Prairie Dogs (Cynomys ludovicianus) to a Commercially Produced Oral Plague Vaccine Delivered at Two Doses

Burrow Dusting or Oral Vaccination Prevents Plague-Associated Prairie Dog Colony Collapse

Vaccines for Conservation: Plague, Prairie Dogs & Black-Footed Ferrets as a Case Study

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