The potential of FDG-PET/CT for detecting prostate cancer in patients with an elevated serum PSA level

Minamimoto, Ryogo; Uemura, Hiroji; Sano, Futoshi; Terao, Hideyuki; Nagashima, Yoji; Yamanaka, Shōji; Shizukuishi, Kazuya; Tateishi, Ukihide; Kubota, Yoshinobu; Inoue, Tomio

doi:10.1007/s12149-010-0424-4

Cited by 69 publications

(46 citation statements)

References 26 publications

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“…Consistent with this, an additional study examined resected prostate cancer tissues immunohistochemically using anti-GLUT-1 antibodies, and revealed only weak positive staining. These data also failed to show any correlation between GLUT-1 expression and Gleason score or cancer cell density (Minamimoto et al, 2011).…”

Section: Discussionmentioning

confidence: 73%

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Incidental Abnormal FDG Uptake in the Prostate on 18-fluoro-2-Deoxyglucose Positron Emission Tomography-Computed Tomography Scans

Kang¹,

Seo²,

Lee³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 73%

“…In some reports, 18 F-FDG accumulation is correlated with malignancies rather than benign lesions because the increased FDG uptake is generally linked to elevated cell proliferation (Oyama et al, 1999;Minamimoto et al, 2011). Oyama et al (1999) performed FDG-PET/ CT imaging and assessed the time-activity curve of FDG accumulation (Kc).…”

Section: Resultsmentioning

confidence: 99%

Incidental Abnormal FDG Uptake in the Prostate on 18-fluoro-2-Deoxyglucose Positron Emission Tomography-Computed Tomography Scans

Kang¹,

Seo²,

Lee³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…This further underlines the importance of considering the microenvironment, which potentially modulates intracellular metabolism [152]. Additionally, high grade (Gleason > 7) and castration-resistant tumors seem to reactivate glycolysis, since FDG-PET and FDG-PET/CT studies indicate an increased glucose uptake compared to benign and low stage prostate cancers [153][154][155][156][157]. Accordingly, prostate cancer is affected by 2-deoxyglucose [158][159][160].…”

Section: Later Stage Prostate Cancer Metabolismmentioning

confidence: 97%

Organ-Specific Cancer Metabolism and Its Potential for Therapy

Elia

Schmieder

Christen

et al. 2015

Handbook of Experimental Pharmacology

104

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KEYWORDS:Cancer metabolism, metabolic therapy, tissue specific metabolism, genetic drivers, epigenetic drivers, microenvironment, Warburg effect, reverse Warburg effect, mixed Warburg effect, triple-negative breast cancer, estrogen receptor positive breast cancer; prostate cancer, liver cancer, gluconeogenesis, fatty acid metabolism, glucose metabolism, glutamine metabolism, serine metabolism, metabolic normalization, metabolic depletion ABSTRACTTargeting the metabolism of cancer cells has the potential to lead to major advances in tumor therapy. Numerous promising metabolic drug targets have been identified. Yet, it has emerged that there is no singular metabolism that defines the oncogenic state of the cell. Rather, the metabolism of cancer cells is a function of the requirements of a tumor. Hence, the tissue of origin, the (epi)genetic drivers, aberrant signaling, and the microenvironment all together define these metabolic requirements. In this chapter we discuss in light of (epi)genetic, signaling, and environmental factors the diversity in cancer metabolism based on triple-negative and estrogen receptor positive breast cancer, early and late stage prostate cancer, and liver cancer. These types of cancer all display distinct and partially opposing metabolic behaviors (e.g. Warburg versus reverse Warburg metabolism). Yet, for each of the cancers their distinct metabolism supports the oncogenic phenotype. Finally, we will assess the therapeutic potential of metabolism based on the concepts of metabolic normalization and metabolic depletion.

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“…4,14,15 In one study Minamimoto et al concluded that FDG-PET/CT could potentially detect prostate cancer with 80.0% sensitivity and 87.0% positive predictive value in cases with a Gleason score of 7 or greater. 15 Also, the anatomic location of the incidental uptake should be considered. Prostate lesions occurring in the central zone are less likely to be cancerous, whereas peripheral zone uptake is more often associated with cancer.…”

Section: Discussionmentioning

confidence: 99%

Case: Incidental 18F-fluorodeoxyglucose-positron emission tomography/computed tomography prostate uptake: How should these patients be managed?

Couture

Azizi

Taussky

et al. 2017

CUAJ

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18F-fluorodeoxyglucose-positron emission tomography/ computed tomography (18F-FDG PET/CT) is a widely used diagnostic tool for whole-body imaging, and incidental prostatic uptake occurs in approximately 1% of patients undergoing the exam. Is 18F-FDG PET/CT a reliable screening tool for prostate cancer? Should these patients undergo transrectal ultrasound (TRUS)-guided prostate biopsies? Studies have indicated that 18F-FDG PET/CT has a low positive predictive value for prostate cancer and is not recommended for screening;1 however, other studies suggest that when a discrete focal 18F-FDG uptake is discovered without coincidental calcification, particularly in the peripheral zone of the prostate, further clinical evaluation is recommended. We present two patients with incidental 18F-FDG PET/CT prostatic uptake who were found to have high-grade prostate cancer. Although 18F-FDG PET/CT has not been determined to be a reliable screening tool for prostate cancer, patients with incidental 18F-FDG uptake in the prostate should be referred for urological evaluation.

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The potential of FDG-PET/CT for detecting prostate cancer in patients with an elevated serum PSA level

Abstract: FDG-PET/CT was appropriate for detecting peripheral zone prostate cancer in patients at more than an intermediate risk.

Cited by 69 publications

References 26 publications

Incidental Abnormal FDG Uptake in the Prostate on 18-fluoro-2-Deoxyglucose Positron Emission Tomography-Computed Tomography Scans

Incidental Abnormal FDG Uptake in the Prostate on 18-fluoro-2-Deoxyglucose Positron Emission Tomography-Computed Tomography Scans

Organ-Specific Cancer Metabolism and Its Potential for Therapy

Case: Incidental 18F-fluorodeoxyglucose-positron emission tomography/computed tomography prostate uptake: How should these patients be managed?

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