Incidental Abnormal FDG Uptake in the Prostate on 18-fluoro-2-Deoxyglucose Positron Emission Tomography-Computed Tomography Scans

Kang, Pil Moon; Seo, Won Ik; Lee, Sun Seong; Bae, Soochan; Kwak, Ho Sup; Min, Kweon Sik; Kim, Wansuk; Kang, Dong Il

doi:10.7314/apjcp.2014.15.20.8699

Cited by 23 publications

(13 citation statements)

References 20 publications

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“…Several studies have investigated the clinical significance of 18 F-FDG positive prostate incidentalomas (11,12,13,14,15,16,17). The aim of this study was to determine the frequency of unexpected focal uptake of 18 F-FDG on PET/CT in the prostate glands of cancer patients and to detect the proportion of malignant cases within this group.…”

Section: Introductionmentioning

confidence: 99%

Clinical Significance of 18F-Fluorodeoxyglucose Avid Prostate Gland Incidentalomas on Positron Emission Tomography/Computed Tomography

Makis¹,

Ciarallo

2017

Mirt

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Objective:The aim of this study was to evaluate the clinical significance of incidental focal uptake of 18F-fluorodeoxyglucose (18F-FDG) on positron emission tomography/computed tomography (PET/CT) in the prostate glands of cancer patients.Methods:A retrospective review of 3122 consecutive male patients who underwent 18F-FDG PET/CT studies with an oncologic indication, over the course of four years, was performed. Studies with incidental 18F-FDG uptake in the prostate gland were further analyzed.Results:Incidental 18F-FDG uptake in the prostate gland was identified in 65/3122 men (2.1%). Sufficient follow-up data (≥12 months) were available in 53 patients, of whom 11 had a biopsy and 42 had clinical and imaging follow-up. Malignancy was histologically diagnosed in 4 out of 53 patients (7.5%). There was no statistically significant difference in 18F-FDG uptake values between benign prostate lesions [maximum standardized uptake value (SUVmax) 7.3] and malignant ones (SUVmax 7.2, p=0.95). There was a statistically significant difference between the serum prostate specific antigen (PSA) of the benign group (n=24, PSA=2.7 ng/mL) and the malignant group (n=4, PSA=9.2 ng/mL, p<0.001). There was a direct correlation between SUVmax and Gleason score.Conclusion:18F-FDG positive prostate incidentalomas were detected in 2.1% of oncologic PET/CT scans and of these 7.5% were malignant. SUVmax was not useful for distinguishing between benign and malignant incidental prostate lesions. 18F-FDG avid prostate incidentalomas on PET/CT should prompt a recommendation for obtaining a serum PSA and further investigation if serum PSA is elevated.

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Section: Introductionmentioning

confidence: 99%

Clinical Significance of 18F-Fluorodeoxyglucose Avid Prostate Gland Incidentalomas on Positron Emission Tomography/Computed Tomography

Makis¹,

Ciarallo

2017

Mirt

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“…Many literature reports suggest PIU is not infrequent and is often indicative of malignancy [11][12][13][14][15][16][17][18]. Results on the prevalence of PIU and the incidence of malignancy in studies available in the literature and in this work are summarised in Table 1.…”

Section: Discussionmentioning

confidence: 89%

Multicentre study of 18F-FDG-PET/CT prostate incidental uptake

et al. 2015

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“…The pooled risk of malignancy with biopsy verification was 62% (95% Confidence Interval [CI]: 54–71%). It has been suggested that incidental prostate uptake on FDG PET scans should not be ignored and at least a serum PSA measurement should be considered (13, 14). …”

Section: Detection Of Primary Prostate Tumormentioning

confidence: 99%

Is There Use for FDG-PET in Prostate Cancer?

Jadvar

2016

Seminars in Nuclear Medicine

136

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The utility of positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) in prostate cancer depends on the phase of the disease along the natural history of this prevalent malignancy in men. Incidental high FDG uptake in the prostate gland, while rare, should prompt further investigation with at least a measurement of serum prostate specific antigen (PSA) level. While in general FDG uptake level may significantly overlap among normal, benign, and malignant tissues, aggressive primary tumors with Gleason score greater than 7 tend to display high FDG uptake. PET with FDG may be useful in staging of those patients with aggressive primary tumors and can localize the site of disease in a small fraction of men with biochemical failure and negative conventional imaging studies. FDG PET may be quite useful in treatment response assessment and prognostication of patients with castrate-resistant metastatic prostate cancer.

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Incidental Abnormal FDG Uptake in the Prostate on 18-fluoro-2-Deoxyglucose Positron Emission Tomography-Computed Tomography Scans

Cited by 23 publications

References 20 publications

Clinical Significance of 18F-Fluorodeoxyglucose Avid Prostate Gland Incidentalomas on Positron Emission Tomography/Computed Tomography

Clinical Significance of 18F-Fluorodeoxyglucose Avid Prostate Gland Incidentalomas on Positron Emission Tomography/Computed Tomography

Multicentre study of 18F-FDG-PET/CT prostate incidental uptake

Is There Use for FDG-PET in Prostate Cancer?

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