The Potential of Dewa Leaves (Gynura Pseudochina (L) D.C) and Temu Ireng Rhizomes (Curcuma aeruginosa Roxb.) as Medicinal Herbs for Dengue Fever Treatment

Moektiwardoyo, W. Moelyono; Tjitraresmi, Ami; Susilawati, Yasmiwar; Iskandar, Yoppi; Halimah, Eli; Zahryanti, Dian

doi:10.1016/j.proche.2014.12.017

Cited by 19 publications

(11 citation statements)

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“…, antiinflamasi (Reanmongkol et al, 2006), antimikroba (Jose dan Thomas, 2014;Kamazeri et al, 2012), antiandrogenik (Suphrom et al, 2012), dan berkhasiat dalam meningkatkan kadar trombosit darah (Moektiwardoyo et al, 2014).…”

Section: J Agron Indonesia 44 (3) : 315 -321 (2016)unclassified

“…Berdasarkan variasi hasil ekstrak tersebut menunjukkan bahwa sumber aksesi sangat berpengaruh dalam menentukan jumlah ekstrak yang dihasilkan. Hasil tersebut masih lebih rendah dibandingkan dengan produktivitas ekstrak etanol oleh Moektiwardoyo et al (2014), yang mencapai 24.13%. Perbedaan tersebut lebih dimungkinkan karena lamanya waktu maserasi, yaitu dalam Moektiwardoyo et al (2014) lama waktu maserasi sampai 3 hari, sedangkan dalam penelitian ini hanya 2 hari.…”

Section: Hasil Dan Pembahasanunclassified

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Analisis Kemiripan 20 Aksesi Temu Ireng (Curcuma aeruginosa Roxb.) Berdasarkan Warna Rimpang, Hasil Ekstrak, dan Kandungan Fitokimia

Nurcholis

Khumaida²,

Syukur³

et al. 2017

J Agron Indonesia

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ABSTRACT Curcuma aeruginosa Roxb., popularly known as “temu ireng”, is considered as a potential source of medicinal plant for pharmacological activities. However, varieties of C. aeruginosa are still limited in Indonesia so it needs more accessions for improvement and development of new varieties. Rhizome colors, phytochemical contents and extract yield from 20 promising lines of C. aeruginosa were investigated by qualitative method for rhizome colors and phytochemical contents, and maceration method using 70% ethanol for yield extract. Similarity analysis was used for cluster analysis based on rhizome colors, phytochemical contents and yield extract. Blue was the color characterization of rhizome C. aeruginosa. The extract yield for 20 promising lines of C. aeruginosa varied from 7.92 to 19.71%, with KN and BH promising lines having the lowest and highest value, respectively. All promising lines of C. aeruginosa contain saponin and triterpenoid. Based on similarity analysis, all promising lines could be divided into 3 clusters. Cluster I consisted of 14 promising lines i.e. WG, SH, KA, GD, BH, KP, NW, PW, MB, PR, PT, KN, MD, and PK. Cluster II consisted of 4 promising lines i.e. LC, CB, KL, and GK. Cluster III consisted of 2 promising lines i.e. KD and SG. Keywords: promising lines, saponin, triterpenoid

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Section: J Agron Indonesia 44 (3) : 315 -321 (2016)unclassified

Section: Hasil Dan Pembahasanunclassified

Analisis Kemiripan 20 Aksesi Temu Ireng (Curcuma aeruginosa Roxb.) Berdasarkan Warna Rimpang, Hasil Ekstrak, dan Kandungan Fitokimia

Nurcholis

Khumaida²,

Syukur³

et al. 2017

J Agron Indonesia

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“…In traditional medicine, C. aeruginosa is used to treat many diseases such as flatulence, dysentery, dyspepsia, and gastritis (Theanphong et al 2015). The C. aeruginosa plant contains many biologically active compounds obtained from rhizomes and leaves, used as a possible medicine for various human diseases (Moektiwardoyo et al 2014;Srivilai et al 2018;Suphrom et al 2012). The phytochemical compounds contained in the C. aeruginosa contribute to its pharmacological properties.…”

Section: Introductionmentioning

confidence: 99%

GC-MS analysis of rhizome ethanol extracts from Curcuma aeruginosa accessions and their efficiency activities as anticancer agent

et al. 2021

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Abstract. Nurcholis W, Khumaida N, Bintang M, Syukur M. 2021. GC-MS analysis of rhizome ethanol extracts from Curcuma aeruginosa accessions and their efficiency activities as anticancer agent. Biodiversitas 22: 1179-1186. This work aimed to evaluate the bioactive compounds and anticancer activity in rhizome extract of ten Curcuma aeruginosa accessions to explore their pharmacological values. The GC-MS analysis was used to identify bioactive compounds. The cytotoxic activity was performed against MCF-7 (Human breastadeno carcinoma) and Vero cell lines using MTT assay. The GC-MS analysis revealed 71 of the compounds as sesquiterpenes (36), monoterpenes (20), phenolics (5), diterpenes (4), phenanthrene (1), tetrapeptides (1), oxazole (1), triazine (1), piperidine (1), and oxygenated hydrocarbons (1). The isocurcumenol was the most dominant metabolite in ethanol extract of C. aeruginosa rhizome, with the highest produced by KP accession (22.01%) followed MD accession (21.12%). However, camphor and β-elemene were the metabolites produced by all accessions studied. In the Vero cell line as a normal cell, the cytotoxic activity varied from 13.28% (MD) to 45.17% (PW). Furthermore, the cytotoxic activity ranged from 1.16% (LC) to 49.70% (MD) against the MCF-7 cell line. The highest anticancer activity was produced in MD accessions; thus, it can be used as a source of quality raw materials for the pharmaceutical and food industry. Besides that, it can also be further developed to obtain superior varieties through plant breeding programs.

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“…The C. aeruginosa rhizome is used in folk medicine, including the treatment of rheumatic, asthma, enteritis, stomach pain, obesity, increase appetite, and obesity (Nurcholis et al,016a). Numerous works have reported the biological activity of C. aeruginosa, including its antimicrobial (Kamazeri et al, 2012;Akarchariya et al, 2017), anticancer (Fitria et al, 2019), antioxidant (Nurcholis et al, 016b, 2017), skin lightening, hairgrowth (Srivilai et al, 2017), anti-dengue (Moektiwardoyo et al, 2014), anti-androgenic (Suphrom et al, 2012) and uterine relaxant (Thaina et al, 2009) properties. Previous works have founded the presence of various metabolites such as germacrene, camphor (Akarchariya et al, 2017), curcuminoid (Nurcholis et al, 016a, 2019), cycloisolongifolene, 8,9-dihydro formyl, dihydrocostunolide (Kamazeri et al, 2012), terpenoids (Simoh and Zainal, 2015), and sesquiterpenes (Takano et al, 1995;Suphrom et al, 2012;Awin et al, 2019) in the C. aeruginosa extract.…”

Section: Introductionmentioning

confidence: 99%

Box-Behnken experimental design for extraction optimization of cytotoxic activity from Curcuma aeruginosa rhizome

Khoiriyah

Artika

Nurcholis

2020

ijrps

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Curcuma aeruginosa is the common name of temu hitam in Indonesia, and the rhizome parts of the plant have several pharmacological activities. Generally, pharmacological activities are associated with bioactive content in the extract of medicinal plants. Several factors can in luence the bioactive extraction from medicinal plants such as solvent types, extraction time, extraction technique, and liquid-to-solid ratio. In this research, the extraction factors for extraction yield and cytotoxic activity of C. aeruginosa rhizome were optimized using the Box-Behnken experimental design. Effect of ethanol concentration, the ratio of liquid to solid, and extraction time for the maceration process was studied. The cytotoxic activity was determined by the brine shrimp lethality test. The optimum value that maximizes the extraction yield was 70% ethanol, 300:15 ml/g liquid to solid ratio, and 1-day extraction time. The optimum value that maximizes the cytotoxic activity was 70% ethanol, 150:15 ml/g liquid to solid ratio, and 2-day extraction time. The predicted extraction yield and cytotoxic activity at these projected values are 14.78% and 78.26 mg/l, respectively. In this model, Adeq Precision (10.35 and 4.16), R-Squared (0.86 and 0.79), and F-value (7.92 and 2.04) is rational to it the model for extraction yield and cytotoxic activity from C. aeruginosa rhizome.

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The Potential of Dewa Leaves (Gynura Pseudochina (L) D.C) and Temu Ireng Rhizomes (Curcuma aeruginosa Roxb.) as Medicinal Herbs for Dengue Fever Treatment

Cited by 19 publications

References 1 publication

Analisis Kemiripan 20 Aksesi Temu Ireng (Curcuma aeruginosa Roxb.) Berdasarkan Warna Rimpang, Hasil Ekstrak, dan Kandungan Fitokimia

Analisis Kemiripan 20 Aksesi Temu Ireng (Curcuma aeruginosa Roxb.) Berdasarkan Warna Rimpang, Hasil Ekstrak, dan Kandungan Fitokimia

GC-MS analysis of rhizome ethanol extracts from Curcuma aeruginosa accessions and their efficiency activities as anticancer agent

Box-Behnken experimental design for extraction optimization of cytotoxic activity from Curcuma aeruginosa rhizome

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