The potential of dendrimer in delivery of therapeutics for dentistry

Bapat, Ranjeet; Dharmadhikari, Suyog; Chaubal, Tanay V.; Amin, Mohd Cairul Iqbal Mohd; Bapat, Prachi R.; Gorain, Bapi; Choudhury, Hira; Vincent, Christopher; Kesharwani, Prashant

doi:10.1016/j.heliyon.2019.e02544

Cited by 49 publications

(23 citation statements)

References 107 publications

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“…These nanoparticles are used in the fields of periodontology, restorative dentistry, tissue and bone engineering, dental implants, and cancer diagnosis. Moreover, various shapes of gold nanoparticles have been synthesized by different mechanisms [ 77 ]. As abovementioned, gold nanoparticles play a major role in the rapid and early diagnosis of periodontal disease.…”

Section: Methodsmentioning

confidence: 99%

Biocompatible and Biomaterials Application in Drug Delivery System in Oral Cavity

Hakim

Yazdanian

Alam

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Biomaterials applications have rapidly expanded into different fields of sciences. One of the important fields of using biomaterials is dentistry, which can facilitate implantation, surgery, and treatment of oral diseases such as peri-implantitis, periodontitis, and other dental problems. Drug delivery systems based on biocompatible materials play a vital role in the release of drugs into aim tissues of the oral cavity with minimum side effects. Therefore, scientists have studied various delivery systems to improve the efficacy and acceptability of therapeutic approaches in dental problems and oral diseases. Also, biomaterials could be utilized as carriers in biocompatible drug delivery systems. For instance, natural polymeric substances, such as gelatin, chitosan, calcium phosphate, alginate, and xanthan gum are used to prepare different forms of delivery systems. In addition, some alloys are conducted in drug complexes for the better in transportation. Delivery systems based on biomaterials are provided with different strategies, although individual biomaterial has advantages and disadvantages which have a significant influence on transportation of complex such as solubility in physiological environments or distribution in tissues. Biomaterials have antibacterial and anti-inflammatory effects and prolonged time contact and even enhance antibiotic activities in oral infections. Moreover, these biomaterials are commonly prepared in some forms such as particulate complex, fibers, microspheres, gels, hydrogels, and injectable systems. In this review, we examined the application of biocompatible materials in drug delivery systems of oral and dental diseases or problems.

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Section: Methodsmentioning

confidence: 99%

Biocompatible and Biomaterials Application in Drug Delivery System in Oral Cavity

Hakim

Yazdanian

Alam

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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show abstract

“…Such prepared material showed great potential to be used as a new therapeutic material for the treatment of dentin hypersensitivity. [110,111] PDA Dentine was successfully repaired using polydopamine (PDA), which promoted intrafibrillar mineralization by decreasing the interfacial energy between collagen matrix and ACP. The re-mineralized dentin exhibited comparable mechanical properties to natural dentin.…”

Section: Pamammentioning

confidence: 99%

Biomineralization of Collagen-Based Materials for Hard Tissue Repair

Wei

2021

IJMS

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Hydroxyapatite (HA) reinforced collagen fibrils serve as the basic building blocks of natural bone and dentin. Mineralization of collagen fibrils play an essential role in ensuring the structural and mechanical functionalities of hard tissues such as bone and dentin. Biomineralization of collagen can be divided into intrafibrillar and extrafibrillar mineralization in terms of HA distribution relative to collagen fibrils. Intrafibrillar mineralization is termed when HA minerals are incorporated within the gap zone of collagen fibrils, while extrafibrillar mineralization refers to the minerals that are formed on the surface of collagen fibrils. However, the mechanisms resulting in these two types of mineralization still remain debatable. In this review, the evolution of both classical and non-classical biomineralization theories is summarized. Different intrafibrillar mineralization mechanisms, including polymer induced liquid precursor (PILP), capillary action, electrostatic attraction, size exclusion, Gibbs-Donnan equilibrium, and interfacial energy guided theories, are discussed. Exemplary strategies to induce biomimetic intrafibrillar mineralization using non-collagenous proteins (NCPs), polymer analogs, small molecules, and fluidic shear stress are discussed, and recent applications of mineralized collagen fibers for bone regeneration and dentin repair are included. Finally, conclusions are drawn on these proposed mechanisms, and the future trend of collagen-based materials for bone regeneration and tooth repair is speculated.

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“…The building blocks with its repeating units in the internal layers are arranged in a geometrical fashion, forming concentric layers called generations. 51 Dendrimers are the most extensively explored polymer-based nanocarriers. 52 The polypropylene imine 53 and the polyamidoamine dendrimers 54 are widely studied in the field of medicine.…”

Section: Dendrimersmentioning

confidence: 99%

Nanodrug Delivery Systems in Periodontics

Yadalam

Arumuganainar

Kasipandian

et al. 2021

IJPI

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Nanotechnology is of intense interest to researchers due to the basic fact that the properties of the material can be effectively manipulated when the size is transformed to nanoscopic. New opportunities arise out of the unique features which have been effectually utilized in the development of nano pharmaceuticals. This has revolutionized the health care system extensively by its diverse applications in modern medicine and dental science. Material science and periodontics have jointly adopted this technology to produce nanoparticles for targeted drug delivery, which find considerable significance in the management of periodontal diseases. Periodontitis is principally polymicrobial in nature, affecting the supporting structures of the tooth. In addition to the conventional mechanical debridement, adjunctive chemical therapy is, at most times, required to resolve the chronic inflammation. Hence, targeted drug delivery using nanoparticles with improved pharmacological and therapeutic properties may form better treatment strategies for managing this chronic inflammation. As nanoscale technology finds a scope in varied applications in periodontics, this current review highlights the various nanoscale drug delivery systems for managing periodontal diseases.

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The potential of dendrimer in delivery of therapeutics for dentistry

Cited by 49 publications

References 107 publications

Biocompatible and Biomaterials Application in Drug Delivery System in Oral Cavity

Biocompatible and Biomaterials Application in Drug Delivery System in Oral Cavity

Biomineralization of Collagen-Based Materials for Hard Tissue Repair

Nanodrug Delivery Systems in Periodontics

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