Biomineralization of Collagen-Based Materials for Hard Tissue Repair

Yu, Le; Wei, Mei

doi:10.3390/ijms22020944

Cited by 77 publications

(67 citation statements)

References 121 publications

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“…Hydroxypropylmethylcellulose (HPMC) is a nontoxic polymer that contains a large number of hydroxyl, methyl and methoxy anion groups which share identical sequences with NCPs [ 21 , 22 ]. HPMC has been widely used as a drug carrier in pharmaceutical applications because it can be used as a film-forming material [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Hydroxypropylmethylcellulose as a film and hydrogel carrier for ACP nanoprecursors to deliver biomimetic mineralization

Wang¹,

Zhou²,

Fan³

et al. 2021

J Nanobiotechnol

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Demineralization of hard tooth tissues leads to dental caries, which cause health problems and economic burdens throughout the world. A biomimetic mineralization strategy is expected to reverse early dental caries. Commercially available anti-carious mineralizing products lead to inconclusive clinical results because they cannot continuously replenish the required calcium and phosphate resources. Herein, we prepared a mineralizing film consisting of hydroxypropylmethylcellulose (HPMC) and polyaspartic acid-stabilized amorphous calcium phosphate (PAsp-ACP) nanoparticles. HPMC which contains multiple hydroxyl groups is a film-forming material that can be desiccated to form a dry film. In a moist environment, this film gradually changes into a gel. HPMC was used as the carrier of PAsp-ACP nanoparticles to deliver biomimetic mineralization. Our results indicated that the hydroxyl and methoxyl groups of HPMC could assist the stability of PAsp-ACP nanoparticles and maintain their biomimetic mineralization activity. The results further demonstrated that the bioinspired mineralizing film induced the early mineralization of demineralized dentin after 24 h with increasing mineralization of the whole demineralized dentin (3–4 µm) after 72–96 h. Furthermore, these results were achieved without any cytotoxicity or mucosa irritation. Therefore, this mineralizing film shows promise for use in preventive dentistry due to its efficient mineralization capability. Graphical Abstract

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Section: Introductionmentioning

confidence: 99%

Hydroxypropylmethylcellulose as a film and hydrogel carrier for ACP nanoprecursors to deliver biomimetic mineralization

Wang¹,

Zhou²,

Fan³

et al. 2021

J Nanobiotechnol

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“…The aim of this work was to synthesize a composite using SiO 2 particle as the mineral phase. It must be pointed out, however, that collagen can be combined with a ceramic material using other approaches, such as biomineralization and intrafibrillar silicification of collagen fibrils 32‐34 …”

Section: Discussionmentioning

confidence: 99%

A collagen‐silica‐based biocomposite for potential application in bone tissue engineering

Echazú

Renou

Álvarez

et al. 2021

J Biomedical Materials Res

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Bone is a hierarchical material that has inspired the design of biopolymer‐derived biocomposites for tissue engineering purposes. The present study sought to synthesize and perform the physicochemical characterization and biocompatibility of a collagen‐silica‐based biocomposite for potential application in bone tissue engineering. Ultrastructure, biodegradability, swelling behavior, and biocompatibility properties were analyzed to gain insight into the advantages and limitations to the use of this biomaterial as a bone substitute. Scanning electron microscopy analysis showed a packed‐collagen fibril matrix and silica particles in the biocomposite three‐dimensional structure. As shown by analysis of in vitro swelling behavior and biodegradability, it would seem that the material swelled soon after implantation and then suffered degradation. Biocompatibility properties were analyzed in vivo 14‐days postimplantation using an experimental model in Wistar rats. The biocomposite was placed inside the hematopoietic bone marrow compartment of both tibiae (n = 16). Newly formed woven bone was observed in response to both materials. Unlike the pure‐collagen‐tissue interface, extensive areas of osseointegration were observed at the biocomposite‐tissue interface, which would indicate that silica particles stimulated new bone formation. Agglomerates of finely particulate material with no inflammatory infiltrate or multinucleated giant cells were observed in the bone marrow implanted with the biocomposite. The biocomposite showed good biocompatibility properties. Further studies are necessary to evaluate their biological behavior over time.

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“…In turn, bioactivity is the deposition of calcium phosphate deposits on the surface of materials in the buffer. The buffer contains ions close to human plasma [ 50 , 51 , 52 ]. The most important thing in the pulp capping is the release of calcium ions.…”

Section: Discussionmentioning

confidence: 99%

New Bioactive Calcium Silicate Cement Mineral Trioxide Aggregate Repair High Plasticity (MTA HP)—A Systematic Review

2021

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Bioactive calcium silicate cement Mineral Trioxide Aggregate (MTA) has been used for years as a gold standard in intravital pulp treatment and specialist endodontic procedures. Owing to flaws of the material, the manufacturers have been trying to enhance and produce materials showing improved physical, chemical and biological parameters. One of the new calcium-silicate cements based on mineral trioxide aggregate, however without some flaws exhibited by the cement, is Mineral Trioxide Aggregate Repair High Plasticity (MTA HP). The aim of the present paper was a systematic literature review concerning the MTA HP material used nowadays in dentistry, as a review of its specific features. The present paper is the first article providing a systematic literature review on MTA HP. The aim of the present article is the better understanding of MTA HP properties, which can aid the decision-making process in endodontic treatment.

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Biomineralization of Collagen-Based Materials for Hard Tissue Repair

Cited by 77 publications

References 121 publications

Hydroxypropylmethylcellulose as a film and hydrogel carrier for ACP nanoprecursors to deliver biomimetic mineralization

Hydroxypropylmethylcellulose as a film and hydrogel carrier for ACP nanoprecursors to deliver biomimetic mineralization

A collagen‐silica‐based biocomposite for potential application in bone tissue engineering

New Bioactive Calcium Silicate Cement Mineral Trioxide Aggregate Repair High Plasticity (MTA HP)—A Systematic Review

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