The Potential of Computerized Cognitive Training on HIV-Associated Neurocognitive Disorder: A Case Comparison Study

Hossain, Shyla R.; Fazeli, Pariya L; Tende, Frida; Bradley, Brittany; McKie, Peggy; Vance, David E.

doi:10.1016/j.jana.2017.06.011

Cited by 16 publications

(14 citation statements)

References 13 publications

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“…Indeed, studies have shown that speed of processing may be the most amenable domain to change (Ball et al, 2002), and also may translate to other cognitive domains (Vance et al, 2018). Further, in a similar descriptive case study, Hossain and colleagues (2017) randomized three older adults with HAND to receive either 10 hours of speed-of-processing training, 20 hours of speed-of-processing training, or 10 hours of a sham computer training. The participant who received 20 hours of speed-of-processing no longer met the Frascati criteria for HAND; this is the first and only study to show an intervention that might reverse the HAND diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Individualized-Targeted Computerized Cognitive Training to Treat HIV-Associated Neurocognitive Disorder: An Interim Descriptive Analysis

Vance¹,

Jensen²,

Tende³

et al. 2018

Journal of the Association of Nurses in AIDS Care

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Section: Discussionmentioning

confidence: 99%

Individualized-Targeted Computerized Cognitive Training to Treat HIV-Associated Neurocognitive Disorder: An Interim Descriptive Analysis

Vance¹,

Jensen²,

Tende³

et al. 2018

Journal of the Association of Nurses in AIDS Care

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“…Currently, there is no viable treatment for mild neurocognitive dysfunction in PLWHIV [ 22 , 23 ]. Given the adverse effects associated with long-term use of ART, physical activity interventions may offer a non-pharmacological alternative for managing and rehabilitating HAND in PLWHIV [ 24 ]. Physical activity improves physical functioning, psychological well-being and QoL in the general population as well as amongst PLWHIV [ 25 – 28 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of aerobic exercise on quality of life of people with HIV-associated neurocognitive disorder on antiretroviral therapy: a randomised controlled trial

et al. 2022

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Background HIV-associated neurocognitive disorder (HAND) negatively impacts quality of life (QoL) of people living with HIV who are on antiretroviral therapy (ART). Behavioural intervention adjunct to ART may improve QoL of people with HAND. We determine the effect of a 12-week aerobic exercise programme on QoL in people with HAND who were receiving ART. Trial design This was a parallel-group, randomised controlled trial with concealed allocation and intention-to-treat analysis. Methods We identified 73 participants diagnosed with HAND. Participants were sampled from an earlier study that examined the prevalence of HAND according to the Frascati criteria. Participants were randomised and allocated to an intervention of 12-weeks of aerobic exercise, comprising three 20–60 min sessions per week of moderate-intensity aerobic exercise using a cycle ergometer. The primary outcome was QoL, which was evaluated using the World Health Quality of Life Questionnaire (WHOQoL)-BREF. Results Participants in the exercise (n = 39) and control (n = 35) groups had similar sociodemographic characteristics (p > 0.05). Following the 12-week aerobic exercise programme, participants in the exercise group had improved physical (p < 0.001), psychological (p = 0.008) and environmental (p = 0.001) domains of the QoL (p = 0.001) and overall QoL (p = 0.001) relative to the control group. Similarly, participants in the exercise group had lower depression scores than participants in the control group. Depression scores in the exercise group were still lower 3 months post-intervention (p = 0.007). Only the improvements in physical (p = 0.02) and psychological (p = 0.007) domains of QoL were sustained at 3 months post-intervention. Conclusions Aerobic exercise improves the QoL of people with HAND. To ensure sustained benefits, people with HAND may need to engage in long-term physical exercise. Trial registration The trial is registered with the PAN African Trial Registry (PACTR). Date: 01/09/2020, ID: PACTR202009483415745

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“…Fourth, in a pre/post case comparison study, Hossain et al () randomized three older adults with HAND to receive either 10 hr of speed of processing training, 20 hr of speed of processing training, or 10 hr of a sham internet training in which the participant engaged in normal internet activities on the computer that were not considered to have any therapeutic cognitive benefit. After training, it was observed that the participant who received 20 hr of speed of processing training improved on measures of speed of processing and more importantly, no longer met the cognitive hallmarks of HAND.…”

Section: Introductionmentioning

confidence: 99%

“…Speed of processing training has been shown in the cognitive aging literature to improve not only this cognitive ability but also to benefit other areas, such as better everyday functioning and safer on‐the‐road driving and driving simulator performance, protection against depression, and improved locus of control, self‐rated health, and health‐related quality of life (e.g., Ball & Vance, ; Vance, ; Vance et al, ). As mentioned above, in the case comparison study by Hossain et al (), the participant who received 20 hr of speed of processing training no longer met the cognitive criteria required for a HAND diagnosis. Although the Think Fast study was not designed to investigate if this intervention was effective in reversing HAND, it is encouraging that cognitive training may produce such an effect.…”

Section: Introductionmentioning

confidence: 99%

Can computerized cognitive training reverse the diagnosis of HIV‐associated neurocognitive disorder? A research protocol

Vance

Fazeli

Azuero

et al. 2017

Research in Nursing & Health

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Nearly 50% of adults with HIV have some form of HIV-associated neurocognitive disorder (HAND), ranging from subtle to symptoms that interfere with everyday functioning and quality of life. HAND is diagnosed when a person performs more than 1 standard deviation below his or her normative mean on standardized measures in two or more cognitive domains (e.g., attention, speed of processing, verbal memory, executive functioning). As adults age with HIV, they are more likely to develop comorbidities such as cardiovascular disease, hypertension, and insulin resistance that may further contribute to poorer cognitive functioning and HAND. Certain computerized cognitive training programs may be able to improve specific cognitive domains in those with HIV. Such programs may be effective in changing the diagnosis of HAND in cognitively vulnerable adults. In this article, we describe the design and methods of TOPS-the Training On Purpose Study. In this on-going experimental study, 146 older adults (50+) with HAND are randomized to either: (i) an Individualized-Targeted Cognitive Training group, or (ii) a no-contact control group. This study targets those cognitive domains in which participants experience a deficit and trains participants with the corresponding computerized cognitive training program for that domain. An Individualized Targeted Cognitive Training approach using cognitive-domain-specific cognitive training programs may offer symptom relief to those individuals diagnosed with HAND, which may actually reverse this diagnosis. Given that these cognitive training programs are commercially available, this approach represents a potential paradigm shift in how HAND is considered and treated.

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The Potential of Computerized Cognitive Training on HIV-Associated Neurocognitive Disorder: A Case Comparison Study

Cited by 16 publications

References 13 publications

Individualized-Targeted Computerized Cognitive Training to Treat HIV-Associated Neurocognitive Disorder: An Interim Descriptive Analysis

Individualized-Targeted Computerized Cognitive Training to Treat HIV-Associated Neurocognitive Disorder: An Interim Descriptive Analysis

Effects of aerobic exercise on quality of life of people with HIV-associated neurocognitive disorder on antiretroviral therapy: a randomised controlled trial

Can computerized cognitive training reverse the diagnosis of HIV‐associated neurocognitive disorder? A research protocol

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