The Potential of Aloe vera as an Active Ingredient in Toothpaste Formulations: A Narrative Review

Abstract

Context: Tooth brushing is a primary method to prevent the onset of oral diseases. Aloe vera is commonly used in dentistry as an herbal alternative due to its anti-inflammatory and anti-microbial actions; recently, it has been used in toothpaste formulations as an active agent. This review aimed to investigate the clinical effects of A. vera as an active ingredient in toothpaste formulations. Materials and Methods: The data used in this review was extracted from articles published until 2020. We searched official databases, including Scopus, PubMed, Google Scholar, Embase, and Science Direct, using the “Aloe vera”, “dentifrice”, and “toothpaste” keywords. After screening titles and abstracts, relevant studies were used for full-text review. Results: Although conflicting results have been reported on the usage of A. vera toothpaste in different studies, the majority of findings suggest that A. vera effectively reduces periodontal indices and removes different organisms, including Streptococcus mutans. However, the overall effects of this herbal toothpaste were found to be equal to those of other commercial toothpaste. Conclusions: Aloe vera toothpaste is as beneficial as other kinds of toothpaste. Therefore, it can be used as an adjunct agent in toothpaste due to its established effects on improving periodontal problems and reducing different oral cavity micro-organisms.

Comparative Efficacy of Gingival Massage of Aloe-vera gel and Sidr Honey on Gingival health: a randomized clinical trial

“…However the therapy alone does not restore all the gingival tissues and supplementary aids are used as adjuvant to ultrasonic scaling. [41,42].A bundle of studies have claimed favorable effects of natural products like olive oil, almond oil, green tea, propolis, honey and aloe vera [42][43][44][45][46][47] In this study we observed synergistic effects of gingival massage with two naturopaths that is aloe-vera gel and sidr honey compared with control group.105 participants of gingivitis with 3 loss to follow-up were reported in our research. mean age reported in our study is 48.6 ± 8.6 which is similar to a survey in United States which reported higher prevalence of gingivitis in adults with mean age as > 30 years [48].…”

Evaluation of Aloe vera as a Natural Pharmaceutic in Mouthwashes: A Narrative Review

“…Studies have also demonstrated that the Aloe vera gel's main active components are saponin, aloin, aloemannan, aloeemodin, acemannan, sterols, aloeride, amino acids, and vitamins (11). The pulp of Aloe vera contains 98.5% of water, and the remaining include a range of compounds like vitamins, organic acids, carvacrol, anthraquinones, lignin, and sugar (12). Furthermore, Aloe vera has been used to treat many dental and oral disorders, like oral lichen planus (13), aphthous stomatitis (14), oral submucous fibrosis (15), and bone regeneration (16).…”