Evaluation of Aloe vera as a Natural Pharmaceutic in Mouthwashes: A Narrative Review

Abstract

Context: Mouth rinses have been recognized as the main adjuvant or primary treatment to address many issues relating to dentistry. Previous studies have investigated the anti-inflammatory, anti-arthritic, anti-viral, antioxidant, anti-fungal, and anti-bacterial effects of Aloe vera. Recently, Aloe vera has been applied to treat several dental and oral conditions. Methods: Official web pages, such as Scopus, PubMed, and Microsoft were searched for collecting the required data using the keywords Aloe vera, Aloe vera mouthwash, Aloe vera mouth rinse, and dentistry. After checking the abstracts and titles, all relevant papers were retrieved for performing a full-text review. Results: Aloe vera was effective in reducing periodontal indices compared to chlorhexidine. It was also effective in treating oral diseases such as mucositis, postoperative pain, trismus, and dry socket incidence after the third molar extraction. Aloe vera decreased the number of colony-forming units during scaling and root planning (SRP). Conclusions: Aloe vera mouthwash was just as effective as other commercial mouthwashes in reducing the severity of radiation-induced mucositis, periodontal disease, the amount of S. mutans, the number of colony-forming units during SRP, and other situations which required a mouth rinse for the acceleration of treatment.

Antioxidant Effect of Mouthwash Containing Zinc, Aloe Vera, and Stabilized Chlorine Dioxide for Oral Manifestation of Acute Myeloblastic Leukemia (Aml)

“…Aloe barbadensis miller is a botanical name of Aloe vera [27]. Aloe vera belongs to the Liliaceae family with mucilaginous tissue in its leaf's center [28]. The Aloe vera plant has anti-fungal, anti-inflammatory, antioxidant, immune-modulating, and anti-bacterial properties [17,28].…”

“…Aloe vera belongs to the Liliaceae family with mucilaginous tissue in its leaf's center [28]. The Aloe vera plant has anti-fungal, anti-inflammatory, antioxidant, immune-modulating, and anti-bacterial properties [17,28]. Studies have reported the anti-inflammatory effect of Aloe vera, where the gel exerts its anti-inflammatory property through inhibition of COX2, prostaglandins, bradykinins, TNF-α, IL-1β, and extracellular signal-regulated kinase pathway [28].…”

Patent Mining on the Use of Antioxidant Phytochemicals in the Technological Development for the Prevention and Treatment of Periodontitis

“…Alternatively, the patent literature has described the antioxidant, anti-gingivitis, and anti-inflammatory activities of medicinal plant extracts used to develop technologies for treating periodontal disease. Among the medicinal plants mentioned, the following stand out: Zingiber ginger and Alpine officinarum [112], Pepper nigrum, Olea europae [113], Lycium barbarum [114], red tea [115], Acacia nilotica (L.) Delile [116], Aegiceras corniculatum [117], Calendula officinalis [118], tea tree oil and Aloe vera [119], Triphala, Ayurvedic medicinal herbal formulations [120], Ficus deltoidea [121], Arctium lappa, Zataria multiflora and Echinacea purpurea [122], Pistacia lentiscus L. [123], Curcuma longa [124], Nigella sativa [125], and Chrysopogon zizanioides [126].…”

Assessing the effectiveness of a herbal mouthwash against oral pathogens: analysis

“…In adddition to mouthwash type, this study also looked at mouthwash quantity to be used. 8 To develop a herbal mouthwash employing the herbs Azadirachta indica, Ocimum tenuiflorum and Clinacanthus nutans that would be more effective and environmentally friendly. Mechanical plaque control is less technically complex than chemical plaque reduction techniques, such as mouthwashes.…”