The Potential Influence of Plant Polyphenols on the Aging Process

Cherniack, E. Paul

doi:10.1159/000319143

Cited by 19 publications

(8 citation statements)

References 82 publications

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“…Many plant polyphenols also share an ability to down‐regulate PI3K/Akt, activate AMPK and sirtuins, and suppress NF‐κB signaling . These redox‐regulated pathways have also been implicated as underlying mechanisms for the health‐promoting and lifespan‐increasing effects of dietary polyphenols …”

Section: Free Radical Scavenging and Redox Modulation Of Enzymes And mentioning

confidence: 99%

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The mechanism(s) of action of antioxidants: From scavenging reactive oxygen/nitrogen species to redox signaling and the generation of bioactive secondary metabolites

Hunyadi

2019

Medicinal Research Reviews

131

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Small molecule, dietary antioxidants exert a remarkably broad range of bioactivities, and many of these can be explained by the influence of antioxidants on the redox homeostasis. Such compounds help to modulate the levels of harmful reactive oxygen/nitrogen species, and therefore participate in the regulation of various redox signaling pathways. However, upon ingestion, antioxidants usually undergo extensive metabolism that can generate a wide range of bioactive metabolites. This makes it difficult, but otherwise a need, to identify the ones responsible for the different activities of antioxidants. By better understanding their ways of action, the use of antioxidants in therapy can be improved. This review provides a summary on the role of the in vivo metabolic changes and the oxidized metabolites on the mechanisms behind the bioactivity of antioxidants. A special attention is given to metabolites described as products of biomimetic oxidative chemical reactions, which can be considered as models of free radical scavenging. During such reactions a wide variety of metabolites are formed, and they can exert completely different specific bioactivities as compared to their parent antioxidants. This implies that exploring the free radical scavenging‐related metabolite fingerprint of each antioxidant molecule, collectively defined here as the scavengome, will lead to a deeper understanding of the bioactivity of these compounds. Furthermore, this paper aims to be a working tool for systematic studies on oxidized metabolic fingerprints of antioxidants, which will certainly reveal an often‐neglected segment of chemical space that is a treasury of bioactive compounds.

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Section: Free Radical Scavenging and Redox Modulation Of Enzymes And mentioning

confidence: 99%

“…47 These redox-regulated pathways have also been implicated as underlying mechanisms for the health-promoting and lifespan-increasing effects of dietary polyphenols. 48…”

mentioning

confidence: 99%

The mechanism(s) of action of antioxidants: From scavenging reactive oxygen/nitrogen species to redox signaling and the generation of bioactive secondary metabolites

Hunyadi

2019

Medicinal Research Reviews

131

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“…The common understanding of food has evolved from the previous concept "eat to live" to health promotion and disease prevention. Substantial dietary intervention studies and epidemiological surveys have demonstrated that the consumption of a diet rich in fruits and vegetables has health-promoting effects [1,2]. It is estimated that the proportion of people aged 60 and above will increase from 12% in 2015 to 22% in 2050 [3].…”

Section: Introductionmentioning

confidence: 99%

Dietary Anti-Aging Polyphenols and Potential Mechanisms

Luo

Jia

et al. 2021

Antioxidants

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For years, the consumption of a diet rich in fruits and vegetables has been considered healthy, increasing longevity, and decreasing morbidities. With the assistance of basic research investigating the potential mechanisms, it has become clear that the beneficial effects of plant-based foods are mainly due to the large amount of bioactive phenolic compounds contained. Indeed, substantial dietary intervention studies in humans have supported that the supplementation of polyphenols have various health-promoting effects, especially in the elderly population. In vitro examinations on the anti-aging mechanisms of polyphenols have been widely performed, using different types of natural and synthetic phenolic compounds. The aim of this review is to critically evaluate the experimental evidence demonstrating the beneficial effects of polyphenols on aging-related diseases. We highlight the potential anti-aging mechanisms of polyphenols, including antioxidant signaling, preventing cellular senescence, targeting microRNA, influencing NO bioavailability, and promoting mitochondrial function. While the trends on utilizing polyphenols in preventing aging-related disorders are getting growing attention, we suggest the exploration of the beneficial effects of the combination of multiple polyphenols or polyphenol-rich foods, as this would be more physiologically relevant to daily life.

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“…In addition, other nutrients and bioactive polyphenols such as resveratrol (RES), curcumin (CUR) and quercetin also have a substantial impact on the aging process in different organisms [ 20 ]. Figure 1 illustrates numerous aging-related diseases such as cancer [ 21 ], neurodegenerative diseases [ 22 ], nephrosclerosis, arthritis and cardiovascular diseases [ 23 ] caused by a number of genetic and non-genetic factors.…”

Section: Introductionmentioning

confidence: 99%

The Epigenetic Link between Polyphenols, Aging and Age-Related Diseases

Arora

Sharma

Sun

et al. 2020

Genes

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Aging is a complex process mainly categorized by a decline in tissue, cells and organ function and an increased risk of mortality. Recent studies have provided evidence that suggests a strong association between epigenetic mechanisms throughout an organism’s lifespan and age-related disease progression. Epigenetics is considered an evolving field and regulates the genetic code at several levels. Among these are DNA changes, which include modifications to DNA methylation state, histone changes, which include modifications of methylation, acetylation, ubiquitination and phosphorylation of histones, and non-coding RNA changes. As a result, these epigenetic modifications are vital targets for potential therapeutic interventions against age-related deterioration and disease progression. Dietary polyphenols play a key role in modulating these modifications thereby delaying aging and extending longevity. In this review, we summarize recent advancements linking epigenetics, polyphenols and aging as well as critical findings related to the various dietary polyphenols in different fruits and vegetables. In addition, we cover studies that relate polyphenols and their epigenetic effects to various aging-related diseases such as cardiovascular diseases, neurodegenerative diseases, autoimmune disorders, diabetes, osteoporosis and cancer.

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The Potential Influence of Plant Polyphenols on the Aging Process

Cited by 19 publications

References 82 publications

The mechanism(s) of action of antioxidants: From scavenging reactive oxygen/nitrogen species to redox signaling and the generation of bioactive secondary metabolites

The mechanism(s) of action of antioxidants: From scavenging reactive oxygen/nitrogen species to redox signaling and the generation of bioactive secondary metabolites

Dietary Anti-Aging Polyphenols and Potential Mechanisms

The Epigenetic Link between Polyphenols, Aging and Age-Related Diseases

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