Dietary Anti-Aging Polyphenols and Potential Mechanisms

Luo, Jing; Si, Hongwei; Jia, Zhenquan; Liu, Dongmin

doi:10.3390/antiox10020283

Cited by 84 publications

(54 citation statements)

References 191 publications

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“…Sweet cherries are fruit with high content of phenolic compounds, mainly anthocyanins, which are primarily responsible for the beneficial health effects attributed to cherry consumption [6,[33][34][35]. In fact, phenolic compounds and especially anthocyanins have strong antioxidant activity and preventive effects on a wide range of age-related and chronic diseases, such as neurodegenerative, cardiovascular and oncologic diseases, hypertension, obesity and diabetes, among others [36][37][38]. The results of the present research show enhanced levels of phenolic and total and individual anthocyanin concentrations in fruit from melatonin-treated trees in the three sweet cherry cultivars tested.…”

Section: Discussionmentioning

confidence: 99%

Effects of Melatonin Treatment on Sweet Cherry Tree Yield and Fruit Quality

et al. 2021

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The effects of preharvest melatonin treatment, applied as foliar spray at 0.1, 0.3 and 0.5 mM concentration at three key points of fruit development (pit hardening, initial colour changes and 3 days before harvesting), on crop yield and fruit quality properties at harvest was evaluated in three sweet cherry cultivars, ‘Prime Giant’, ‘Lapins’ and ‘Sweet Heart’, and two years, 2019 and 2020. The results showed that melatonin treatment had no effect on crop yield, except for the ‘Lapins’ cultivar, in which increases were found. However, decayed and cracked fruit percentage was decreased in all cultivars in 2020 when adverse weather conditions occurred and commercial crop yield was increased, especially for 0.3 mM dose. Fruit quality traits at harvest, such as fruit weight, colour, firmness, total soluble solids and titratable acidity, were enhanced by melatonin treatments in all sweet cherry cultivars and in both years. Moreover, bioactive compounds, such as total phenolics and total and individual anthocyanins, were also found at higher levels in fruit from melatonin-treated trees with respect to controls. Thus, taking into account all these effects, 0.3 mM melatonin foliar spray, at three key points of fruit developmental stages, could be a useful tool to improve crop yield and quality traits of sweet cherries, especially their content on bioactive compounds with antioxidant properties and health beneficial effects.

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Section: Discussionmentioning

confidence: 99%

Effects of Melatonin Treatment on Sweet Cherry Tree Yield and Fruit Quality

et al. 2021

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“…Results of the present experiments show that preharvest melatonin treatments enhanced total phenolic compound and total and individual anthocyanin concentrations at harvest, leading to increases in H-TAA, with these effects being maintained during storage. Thus, preharvest melatonin treatments would improve the pomegranate health beneficial effects for human consumption since phenolic compounds, including anthocyanins, are a wide range of secondary metabolites with preventive effects on a wide range of chronic and age-related diseases, such as hypertension, obesity, diabetes, cardiovascular, neurodegenerative and oncologic diseases [ 9 , 37 , 38 , 39 ]. No previous reports are available in the literature regarding the effect of melatonin treatment on pomegranate bioactive compounds, and little information exists on other fruit species.…”

Section: Discussionmentioning

confidence: 99%

Melatonin Treatment to Pomegranate Trees Enhances Fruit Bioactive Compounds and Quality Traits at Harvest and during Postharvest Storage

et al. 2021

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The effect of melatonin pomegranate tree treatments on fruit quality and bioactive compounds with antioxidant activity at harvest and during storage at 10 °C for 60 days was assayed in two consecutive years, 2019 and 2020. In the first year, trees were treated with 0.1, 0.3 and 0.5 mM of melatonin along the developmental fruit growth cycle, and results showed that bioactive compounds (total phenolics and total and individual anthocyanins) and antioxidant activity at harvest were higher in fruits from melatonin-treated trees than in controls. Other fruit quality parameters, such as firmness, total soluble solids and aril red colour, were also increased as a consequence of melatonin treatment. In fruit from control tress, firmness and acidity levels decreased during storage, while increases occurred on total soluble solids, leading to fruit quality reductions. These changes were delayed, and even maintenance of total acidity was observed, in fruit from melatonin-treated trees with respect to controls, resulting in a fruit shelf-life increase. Moreover, concentration of phenolics and anthocyanins and antioxidant activity were maintained at higher levels in treated than in control fruits during the whole storage period. In general, all the mentioned effects were found at the highest level with the 0.1 mM melatonin dose, and then it was selected for repeating the experiment in the second year and results of the first year were confirmed. Thus, 0.1 mM melatonin treatment could be a useful tool to enhance aril content on bioactive compounds with antioxidant activity and health beneficial effects and to improve quality traits of pomegranate fruit, at harvest and during postharvest storage.

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“…The anti-aging properties of dietary polyphenols have been ascribed at least in part to their antioxidant properties that, through several mechanisms including ROS-scavenging actions, contribute to reduce oxidative stress. These mechanisms play an important role in the aging process and various aging-associated chronic diseases [ 48 ], including bone mineral density, by preventing oxidation-induced damage to bone cells [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

Dietary Polyphenol Intake Is Associated with Biological Aging, a Novel Predictor of Cardiovascular Disease: Cross-Sectional Findings from the Moli-Sani Study

et al. 2021

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Biological aging, or the discrepancy between biological and chronological age of a subject (Δage), has been associated with a polyphenol-rich Mediterranean diet and represents a new, robust indicator of cardiovascular disease risk. We aimed to disentangle the relationship of dietary polyphenols and total antioxidant capacity with Δage in a cohort of Italians. A cross-sectional analysis was performed on a sub-cohort of 4592 subjects (aged ≥ 35 y; 51.8% women) from the Moli-sani Study (2005–2010). Food intake was recorded by a 188-item food-frequency questionnaire. The polyphenol antioxidant content (PAC)-score was constructed to assess the total dietary content of polyphenols. Total antioxidant capacity was measured in foods by these assays: trolox equivalent antioxidant capacity (TEAC), total radical-trapping antioxidant parameter (TRAP) and ferric reducing-antioxidant power (FRAP). A deep neural network, based on 36 circulating biomarkers, was used to compute biological age and the resulting Δage, which was tested as outcome in multivariable-adjusted linear regressions. Δage was inversely associated with the PAC-score (β = −0.31; 95%CI −0.39, −0.24) but not with total antioxidant capacity of the diet. A diet rich in polyphenols, by positively contributing to deceleration of the biological aging process, may exert beneficial effects on the long-term risk of cardiovascular disease and possibly of bone health.

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Dietary Anti-Aging Polyphenols and Potential Mechanisms

Cited by 84 publications

References 191 publications

Effects of Melatonin Treatment on Sweet Cherry Tree Yield and Fruit Quality

Effects of Melatonin Treatment on Sweet Cherry Tree Yield and Fruit Quality

Melatonin Treatment to Pomegranate Trees Enhances Fruit Bioactive Compounds and Quality Traits at Harvest and during Postharvest Storage

Dietary Polyphenol Intake Is Associated with Biological Aging, a Novel Predictor of Cardiovascular Disease: Cross-Sectional Findings from the Moli-Sani Study

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