The Potential Implication of FTO rs17817449 Gene Polymorphism on BMI Mediated Risk For Type2 Diabetes Among Obese Egyptian Children And Adolescents

Abstract

Background: Genetic variations of the FTO gene were associated with obesity and type 2 diabetes determinants in the European population, notably raised blood levels of insulin and glucose. Objective: The aim of this study was to test the association of FTOrs17817449 with obesity/BMI and type 2 diabetes risk among obese Egyptian population. Materials and Methods: In this case-control study, (PCR-RFLP assay) was used for genotyping FTOrs17817449polymorphism (SNP) in 120 obese children and 120 controls conducted from attendants of genetic & endocrinology Unit and outpatient clinics, Pediatric Department, Faculty of Medicine, Menoufia University Hospitals. In combination with anthropometric measurements of obesity, predisposition to T2D risk was analyzed (fasting insulin, fasting glucose, insulin resistance). Results: Consanguinity was evident in 32.5% of cases. Positive family history of both obesity and T2D was found to be significant statistically (p<0.05). FTO rs17817449G allele was positively associated with WC (Waist Circumference) (Mean ± SD 84.1 ± 9. 3), raised BMI (Body Mass Index) (32.7 ± 3.5), fasting glucose (114.1 ± 12.8mg/dl), fasting insulin (7.2 ± 1.2µU/ml) and insulin resistance (61.1% of cases) (p<0.001). : The odds ratio of obesity was 1.75(95%CI 1.02-3.02) for GT and GG genotype. Fasting glucose and fasting insulin showed statistically significant risk for T2D in the obese group. Conclusion: Genetic variation in FTOrs17817449(G allele) was definitely associated with raised BMI, BMI z-score and fasting insulin, and lowered QUICKI values, that predicted the risk for type 2 diabetes among obese children harboring the mutant G allele.

Association betweenFTO(rs17817449) genetic variant, gamma‐glutamyl transferase, and hypertension in Slovak midlife women

“…Surprisingly, some FTO associations had lower GGT values, thus indicating a protective role in liver enzyme concentrations. These included GG homozygosity which is a risk factor for obesity (Barseem et al, 2019;Hinney et al, 2007;Jawad & Rasool, 2019;Scuteri et al, 2007) and T2DM development (Hubacek et al, 2018. We are also aware of only one study which associated risk with the T allele. Therein, Algenabi et al (2020) revealed that the FTO rs17817449 T allele negatively affects the markers of glycemic control and dyslipidemia in an Iraqi population.…”

Methylation and Expression of FTO and PLAG1 Genes in Childhood Obesity: Insight into Anthropometric Parameters and Glucose–Lipid Metabolism

“…Although the impact of environmental factors, like a sedentary lifestyle and excessive nutrient supply, has a large contribution to the end result, more attention should be paid to other relevant obesity-related factors [ 4 ]. Many studies, also in the pediatric population, focus on single nucleotide polymorphisms (SNPs) in genes with a well-described relationship with obesity, such as FTO [ 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ], or genes, whose role in obesity is recently gradually being discovered, as the PLAG1 gene [ 16 , 17 , 18 ]. However, very few studies address the impact of epigenetics, including the DNA methylation of CpG dinucleotides, on this phenomenon [ 19 , 20 ].…”

Influence of the FTO polymorphism rs17817449 on the risk of obesity, type 2 diabetes, and cardiovascular diseases in Upper Silesian population — a preliminary, cross-sectional study

“…Some research revealed association between FTO rs17817449 and parameters related to metabolic syndrome and type 2 diabetes such as BMI, fasting glucose, fasting insulin, and insulin resistance thus directly increasing the risk of type 2 diabetes development. Such observations were reported in popula-tions of Egypt, the UK, France, Canada, and European Americans [18,19]. In the Czech population the GG genotype of FTO variant rs17817449 was significantly more frequent in individuals with type 2 diabetes.…”