Constitutive neurogenesis affects both children and adults and is known to correlate closely with neurocognitive functions such as learning and memory [1]. Infl ammation is a systemic reaction. However, the brain reacts to infl ammation differently than peripheral tissues. Under normal conditions, the Blood-Brain Barrier (BBB) is selectively permeable and allows only the passage of T-cells, macrophages, and dendritic cells [2]. However, infl ammation of the brain initiates the secretion of anti-and pro-infl ammatory cytokines by resident microglia, astrocytes, infi ltrating peripheral macrophages, and lymphocytes. This activity both stimulates the migration of leukocytes to the region and promotes astrogliosis [3]. Pathologically, Parkinson's Disease (PD) is characterized by the massive degeneration and loss of nigrostriatal dopaminergic neurons. Many studies of PD have also emphasized the