Pro-inflammatory cytokine and vascular adhesion molecule levels in manganese and lead-exposed workers

Öztan, Özgür; Türksoy, Vugar Ali; Daltaban, İskender Samet; Gündüzöz, Meşide; Tutkun, Lütfiye; İritaş, Servet Birgin; Ak, Hakan

doi:10.17352/2455-8591.000020

Cited by 7 publications

(5 citation statements)

References 45 publications

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“…On the other hand, VCAM-1 adhesion molecule is known to induce tumor cells (21). The changes in the biomarker levels we used in our study are compatible with the studies in the literature (8,10,15) and it is one of the rare studies conducted among workers exposed to nickel. The results obtained allow these biomarkers to be used to detect both inflammation and cancer risk in annual periodic followups of workers exposed to nickel.…”

Section: Discussionsupporting

confidence: 89%

“…The advances achieved with biological-analytical techniques in the field of biomarkers accelerate the studies on the effectiveness of exposure to chemical agents, individual or population susceptibility, risk assessments, the dose-response relationship for chemicals and treatments (6). Tumor Necrosis Factor (TNF-α) is one of the pro-inflammatory cytokines mediating immune regulation (7,8). TNF-alpha has also been suggested to be an endogenous tumor promoter (9).…”

Section: Introductionmentioning

confidence: 99%

“…Like TNF-α, Interleukin (IL)-6 plays an important pathophysiological role not only in inflammatory diseases but also in cancers. However, Vascular Cell Adhesion protein (VCAM-1), TNF-α, IL-10 and IL-6 especially play an important role in the interpretation of systemic inflammatory responses (7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

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Investigation of the potential use of VCAM-1, TNF-α, IL-10 and IL-6 as biomarkers of nickel exposure

Öztan¹,

Türksoy

Deniz

et al. 2021

Anatolian Current Medical Journal

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Objectives: Industrial and agricultural activities such as mining, smelting, and the discharging of industrial and domestic wastewater have increased the severity of heavy metal pollution in environments. Nickel poisoning continues to be an important occupational health problem in many branches of industry, especially coating. Occupational exposure to nickel can occur through skin contact or inhalation of nickel-containing aerosols, dust, or fumes. As a result of the toxic effect of nickel, it can cause various health problems, including respiratory and dermatological effects. Material and Method:The study included 56 male workers exposed to nickel in a coating factory (Ni-exposed group) and 44 non-exposed male workers (control group). Vascular Cell Adhesion protein (VCAM)-1, Tumor Necrosis Factor (TNF)-α, Interleukin (IL)-10, and IL-6 levels of serum were analyzed using enzyme-linked immunosorbent assays (ELISA). Ni levels were determined using inductively coupled plasma mass spectrometry (ICP-MS) in urine samples. Results: Significant intergroup differences were observed in the levels of all inflammatory parameters such as VCAM-1, TNF-α, IL-10 and IL-6 (p<0.01 for all). Conclusions: The correlations between increased inflammatory biomarkers levels and exposed/control groups suggest a close relationship between inflammation and toxicity. This relationship provides a clinical model for the early diagnosis of nickel toxicity.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

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Investigation of the potential use of VCAM-1, TNF-α, IL-10 and IL-6 as biomarkers of nickel exposure

Öztan¹,

Türksoy

Deniz

et al. 2021

Anatolian Current Medical Journal

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“…KYNA inhibits TNF-α at a transcriptional level [86]. An elevated brain TNF-α level plays a pivotal role in the pathogenesis of neurodegenerative disorders [87]. KYNA inhibition of TNF-α production may consequently be a significant factor in neuroprotection.…”

Section: Kynurenine Aminotransferasesmentioning

confidence: 99%

Immune Influencers in Action: Metabolites and Enzymes of the Tryptophan-Kynurenine Metabolic Pathway

et al. 2021

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The tryptophan (TRP)-kynurenine (KYN) metabolic pathway is a main player of TRP metabolism through which more than 95% of TRP is catabolized. The pathway is activated by acute and chronic immune responses leading to a wide range of illnesses including cancer, immune diseases, neurodegenerative diseases and psychiatric disorders. The presence of positive feedback loops facilitates amplifying the immune responses vice versa. The TRP-KYN pathway synthesizes multifarious metabolites including oxidants, antioxidants, neurotoxins, neuroprotectants and immunomodulators. The immunomodulators are known to facilitate the immune system towards a tolerogenic state, resulting in chronic low-grade inflammation (LGI) that is commonly present in obesity, poor nutrition, exposer to chemicals or allergens, prodromal stage of various illnesses and chronic diseases. KYN, kynurenic acid, xanthurenic acid and cinnabarinic acid are aryl hydrocarbon receptor ligands that serve as immunomodulators. Furthermore, TRP-KYN pathway enzymes are known to be activated by the stress hormone cortisol and inflammatory cytokines, and genotypic variants were observed to contribute to inflammation and thus various diseases. The tryptophan 2,3-dioxygenase, the indoleamine 2,3-dioxygenases and the kynurenine-3-monooxygenase are main enzymes in the pathway. This review article discusses the TRP-KYN pathway with special emphasis on its interaction with the immune system and the tolerogenic shift towards chronic LGI and overviews the major symptoms, pro- and anti-inflammatory cytokines and toxic and protective KYNs to explore the linkage between chronic LGI, KYNs, and major psychiatric disorders, including depressive disorder, bipolar disorder, substance use disorder, post-traumatic stress disorder, schizophrenia and autism spectrum disorder.

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“…KYNA inhibits TNF-α a at a transcriptional level [86]. An elevated brain TNF-α level plays a pivotal role in the pathogenesis of neurodegenerative disorders [87]. KYNA inhibition of TNF-α production may consequently be a significant factor in neuroprotection.…”

Section: Kynurenine Aminotransferasesmentioning

confidence: 99%

Immune Influencers in Action: Metabolites and Enzymes of the Tryptophan-Kynurenine Metabolic Pathway

Tanaka¹,

Tóth²,

Polyák³

et al. 2021

Preprint

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The tryptophan (TRP)-kynurenine (KYN) metabolic pathway is a main player of TRP metabolism through which more than 95% of TRP is catabolized. The pathway is activated by acute and chronic immune responses leading to a wide range of illnesses including cancer, immune diseases, neurodegenerative diseases, and psychiatric disorders. The TRP-KYN pathway synthesizes multifarious metabolites including oxidants, antioxidants, neurotoxins, neuroprotectants, and immunomodulators. The immunomodulators are known to facilitate the immune system towards a tolerogenic state, resulting in chronic low-grade inflammation (LGI) that is commonly present in obesity, poor nutrition, exposer to chemicals or allergens, prodromal stage of various illnesses, and chronic diseases. KYN, kynurenic acid, xanthurenic acid, and cinnabarinic acid are aryl hydrocarbon receptor ligands that serve as immunomodulators. Furthermore, TRP-KYN pathway enzymes are known to be activated by the stress hormone cortisol and inflammatory cytokines, and genotypic variants were observed to contribute to inflammation and thus various diseases. The tryptophan 2,3-dioxygenase, the indoleamine 2, 3-oxygenases, and the kynurenine-3-monooxygenase are main enzymes in the pathway. This review article discusses the TRP-KYN pathway with special emphasis on its interaction with the immune system and the tolerogenic shift towards chronic LGI and overviews the major symptoms, pro- and anti-inflammatory cytokines, and toxic and protective KYNs to explore the linkage between chronic LGI, KYNs, and major psychiatric, including depressive disorder, bipolar disorder, substance use disorder, post-traumatic stress disorder, schizophrenia, and autism spectrum disorder.

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Pro-inflammatory cytokine and vascular adhesion molecule levels in manganese and lead-exposed workers

Cited by 7 publications

References 45 publications

Investigation of the potential use of VCAM-1, TNF-α, IL-10 and IL-6 as biomarkers of nickel exposure

Investigation of the potential use of VCAM-1, TNF-α, IL-10 and IL-6 as biomarkers of nickel exposure

Immune Influencers in Action: Metabolites and Enzymes of the Tryptophan-Kynurenine Metabolic Pathway

Immune Influencers in Action: Metabolites and Enzymes of the Tryptophan-Kynurenine Metabolic Pathway

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