Abstract. In this research, the feasibility of solar assisted desiccant evaporative cooling system for o ce buildings was studied. An o ce building located in Chabahar, Iran, as a high cooling load demanding region, was considered as the case study. Di erent con gurations as desiccant-based cooling systems were examined to determine the most appropriate con guration in terms of established indoor air conditions and required cooling energy. The con gurations were simulated hourly, and the monthly mean values were determined. TRNSYS software was used for this purpose. The results indicated that the desiccant-based cooling system operating in the recirculation cycle with precooling Con g. E has the potential to keep the indoor air conditions within the standard recommendations. In addition, it was shown that Con g. E is the superior con guration in terms of the energy performance and can meet the cooling energy requirements of the space. The potential for providing the desiccant regeneration heat by the solar energy was also investigated. Three standard solar thermal panels were explored to propose the most proper array plant. The study showed that an array of solar panels, consisting of two rows of four unglazed solar thermal collectors, could meet the heat energy requirement by the regenerating process.