The Potential for Plant Derivatives against Acrylamide Neurotoxicity

Abstract

Certain industrial chemicals and food contaminants have been demonstrated to possess neurotoxic activity and have been suspected to cause brain-related disorders in humans. Acrylamide (ACR), a confirmed neurotoxicant, can be found in trace amount in commonly consumed human aliments as a result of food processing or cooking. This discovery aroused a great concern in the public, and increasing efforts are continuously geared towards the resolution of this serious threat. The broad chemical diversity of plants may offer the resources for novel antidotes against neurotoxicants. With the goal of attenuating neurotoxicity of ACR, several plants extracts or derivatives have been employed. This review presents the plants and their derivatives that have been shown most active against ACR-induced neurotoxicity, with a focus on their origin, pharmacological activity, and antidote effects.

The anti-apoptotic, antioxidant and anti-inflammatory effects of curcumin on acrylamide-induced neurotoxicity in rats

“…In the present study, we demonstrated the anti-apoptotic, antioxidant and anti-in ammatory effects of curcumin on ACR-induced neurotoxicity in rats, suggesting the use of curcumin to prevent or delay neurological damages induced by ACR exposure. In line with the evidences from humans and animals [4,5,8,[11][12][13][14], our study showed that the 4-week exposure of rats to ACR at the dose of 40 mg/kg caused a signi cant body weight loss, progressive de cits in motor function and adverse pathological outcome in the cortex and hippocampus of rats. Importantly, the present data revealed that curcumin administration could e ciently rescue ACRinduced weight loss and neurobehavioral de cits, relieve the neuropathological damages in brain.…”

“…Accordingly, in recent years, some agents with anti-apoptosis, antioxidant and anti-in ammatory properties have been expected to attenuate ACR-induced neurotoxicity [3,8,[11][12][13][14]. As the most active constituent in turmeric, a common spice, with a strong safety record, curcumin has been considered to be a potential natural neuroprotective agent under limelight [15][16][17][18].…”

Evaluation of acrylamide-removing properties of two Lactobacillus strains under simulated gastrointestinal conditions using a dynamic system

“…Acrylamide (AA) has received great attention in recent years because it has proven to produce neurotoxic effects in animals and humans, reproductive and genotoxic outcomes in rodents, and mutagenicity in somatic cells in vitro and in vivo (Adewale et al, 2015;Kim et al, 2015). Additionally, AA was classified by the International Agency for Research on Cancer (IARC) as probably carcinogenic to humans (Oracz et al, 2011).…”

Evaluation of the Neuroprotective Effect of Silymarin on Acrylamide-Induced Neurotoxicity

“…ACR conjugates with reduced glutathione (GSH) as the main antioxidant for detoxification. The ability of ACR to decrease antioxidant levels could be related, directly or indirectly, to its free-radicalproduction ability, thus leading to oxidative stress (3).…”

“…It also has an important application in laboratory research for the gel electrophoretic separation of molecules. Because of its wide application, people experience high levels of exposure (3). Additionally, ACR has been found in various thermally processed foods, such as potato chips, biscuits, and coffee.…”