The potential for endogenous myocardial antioxidants to protect the mycocardium against ischaemia-reperfusion injury: Refreshing the parts exogenous antioxidants cannot reach?

Steare, S.E.; Yellon, Derek M.

doi:10.1016/s0022-2828(08)80008-9

Cited by 45 publications

(29 citation statements)

References 60 publications

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“…Therapeutic strategies, designed to augment cellular endogenous defense systems such as antioxidants have been identified as a promising approach to combat doxorubicin toxicity [30]. According to our study, the oxidant enzyme concentrations in cardiac muscle were consistently reliably different in each experimental group and depended on aerobic exercise.…”

Section: Discussionmentioning

confidence: 54%

Effects of aerobic exercise on antioxidants in rat models with cardiomyopathy

Kim

2015

PTRS

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Objective: In this study, we aimed to test the hypothesis that aerobic exercise might exert its cardio-protective effect by preventing oxidative stress and improving cardiac function in rat models with doxorubicin-induced cardiomyopathy. Design: Randomized controlled trial. Methods: We randomly divided experimental rats into four groups: the normal group was used as a non-cardiomyopathy normal control (n=10); the control group included non-aerobic exercise after doxorubicin-induced cardiomyopathy (n=10); the experimental group I included aerobic exercise (3 m/min) after doxorubicin-induced cardiomyopathy (n=10); and experimental group II included aerobic exercise (8 m/min) after doxorubicin-induced cardiomyopathy. Rats in the treadmill training groups underwent treadmill training, which began at 2 weeks after the first intraperitoneal injection. At the end of the exercise period, we determined the heart weight change for each rat. Changes in the levels of oxidative stress enzymes (superoxide dismutase [SOD], thiobarbituric acid-reactive substances [TBARS], and catalase) in the cardiac tissue of rats from all four groups were examined at the end of the experiment. Results: Significant cardiac myocyte injury and increase in myocardial TBARS concomitant with a reduction in myocardial SOD and catalase were observed following cardiomyopathy (p<0.05). Significant cardiac tissue and increase in myocardial TBARS along with reduction in myocardial SOD and catalase were observed following cardiomyopathy (p<0.05). Oxidative parameters were significantly improved in the aerobic exercise groups compared with the control group. Conclusions: These findings indicate that aerobic exercise effectively prevents oxidative stress in rat models with cardiomyopathy.

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Section: Discussionmentioning

confidence: 54%

Effects of aerobic exercise on antioxidants in rat models with cardiomyopathy

Kim

2015

PTRS

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“…Numerous reports have indicated that antioxidant enzymes, including catalase, can be enhanced by sublethal experimental stimuli (25). However, as far as we know, this is the first report demonstrating that catalase activation can be achieved through endogenous systemic signaling pathways.…”

Section: Perspectivesmentioning

confidence: 75%

“…Therefore, it is presumed possible to develop practical measures to prevent or control those diseases through inhibition of oxidative cell damages. In this regard, many investigators have tried experimental approaches to reduce the oxidative damages (14,25). Some of these studies (14) adopted methods to suppress the generation of reactive oxygen metabolites or scavenge them by administration of exogenous antioxidant agents like SOD, catalase, or vitamin E. However, in many conditions, these exogenous agents hardly reach the target in active and stable forms, so that most of these studies have been far from satisfactory.…”

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confidence: 99%

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Involvement of adrenergic pathways in activation of catalase by myocardial ischemia-reperfusion

Kim

Chun

Park

et al. 2002

American Journal of Physiology-Regulatory, Integrative and Comp

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. Involvement of adrenergic pathways in activation of catalase by myocardial ischemia-reperfusion. Am J Physiol Regulatory Integrative Comp Physiol 282: R1450-R1458, 2002; 10.1152/ajpregu. 00278.2001.-In situ rabbit hearts were subjected to 15 min of regional myocardial ischemia, and at various time points of reperfusion, antioxidant enzyme activity and mRNA expression were measured in ischemic and nonischemic myocardium. Catalase activity increased significantly in both ischemic and nonischemic myocardium, peaking at 1 h after reperfusion and then gradually returning to the control level. Northern blot analysis showed enhanced expression of catalase mRNA in both areas. There were no changes in redox status, because glutathione levels were not altered by ischemia-reperfusion (I/R). We also tested whether catalase activation in the heart results from signaling pathways that might influence not only the heart but also other organs. We found that catalase activity in the brain was increased after myocardial I/R and ischemic stress to the intestine was equipotent to myocardial I/R in catalase activation. We next sought to elucidate the possible involvement of the adrenergic system in catalase stimulation induced by ischemic stimuli. After pretreatment with the ␣-adrenergic receptor antagonist prazosin, I/R failed to increase catalase activity in the heart and brain. Intravenous norepinephrine increased catalase activity in the heart, brain, and liver. This study shows that brief I/R activates a signaling mechanism to induce catalase activation in multiple organs and the ␣-adrenergic system is involved as an intermediate pathway in this signal transmission.antioxidant; adrenergic system REACTIVE OXYGEN METABOLITES, including superoxide anion, hydrogen peroxide, and hydroxyl radical, are continuously produced during metabolic processes of aerobic organisms, and sometimes the generation of reactive oxygen metabolites is accelerated by certain exogenous energy or chemicals, including radiation energy and some anticancer drugs. Reactive oxygen metabolites are highly reactive electrophiles, which may attack cellular constituents like protein, lipid, or nucleic acid, resulting in various abnormalities of structures and functions. In normal conditions, the small amount of reactive oxygen metabolites produced in metabolic processes is neutralized by the endogenous antioxidant defense system. The antioxidant system consists of antioxidant enzymes, including superoxide dismutase (SOD) and catalase, and nonenzymatic antioxidants, including glutathione, vitamin C, and vitamin E. However, when the balance between the production and the neutralization of reactive oxygen metabolites is deterred by certain causes, various patterns of oxidative cell injuries occur.

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“…There have been reports showing a close correlation between the production of ROS and simultaneous consumption of endogenous antioxidants 151,152 . Indirect evidence consistent with this view is the cardioprotective effects of free radical scavengers and antioxidant supplements 161,162,163 . New research finds that rats given oral low dose of quercetin significantly protected against the injury that normally occurs during ischemia and reperfusion 164 .…”

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confidence: 81%

Role of quercetin in cardiovascular diseases

Lakhanpal¹,

Kumar²

2008

Internet Journal of Medical Update - EJOURNAL

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Cardiovascular disease constitutes a major public health concern in industrialized nations. Over recent decades, a large body of evidence has accumulated indicating that oxidative stress induced free radicals play a critical role in cellular processes implicated in atherosclerosis and many other heart diseases. However a diet high in antioxidants is associated with a reduced risk of cardiovascular disease. The compound quercetin is a dietary antioxidant with a polyphenolic structure that is present in many foods, such as onion, apples, wine and tea. An increased intake of quercetin has been correlated with a decrease in the risk of cardiovascular diseases. Quercetin has been reported to exhibit a wide range of biological and pharmacological effects in animals and man besides its antioxidative and free radical scavenging actions. This paper reviews various steps of oxidative stress mediated atherogenesis and their signaling pathways and also emphasizes the role of quercetin in controlling oxidative stress and reducing the incidence of cardiovascular diseases.

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The potential for endogenous myocardial antioxidants to protect the mycocardium against ischaemia-reperfusion injury: Refreshing the parts exogenous antioxidants cannot reach?

Cited by 45 publications

References 60 publications

Effects of aerobic exercise on antioxidants in rat models with cardiomyopathy

Effects of aerobic exercise on antioxidants in rat models with cardiomyopathy

Involvement of adrenergic pathways in activation of catalase by myocardial ischemia-reperfusion

Role of quercetin in cardiovascular diseases

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