Role of quercetin in cardiovascular diseases

Abstract

Cardiovascular disease constitutes a major public health concern in industrialized nations. Over recent decades, a large body of evidence has accumulated indicating that oxidative stress induced free radicals play a critical role in cellular processes implicated in atherosclerosis and many other heart diseases. However a diet high in antioxidants is associated with a reduced risk of cardiovascular disease. The compound quercetin is a dietary antioxidant with a polyphenolic structure that is present in many foods, such as onion, apples, wine and tea. An increased intake of quercetin has been correlated with a decrease in the risk of cardiovascular diseases. Quercetin has been reported to exhibit a wide range of biological and pharmacological effects in animals and man besides its antioxidative and free radical scavenging actions. This paper reviews various steps of oxidative stress mediated atherogenesis and their signaling pathways and also emphasizes the role of quercetin in controlling oxidative stress and reducing the incidence of cardiovascular diseases.

Composition and Antioxidant Activity of Phenolic Compounds in Fruit of the Genus Rosa L.

“…These compounds are important for human health because of their strong antioxidant and anticancer activities [ 54 , 55 , 56 ]. The consumption of products rich in quercetin and its glycosides reduces the risk of cardiovascular [ 57 , 58 ] and neurodegenerative diseases [ 59 , 60 ].…”

Activity of trypsin-like enzymes and gelatinases in rats with doxorubicin cardiomyopathy

“…Low activity of both gelatinases in the cardiac muscle with application of corvitin may be accounted by the ability of bioflavonoid quercetin (main component of this drug) to inhibit ROS formation and lipid peroxidation (LPO) at different stages, to decrease MMP expression and increase synthesis of tissue inhibitor of metalloproteinases 1 (TIMP1). Quercetin inhibits also the synthesis of factor NF-κB, which leads to low level of pro-inflammatory cytokine TNF-α and, indirectly, to low gelatinases activity [19]. It was recently shown that quercetin may decrease the expression of gelatinases in coronary vessels through inhibition of JNK/AP-1 signaling pathway [20].…”

Lipoflavon® application for pharmacological correction of endothelial dysfunction in diabetic rats

“…На рівні ГМК під впливом кверцетину спостерігається активація ВК Са , яка може бути опосередкована як зв'язуванням кверцетину із естрогеновими рецепторами і подальшою стимуляцією каналів [17], так і за рахунок Н 2 О 2 -залежних сигнальних шляхів, адже кверцетин може виступати і як прооксидант [9]. Спостерігається інгі-бування протеїнкіназ, таких як ПКС і кіназа легких ланцюгів міозину [29], пригнічен-ня фосфоліпази А2 та супероксиддисмутазна активність [23].…”