The potential benefits of a garlic and hydrochlorothiazide combination as antihypertensive and cardioprotective in rats

Abstract

The purpose of the present study was to investigate the protective effects of combined therapy of garlic homogenate and hydrochlorothiazide (HCTZ) in animals with hypertension and myocardial damage. Three weeks of high fructose (10% w/v) in fluid to albino rats resulted in hypertension. They were subsequently administered garlic (125, 250 and 500 mg/kg, 3 weeks in separate groups) and HCTZ (10 mg/kg, 6th week) once daily in their respective groups. At the end of 6 weeks, myocardial damage was induced by subcutaneous administration of isoproterenol (175 mg/kg) for 2 consecutive days. The results showed that garlic and HCTZ increase the lactate dehydrogenase, creatinine phosphokinase, superoxide dismutase and catalase activities in heart homogenate when used concurrently or separately. Further, restoration of normal values in fluid/food intake, body weight, systolic blood pressure, cholesterol, triglycerides, glucose and histopathological scores were observed in all treated groups. Furthermore, histological disturbances and hypertension were significantly ameliorated in treated animals. Moreover, moderate dose of garlic was more effective than low dose, while a high dose of garlic was least effective in correcting electrocardiographic changes. Thus it is concluded that garlic in moderate dose (250 mg/kg) with added HCTZ possesses synergistic cardioprotective and antihypertensive properties against fructose- and isoproterenol-induced toxicities.

Effects of Micronutrient Fortifi ed Milk and Cereal Food for Infants and Children: A Systematic Review

“…In the present study, a fructose rich diet was used for the induction of diabetes, which is characterized by insulin resistance and metabolic syndrome very much similar to human type 2 diabetes mellitus. Previous studies have shown that longterm fructose feeding induces diabetes associated with insulin resistance and metabolic syndrome in experimental animals such as rats and mice [16,[24][25][26][27].…”

Garlic improves insulin sensitivity and associated metabolic syndromes in fructose fed rats

“…In the present study, a fructose rich diet was used for the induction of diabetes, which is characterized by insulin resistance and metabolic syndrome very much similar to human type 2 diabetes mellitus. Previous studies have shown that long-term fructose feeding induces diabetes associated with insulin resistance and metabolic syndrome in experimental animals such as rats and mice [16,24-27]. …”

Allium sativum

“…Moreover, combination of SACS and CAP exerted super-additive (synergistic) interaction with respect to fall in blood pressure and angiotensin-converting enzyme inhibition. They also found that garlic in moderate dose (250 mg/kg) with added HCTZ possessed synergistic cardioprotective and antihypertensive properties against fructose-and isoproterenolinduced toxicities in albino rats (Asdaq and Inamdar 2011b ). They also reported that the bioavailability and half-life of propranolol were signifi cantly enhanced by two-and threefold, respectively, in animals pretreated with 250 mg/ kg garlic homogenate (Asdaq and Inamdar 2011a ).…”