The potential applications of mushrooms against some facets of atherosclerosis: A review

Amirullah, Nur Amalina; Abidin, Nurhayati Zainal; Abdullah, Noorlidah

doi:10.1016/j.foodres.2017.11.023

Cited by 39 publications

(25 citation statements)

References 203 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These mice had increased Prevotellaceae in the cecum, similar to the increase in Prevotella in proximal colon of pigs fed WB mushrooms, but with additional members within the Bacteroidetes including Porphyromonadaceae , order Bacteroidales, Campylobacteriales within Proteobacteria, and Lactobacillales within Firmicutes with no major changes in the order Clostridiales [ 25 ]. Such differences may be explained by different dominant bacterial populations across anatomical sites (cecum vs. proximal colon vs. feces) [ 74 ], inherent features of the host, environmental factors such as diet and management or different compositions of mushrooms [ 1 ]. Moreover, the inferred microbiome metabolic data predicted an enrichment in carbohydrate metabolism, including galactose, fructose, mannose, starch, sucrose and galactose, glycan biosynthesis, tyrosine and histidine amino acid metabolism, and biosynthesis of steroids and secondary metabolites in pigs fed six servings of mushrooms.…”

Section: Discussionmentioning

confidence: 99%

“…However, it will need to be established if this effect is due directly to components of mushrooms or secondary metabolites derived from the intestinal microbiota. Many water, methanolic, and ethanolic extracts of mushrooms have been described to lower the production of inflammatory mediators by downregulating gene expression of these molecules [ 1 , 77 ]. A decrease in plasma levels of pro-inflammatory cytokines has been observed in IBD patients after oral intake of a mushroom extract isolated from a mixture of basidiomycetes mushrooms Agaricus blazei Murill, Hericium erinaceum , and Grifola frondosa.…”

Section: Discussionmentioning

confidence: 99%

“…Mushrooms contain many bioactive components including polysaccharides, glycoproteins, proteins, lipids, and secondary metabolites [ 1 ]. Polysaccharides composed of glucose, mannose, galactose, fucose, arabinose, glucuronic acid, and β- d -glucan are the most potent substances of mushrooms that show demonstrable beneficial properties such as antioxidant [ 2 ], immune-stimulatory [ 3 , 4 ] lipid lowering [ 5 , 6 ], and anti-tumor activity [ 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Effect of Dietary Mushroom Agaricus bisporus on Intestinal Microbiota Composition and Host Immunological Function

et al. 2018

View full text Add to dashboard Cite

A study was designed to determine the potential prebiotic effect of dietary mushrooms on the host immune response, and intestinal microbiota composition and function. Thirty-one six-week-old pigs were fed a pig grower diet alone or supplemented with either three or six servings of freeze-dried white button (WB)-mushrooms for six weeks. Host immune response was evaluated in peripheral blood mononuclear cells (PBMC), and alveolar macrophages (AM) after stimulation with Salmonella typhymurium-Lipopolysaccharide (LPS). Isolated DNA from fecal and proximal colon contents were used for 16S rDNA taxonomic analysis and linear discriminant analysis effect size (LEfSe) to determine bacterial abundance and metabolic function. Pigs gained weight with no difference in body composition or intestinal permeability. Feeding mushrooms reduced LPS-induced IL-1β gene expression in AM (P < 0.05) with no change in LPS-stimulated PBMC or the intestinal mucosa transcriptome. LEfSe indicated increases in Lachnospiraceae, Ruminococcaceae within the order Clostridiales with a shift in bacterial carbohydrate metabolism and biosynthesis of secondary metabolites in the mushroom-fed pigs. These results suggested that feeding WB mushrooms significantly reduced the LPS-induced inflammatory response in AM and positively modulated the host microbiota metabolism by increasing the abundance of Clostridiales taxa that are associated with improved intestinal health.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Effect of Dietary Mushroom Agaricus bisporus on Intestinal Microbiota Composition and Host Immunological Function

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Several reports on the release of bioelements and other organic compounds from food including mushrooms into artificial digestive juices were published, but study of bioavailability of lovastatin from mushroom is a new research direction [40][41][42][43]. It is well known that lovastatin is present in edible mushrooms from the Basidiomycota taxon, and their regular consumption can lead to lowering cholesterol levels and thus preventing from cardiovascular diseases [43,44]. There are, however, reports on the bioavailability of lovastatin present in red yeast rice products [45].…”

Section: Examination Of Lovastatin Release From Mycelium From the In mentioning

confidence: 99%

Fruiting bodies of selected edible mushrooms as a potential source of lovastatin

Kała

Kryczyk-Poprawa

Rzewińska

et al. 2020

Eur Food Res Technol

View full text Add to dashboard Cite

Agaricus bisporus, Cantharellus cibarius, Imleria badia, and Lentinula edodes are among the most popular species of edible mushrooms in Poland. These edible mushrooms are an important source of biologically active substances exhibiting beneficial (e.g., antioxidant, antitumor, antimicrobial, anti-inflammatory) effects on the human body. The fruiting bodies of edible mushrooms are also a valuable source of lovastatin, which belongs to a group of compounds, called statins, commonly used as cholesterol-lowering drugs. Due to the presence of lovastatin, edible mushrooms can be useful in the prevention of hypercholesterolemia. Therefore, the aim of this study was to determine the content of lovastatin in the selected species of edible mushrooms and to evaluate its release into artificial digestive juices. This study was the first to determine the release of lovastatin into digestive juices after the extraction of materials obtained from edible mushrooms. The largest amount of lovastatin was found in the fruiting bodies of C. cibarius (67.89 mg/100 g d.w.), and the smallest in those of L. edodes (0.95 mg/100 g d.w.). The amount of lovastatin released from the extracts of the examined species into digestive juices was found to be relatively low. The highest content after incubation in artificial gastric juice was detected for the fruiting bodies of L. edodes (0.02 mg/100 g d.w.) and after incubation in the intestinal juice for the mycelium from the in vitro cultures of L. edodes (0.51 mg/100 g d.w.). Thus, the results of the present study showed that due to its ability to accumulate lovastatin from culture medium, L. edodes mycelium can be used to obtain a product with increased hypolipidemic activity.

show abstract

“…Phenolic compounds, α-tocopherol and ergosterol all possess antioxidant activity [24,[29][30][31] and are found in higher concentrations in the extracts of mature fruiting bodies; however, many other unknown metabolites are probably involved. Although phenolics may prevent lipid peroxidation [32], lipophilic compounds such are tocopherols and ergosterol may show a greater effect in the β-carotene bleaching assay.…”

Section: Samplementioning

confidence: 99%

The impact of puffball autolysis on selected chemical and biological properties: Puffball extracts as potential ingredients of skin-care products

Petrović

Ivanović²,

Jovanović

et al. 2019

ARCH BIOL SCI BELGRA

View full text Add to dashboard Cite

Puffballs are fungi that produce globose fruiting bodies that undergo autolysis, transforming their insides into a spore bearing, powdery mass. Mature fruiting bodies are traditionally used to treat open skin wounds. In this study, methanol extracts of two puffball species, Handkea excipuliformis and Vascellum pratense, were examined and compared in order to provide insight into the changes these mushrooms undergo during maturation, with respect to their potential use in skin care and wound treatment. Some compounds involved in skin care and regeneration were quantified, and it was found that maturation increases the concentrations of almost all of these compounds. Antioxidant activity was also more pronounced in mature fruiting body extracts, which was in correlation with the higher content of antioxidants. Tyrosinase inhibition was vastly improved with autolysis, correlating with the higher phenolic content in mature fruiting body extracts. Antimicrobial activity was negatively affected by autolysis in the case of H. excipuliformis, whereas autolysis had little effect on the antimicrobial activity of V. pratense. Autolysis generally improved the biological activity and increased the concentrations of compounds involved in skin care, which justifies the traditional use of puffballs and makes them good candidates for various potential cosmetic and medicinal skin-care products.

show abstract

The potential applications of mushrooms against some facets of atherosclerosis: A review

Cited by 39 publications

References 203 publications

The Effect of Dietary Mushroom Agaricus bisporus on Intestinal Microbiota Composition and Host Immunological Function

The Effect of Dietary Mushroom Agaricus bisporus on Intestinal Microbiota Composition and Host Immunological Function

Fruiting bodies of selected edible mushrooms as a potential source of lovastatin

The impact of puffball autolysis on selected chemical and biological properties: Puffball extracts as potential ingredients of skin-care products

Contact Info

Product

Resources

About