The potential anti-osteoporotic effect of exercise—induced increased preptin level in ovariectomized rats

Abulfadle, Khaled Abdelfattah; Atia, Rania Refaat Abdelkader; Mohammed, Heba Osama; Ramadan, Rania; Mohammed, Nourelhuda A.

doi:10.1007/s12565-022-00666-7

Cited by 10 publications

(12 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…OPN is highly expressed in the bone and contributes to osteogenesis. A previous study reported that moderate exercise increased bone OPN expression and reduced osteoporotic alterations in ovariectomized rats [24].…”

Section: Introductionmentioning

confidence: 91%

Osteopontin May Improve Postinjury Muscle Repair Via Matrix Metalloproteinases And tgf-β Activation in Regular Exercise

Wang¹,

Luan²,

Jiang³

et al. 2023

Int. J. Med. Sci.

View full text Add to dashboard Cite

Skeletal muscle injuries are commonly observed during sports and trauma. Regular exercise promotes muscle repair; however, the underlying mechanisms require further investigation. In addition to exercise, osteopontin (OPN) contributes to skeletal muscle regeneration and fibrosis following injury. However, whether and how OPN affects matrix proteins to promote post-injury muscle repair remains uncertain. We recruited regular exercise (RE) and sedentary control (SC) groups to determine plasma OPN levels. Additionally, we developed a murine model of muscle contusion injury and compared the extent of damage, inflammatory state, and regeneration-related proteins in OPN knockout (OPN KO) and wild-type (WT) mice. Our results show that regular exercise induced the increase of OPN, matrix metalloproteinases (MMPs), and transforming growth factor-β (TGF-β) expression in plasma. Injured muscle fibers were repaired more slowly in OPN-KO mice than in WT mice. The expression levels of genes and proteins related to muscle regeneration were lower in OPN-KO mice after injury. OPN also promotes fibroblast proliferation, differentiation, and migration. Additionally, OPN upregulates MMP expression by activating TGF-β, which promotes muscle repair. OPN can improve post-injury muscle repair by activating MMPs and TGF-β pathways. It is upregulated by regular exercise. Our study provides a potential target for the treatment of muscle injuries and explains why regular physical exercise is beneficial for muscle repair.

show abstract

Section: Introductionmentioning

confidence: 91%

Osteopontin May Improve Postinjury Muscle Repair Via Matrix Metalloproteinases And tgf-β Activation in Regular Exercise

Wang¹,

Luan²,

Jiang³

et al. 2023

Int. J. Med. Sci.

View full text Add to dashboard Cite

show abstract

“…When compared to insulin, IGF1 and IGF2, preptin stimulated human osteoblasts cell proliferation at a lower level compared to IGFs, but to a greater extent than insulin, for which a proliferative effect was not observed on the short-term [62]. While higher ALP A very recent article published in 2023 reported decreased serum preptin levels, as well as increased bone turnover markers, in ovariectomized rats compared to controls [55]. However, serum preptin significantly increased in ovariectomized rats (1) treated with estradiol, (2) that practiced moderate exercise training or (3) that were treated with the anti-osteoporotic drug alendronate.…”

Section: What Do We Know From Experimental Datamentioning

confidence: 98%

“…Therefore, the anabolic bone effect of preptin is, at least partially, mediated via CTGF induction [53] and ERK activation (Figure 1). regulate the dynamics of peptin secretion [55]. Indeed, Root-Bernstein et al [56] described estradiol to interfere with insulin binding to its receptor, thus producing insulin resistance, which is known to be associated with a mount in preptin [57,58].…”

Section: What Do We Know From Experimental Datamentioning

confidence: 99%

Preptin: A New Bone Metabolic Parameter?

Ungureanu,

Bilha,

Hogas

et al. 2023

Metabolites

View full text Add to dashboard Cite

Preptin is a 34-aminoacid peptide derived from the E-peptide of pro-insulin-like growth factor 2 (pro-IGF2) that is co-secreted with insulin and upregulates glucose-mediated insulin secretion. High serum preptin levels were described in conditions associated with insulin resistance, such as polycystic ovary syndrome and type 2 diabetes mellitus (T2M). Insulin and also IGF2 are known to be anabolic bone hormones. The “sweet bone” in T2M usually associates increased density, but altered microarchitecture. Therefore, preptin was proposed to be one of the energy regulatory hormones that positively impacts bone health. Experimental data demonstrate a beneficial impact of preptin upon the osteoblasts. Preptin also appears to regulate osteocalcin secretion, which in turn regulates insulin sensitivity. Preptin is greatly influenced by the glucose tolerance status and the level of physical exercise, both influencing the bone mass. Clinical studies describe low serum preptin concentrations in osteoporosis in both men and women, therefore opening the way towards considering preptin a potential bone anabolic therapy. The current review addresses the relationship between preptin and bone mass and metabolism in the experimental and clinical setting, also considering the effects of preptin on carbohydrate metabolism and the pancreatic–bone loop.

show abstract

“…That study suggested exercise as a robust method for the improvement of osteoporosis in postmenopausal osteoporosis rat models through inhibiting bone resorption and promoting bone formation, particularly in trabecular bone ( 60 ). Similarly, another study reported that after 6 weeks of moderate exercise training with estradiol therapy of ovariectomized (OVX) rats, serum analysis showed a significant increase in bone resorption markers and bone formation markers, from osteocalcin (OCN) and bone-specific alkaline phosphatase (ALP) to proinflammatory cytokines such as TNF-α and IL-6 ( 55 ). Hence, moderate exercise training improved osteoporotic alterations in OVX rats by inflammatory change and showed a potential to be an effective therapeutic strategy for postmenopausal osteoporosis ( 55 ).…”

Section: Mechanisms Of Exercise On Bone Healthmentioning

confidence: 99%

Regulation of bone health through physical exercise: Mechanisms and types

Chang

Xu²,

Zhang³

2022

Front. Endocrinol.

View full text Add to dashboard Cite

Osteoporosis, characterized by bone mineral density reduction, bone mass loss, increased bone fragility, and propensity to fractures, is a common disease in older individuals and one of the most serious health problems worldwide. The imbalance between osteoblasts and osteoclasts results in the predominance of bone resorption and decreased bone formation. In recent years, it has been found that regular and proper exercise not only helps prevent the occurrence of osteoporosis but also adds benefits to osteoporosis therapy; accordingly, bone homeostasis is closely associated with mechanical stress and the intricate crosstalk between osteoblasts and osteoclasts. In this review, we summarize the mechanisms of exercise on osteoporosis and provide new proposals for the prevention and treatment of osteoporosis.

show abstract

The potential anti-osteoporotic effect of exercise—induced increased preptin level in ovariectomized rats

Cited by 10 publications

References 55 publications

Osteopontin May Improve Postinjury Muscle Repair Via Matrix Metalloproteinases And tgf-β Activation in Regular Exercise

Osteopontin May Improve Postinjury Muscle Repair Via Matrix Metalloproteinases And tgf-β Activation in Regular Exercise

Preptin: A New Bone Metabolic Parameter?

Regulation of bone health through physical exercise: Mechanisms and types

Contact Info

Product

Resources

About