The possible use of hypoxic preconditioning for the prophylaxis of post-stress depressive episodes

Рыбникова, Е. А.; Самойлов, М. О.; Mironova, V. I.; Tyulkova, E. I.; Pivina, S. G.; Vataeva, L. A.; Ordyan, N. É.; Abritalin, E. Yu.; Kolchev, A. I.

doi:10.1007/s11055-008-9038-x

Cited by 20 publications

(19 citation statements)

References 6 publications

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“…Three episodes of intermittent preconditioning using hypobaric hypoxia (360 mmHg, 2 h) prevented the onset of depressive behavioral reactions, hyperfunction of the hypophyseal-adrenal system and impairments in its suppression in the dexamethasone test in rats following unavoidable aversive stress in a model of endogenous depression (62). The authors consider that the data received indicate the possible use of hypoxic preconditioning for the prophylaxis of post-stress depressive episodes.…”

Section: Hypoxic Hypoxia As a General Protective Means: Animal Studiesmentioning

confidence: 94%

Trends in the use of preconditioning to hypoxia for early prevention of future life diseases

Basovich¹

2013

Biosci Trends

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Section: Hypoxic Hypoxia As a General Protective Means: Animal Studiesmentioning

confidence: 94%

Trends in the use of preconditioning to hypoxia for early prevention of future life diseases

Basovich¹

2013

Biosci Trends

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“…Rapid inhibition of stressful events is necessary to sustain stress responsiveness and minimize the adverse effects of stress. Delayed inhibition and prolonged stress can increase susceptibility to illness, including physical and behavioral disorders, e.g., cardiovascular disease, diabetes, allergy, and immune dysfunction, cancer, schizophrenia, Alzheimer's disease, and depression (Frieri 2003;Guglielmotto et al 2009;Halliwill 2003;Hopfl et al 2004;Lorita et al 2002;Lundberg 2005;Mikhailenko et al 2009;Rybnikova et al 2008;Schmidt-Kastner et al 2006;Semenza 2000b;Shuin et al 2006). Furthermore, early exposure to stress may have long-term consequences for growth and development, with the central nervous system being a particularly vulnerable target (Ducsay et al 2007;Mamet et al 2002;Marco et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Stress and Adrenergic Function: HIF1α, a Potential Regulatory Switch

et al. 2010

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Stress elicits adrenal epinephrine and cortisol release into the bloodstream to initiate physiological and behavioral responses to counter and overcome stress, the classic "fight or flight" response (Cannon and De La Paz, Am J Physiol 28:64-70, 1911). Stress and the stress hormone epinephrine also contribute to the pathophysiology of illness, e.g., behavioral disorders, cardiovascular disease, and immune dysfunction. Epinephrine itself is regulated by stress through its biosynthesis by phenylethanolamine N-methyltransferase (PNMT, EC 2.1.1.28). Single and repeated immobilization (IMMO) stress in rats stimulates adrenal PNMT mRNA and protein expression via the transcription factors, Egr-1 and Sp1. Moderate hypoxic stress increases PNMT promoter-driven gene expression and endogenous PNMT mRNA and protein in PC12 cells. Induction is initiated through cAMP and PLC signaling, with PKA, PKC, PI3K, ERK1/2 MAPK, and p38 MAPK continuing downstream signal transduction, followed by activation of HIF1α, Egr-1, and Sp1. While functional Egr-1 and Sp1 binding sites exist within the proximal PNMT promoter, a putative hypoxia response element is a weak HIF binding site. Yet, HIF1α overexpression increases PNMT promoter-driven luciferase activity and endogenous PNMT. When the Egr-1 or Sp1 sites are mutated, HIF1α does not stimulate the PNMT promoter. siRNA knock down of Egr-1 or Sp1 prevents promoter activation while siRNA knock down of HIF1α inhibits Egr-1 and Sp1 induction. Findings suggest that hypoxia activates the PNMT gene indirectly via HIF1α stimulation of Egr-1 and Sp1. Thus, for stress-induced illnesses where adrenergic dysfunction is implicated, HIF1α may be an "on-off" switch regulating adrenergic responses to stress and a potential target for therapeutic intervention.

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“…Preconditioning using mild intermittent HH (360 mmHg, 2 h) prevents inescapable footshock induced HPA axis hyperactivity and increases resistance to psychoemotional stresses resulting in marked anxiolytic and antidepressant effects in rats [46,47]. However, the longer duration of hypoxic exposure and extreme altitude results in opposing effects.…”

mentioning

confidence: 99%

Exposure to Hypobaric Hypoxia and Reoxygenation Induces Transient Anxiety-Like Behavior in Rat

Baitharu¹,

Jain²,

Deep³

et al. 2013

JBBS

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Chronic exposure to hypobaric hypoxia (HH) causes memory impairment and prolonged state of mental confusion. However, effect of high altitude exposure on mood state and its underlying mechanisms have been poorly studied. Present study was undertaken to investigate the mood state alteration following chronic exposure to HH. Male Sprague Dawley rats were divided into five groups and exposed to hypoxia for 3, 7, 14 and 21 days in an animal decompression chamber at an altitude of 25,000ft. Anxiety-and depression-like behaviors were assessed by using various mazes along with changes in serotonin and glutamate level. Our study revealed a decrease in exploratory, grooming and rearing behavior in open field test following initial exposure to HH for 7 days without affecting the locomotory behavior. Initial exposure to HH-decreased time spent in open arm of elevated plus maze indicating induction of anxiety-like behavior which normalized on prolonged hypoxic exposure for 21 days. Hypoxic exposure for 7 days induced anhedonia and increased despair behavior in rat while there was steady improvement in these behaviors when exposed for 21 days. Decrease in serotonin level was noted in hippocampus along with elevated corticosterone and glutamate level which gradually decreased on prolonged exposure to HH. These findings suggest that initial exposure to HH increases transient anxiety-like behavior in rats followed by gradual improvement in mood state on prolonged exposure. Further, the study also indicates the involvement of serotonergic system in mood state alteration at high altitude following chronic exposure and reoxygenation.

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The possible use of hypoxic preconditioning for the prophylaxis of post-stress depressive episodes

Cited by 20 publications

References 6 publications

Trends in the use of preconditioning to hypoxia for early prevention of future life diseases

Trends in the use of preconditioning to hypoxia for early prevention of future life diseases

Stress and Adrenergic Function: HIF1α, a Potential Regulatory Switch

Exposure to Hypobaric Hypoxia and Reoxygenation Induces Transient Anxiety-Like Behavior in Rat

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