The Possible Advantages of Cryoprecipitate Prepared From Fresh Frozen Plasma From Blood Stored for 24 Hours

Philip, Joseph; Samantha, Kumarage; Chatterjee, Tathagata; Kumar, Santosh; Mallhi, R.S.

doi:10.1309/lmv1e84uctrqqzp

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2023

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“…44,45 The cryoprecipitate should be used immediately, ideally within 4 hours of its being thawed and received from the blood bank, and should never be refrozen. 27,[46][47][48] The shelf life of thawed cryoprecipitate is short due to the loss of clotting factor activity, particularly that of factor VIII.…”

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confidence: 99%

Use of Cryoprecipitate in Newborn Infants

Maheshwari¹,

Tyagi²,

Guaragni³

et al. 2023

Newborn

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Cryoprecipitate is a transfusion blood product derived from fresh-frozen plasma (FFP), comprised mainly of the insoluble precipitate that gravitates to the bottom of the container when plasma is thawed and refrozen. It is highly enriched in coagulation factors I (fibrinogen), VIII, and XIII; von Willebrand factor (vWF); and fibronectin. In this article, we have reviewed currently available information on the preparation, properties, and clinical importance of cryoprecipitate in treating critically ill neonates. We have searched extensively in the databases PubMed, Embase, and Scopus after short-listing keywords to describe the current relevance of cryoprecipitate.

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