It appears from our data that OPG serum levels in healthy children aged > 4 years are similar to those present in young adult men, with higher levels in the first 4 years of life. Although the meaning of the alterations of OPG levels observed in pathological conditions is still obscure, they appear potentially interesting in view of a key role played by this protein in bone homeostasis.
Neonatal bleeding or thrombosis are serious problems and life threatening events. The diagnostic approach needs to consider the theory of the “developmental hemostasis” for interpreting blood tests. The causes, diagnosis and management of the main neonatal hemostatic abnormalities will be reviewed.
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