The Possibility of Ultrasonic Cancer Therapy and Some of the Difficulties

Abstract

Biophysical modes of ultrasound are classified as follows : 1) thermal effects, 2) cavitational effects, 3) the other nonthermal and noncavitational effects. There have been three approaches to cancer therapy with ultrasound : studies have sought to measure the effects of ultrasound alone on tumors, ultrasound in combination with radiotherapy, and ultrasound in combination with chemotherapy.In this paper we will review and discuss the implications of the nonthermal effects of ultrasound when ultrasound is combined with heat, ionizing radiation, and chemotherapeutic agents, on the basis of the current reports related to ultrasonic cancer therapy and the biological effects of ultrasound.

Enhanced cavitation dose and reactive oxygen species production in microbubble-mediated sonodynamic therapy for inhibition of Escherichia coli and biofilm

“…the depth of laser action is limited. Consequently, an alternative method named sonodynamic therapy (SDT) has attracted much attention [22] , [23] , [24] , [25] , [26] , [27] . Researchers have found that both the sole use of ultrasound and its combination with other antimicrobial methods exhibit excellent inhibitory effects on various microorganisms, such as bacteria, fungi, and viruses [26] , [27] , [28] , [29] , [30] , [31] , [32] .…”