Enhanced cavitation dose and reactive oxygen species production in microbubble-mediated sonodynamic therapy for inhibition of Escherichia coli and biofilm

Li, Changlong; Teng, Fengmeng; Wu, Fengmin; Zhang, Hui; Zhang, Chunbing; Zhang, Dong

doi:10.1016/j.ultsonch.2024.106853

Cited by 3 publications

(1 citation statement)

References 41 publications

(41 reference statements)

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“…The extracellular ultrasound-induced ROS production of REPNs was detected using DPBF as an indicator. 24,25 A series of REPNs and RB samples with different RB concentrations ( C RB = 0, 2, 4, 6, 8, 10 μg mL −1 ) were prepared, and 200 μL of them were respectively added into a 96-well plate in triplicate. DPBF was then dissolved in acetonitrile at a concentration of 2 mg mL −1 , and 2 μL was added per well.…”

Section: Methodsmentioning

confidence: 99%

Integrin α_vβ₃-targeted self-assembled polypeptide nanomicelles for efficacious sonodynamic therapy against breast cancer

Ren,

Yang,

Kong

et al. 2024

Nanoscale

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Section: Methodsmentioning

confidence: 99%

Integrin α_vβ₃-targeted self-assembled polypeptide nanomicelles for efficacious sonodynamic therapy against breast cancer

Ren,

Yang,

Kong

et al. 2024

Nanoscale

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Reactive oxygen species responsive chitooligosaccharides based nanoplatform for sonodynamic therapy in mammary cancer

Sun,

Luo,

et al. 2024

Carbohydrate Polymers

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Core–Shell Rare Earth Nanoparticles for Photochemo-Dynamic Cancer Theranostics under NIR Excitation

Ju,

Wang,

Shi

et al. 2024

ACS Appl. Nano Mater.

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Photodynamic therapy (PDT) is an effective strategy for cancer treatment, which offers advantages such as rapid effectiveness, low toxicity, and minimal trauma. However, one of the key components of PDT, photosensitizers, typically requires excitation by ultraviolet or visible light to function, which limits the application of this therapy to some extent. To address the above issues, in this research, a composite material UCNPs@SiO2–ZnPc-Fe(OH)3 (USZ-Fe(OH)3) was prepared for photochemo-dynamic therapy (PCDT) based on rare earth upconversion nanoparticles (UCNPs). To enhance the upconversion fluorescence intensity, a layer of inert shell was coated on the original nanoparticles, resulting in core–shell–shell-structured UCNPs of NaYF4:Yb,Er@NaYF4:Nd@NaYF4. A layer of SiO2 was coated on the above UCNPs in order to improve their biocompatibility, followed by loading the photosensitizer ZnPc to prepare UCNPs@SiO2–ZnPc (USZ) for PCDT of oral squamous cell carcinoma (OSCC). Finally, Fe(OH)3 was loaded on the surface of USZ through electrostatic adsorption to obtain USZ-Fe(OH)3, with the aim of improving the hypoxic environment in solid tumors and achieving the effectiveness of PCDT. In vitro and in vivo experiments demonstrated the composite material USZ-Fe(OH)3 exhibited excellent therapeutic effects in PCDT for OSCC. Moreover, a deep learning model of the ResNet18 network was used to detect the pathology of the tumor area from mice treated with PCDT and those from the control group. All of the results indicate the proposed PCDT platform in this work presented excellent performance in tumor treatment.

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Enhanced cavitation dose and reactive oxygen species production in microbubble-mediated sonodynamic therapy for inhibition of Escherichia coli and biofilm

Cited by 3 publications

References 41 publications

Integrin α_vβ₃-targeted self-assembled polypeptide nanomicelles for efficacious sonodynamic therapy against breast cancer

Integrin α_vβ₃-targeted self-assembled polypeptide nanomicelles for efficacious sonodynamic therapy against breast cancer

Reactive oxygen species responsive chitooligosaccharides based nanoplatform for sonodynamic therapy in mammary cancer

Core–Shell Rare Earth Nanoparticles for Photochemo-Dynamic Cancer Theranostics under NIR Excitation

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Enhanced cavitation dose and reactive oxygen species production in microbubble-mediated sonodynamic therapy for inhibition of Escherichia coli and biofilm

Cited by 3 publications

References 41 publications

Integrin αvβ3-targeted self-assembled polypeptide nanomicelles for efficacious sonodynamic therapy against breast cancer

Integrin αvβ3-targeted self-assembled polypeptide nanomicelles for efficacious sonodynamic therapy against breast cancer

Reactive oxygen species responsive chitooligosaccharides based nanoplatform for sonodynamic therapy in mammary cancer

Core–Shell Rare Earth Nanoparticles for Photochemo-Dynamic Cancer Theranostics under NIR Excitation

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Product

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Integrin α_vβ₃-targeted self-assembled polypeptide nanomicelles for efficacious sonodynamic therapy against breast cancer

Integrin α_vβ₃-targeted self-assembled polypeptide nanomicelles for efficacious sonodynamic therapy against breast cancer