The possibility of polymorphonuclear leukocyte activation in dental socket healing by freeze-dried Aloe vera induction

Abstract

Background: Research has proved that Aloe vera has anti-inflammatory, anti-bacterial, and immunomodulator properties that can accelerate the healing process. These properties could be beneficial in the tooth extraction wound-healing process. Neutrophils are the first inflammatory cells to invade and are the predominant cell markers in the wound for 24 hours after injury. Polymorphonuclear leukocytes (PMN) provide initial protection against micro-organisms, as they engulf and digest foreign bodies. Purpose: The aim of this study was to prove the effect of Aloe vera 90% gel application on the PMN count in the healing process of Cavia cobaya following tooth extraction. Methods: This laboratory experimental research was done using Post-Test Only Control Group Design. The lower incisive of twelve male Cavia cobayas were extracted then divided into four groups. Group P1 and P3 had 90% Aloe vera gel applied into the socket and sutured; group K1 and K3, received no 90% Aloe vera gel application and acted as controls. Samples from group P1 and K1 were terminated and had their mandibula taken one day after tooth extraction, and those from group P3 and K3 were terminated after three days. Tissues were then processed into histology slides, and PMN cells were counted. Results: There were significant differences in the PMN count between groups K1, P1, and K3 compared with P3 (p < 0.05). Higher PMN count was shown on the group containing Aloe vera 90% gel compared with control group, both on day one and three after tooth extraction. Conclusion: Aloe vera 90% gel can increase the PMN count in the inflammation phase of the tooth extraction wound-healing process.

Aloe Vera aqueous extract and yogurt enhance peripheral immune cells, and brain astrocytes response in rats.

“…The enhanced neutrophil count was opposed by a relative reduction in lymphocyte count in the same group. Likewise, similar results were achieved by a previous investigation that showed an enhanced polymorphonuclear cells count by higher concentrations of Aloe Vera (Soesilawati et al, 2021). The neutrophil count is relatively increased without further change in the total leukocytic count (Bala et al, 2019).…”

“…The aqueous extract of Aloe Vera promotes secondary humoral immunity mediated by B and T lymphocytes (Zanuzzo et al, 2017). Moreover, high concentrations of Aloe Vera were found to enhance the proliferation of polymorphonuclear cells including neutrophils, eosinophils, and basophils during an inflammatory response (Soesilawati et al, 2021). The action of Aloe Vera on immune cells is type-specific since it can enhance the relative count of neutrophils without further change in the total leukocytic count (Bala et al, 2019).…”

The diagnostic challenges and two-step surgical approach to an infected dentigerous cyst resembling a unicystic ameloblastoma: A case report

“…However, when the histopathologic examination uncovers a cyst, the treatment plan involves enucleation or marsupialization. 23,24 This case report highlighted an extensive dentigerous cyst related to an impacted left mandibular third molar. The patient presented with a pus-filled lump that could be diagnosed as a neoplasm, cyst, or infection.…”

Aloe Vera for Protects Skin Tissues from The Damaging Impacts of Ultraviolet Radiation

“…It might be safe to administer appropriate doses orally for a short time. [22]This has inspired the design of several biomaterials for burn and wound healing to incorporate Aloe vera as a strategy [23][24].…”