The porcine stress linkage group

Zeveren, Alex Van; Weghe, Alex Van De; Bouquet, Y.; Varewyck, H.

doi:10.1111/j.1439-0388.1988.tb00289.x

Cited by 4 publications

(4 citation statements)

References 22 publications

(3 reference statements)

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“…Due to restriction of the material to unrelated parents no PGD A ‐Hal n association is present in DLM and, hence, the estimate of Ds reaches the maximal value. Essentially, our results correspond with those reported earlier for different breeds (J orgensen 1977; G ahne and J uneja 1985; E iffert et al 1985; V an Z everen et al 1988c; V ögeli et al 1988), but presumably, due to a smaller sample size, some associations (A1B/Hal, PGD/Hal) are slightly stronger. However, deviating from the results mentioned is the obviously loose relationship between GPI and all other loci, in particular the halothane locus for which Ds‐values between .6‐1.0 have been usually reported.…”

Section: Resultssupporting

confidence: 93%

“…Therefore this approach appears questionable. Evident discrepancy between the lines in the intensity of linkage has been extensively discussed by V an Z everen et al (1988c) for Belgian Landrace. To improve the accuracy of marker assisted selection they proposed an increase of already existing linkage disequilibria to the maximal values by exclusive selection of animals with favourable marker‐halothane haplotypes.…”

Section: Methodsmentioning

confidence: 99%

“…Thus, polymorphic markers like A1BG and PGD may be more, or sometimes only, valuable for family analysis. If recombination occurs in frequencies as in the Hal‐linkage group (V an Z everen et al 1988a), relatively stable transmission of parental, haplotypes to offspring would be ensured or, if it happened, probably be detected (V ögeli et al 1988). Accuracy of haplotyping for prediction of Hal‐genotypes has been reported to be 90‐95% (G ahne and J uneja 1985).…”

Section: Methodsmentioning

confidence: 99%

“…The product of the locus PO2 has been found homologous to human α 1 B‐glycoprotein (J uneja et al 1987) and is now designated ***A1BG. The gene order of the linkage group is S‐Hal‐GPI‐H‐***A1BG‐PGD (van Z everen et al 1988a, b; V ögeli 1989). Use of markers to diagnose halothane genotypes has had mixed results in different populations because of different linkage relationships and low frequencies of favourably linked allels (e. g. A ndresen 1979; A ndresen et al 1981; E iffert et al 1985; G lodek et al 1985; van Z everen et al 1988c).…”

Section: Introductionmentioning

confidence: 99%

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Associations between blood marker loci and stress susceptibility in pigs

Ruß¹,

Duda²,

Pirchner³

1992

J Animal Breeding Genetics

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Summary Associations between blood marker and stress susceptibility in pigs as indicated by halothane reaction and log CK‐activity are characterized in three selection lines (DLM, DLK, Pietrain). Strong linkage disequilibria varying in direction and extent between the lines were found in DLK and DLM, but not for Pietrain. Thus, A1BSS is associated with about 75% of the Hallnn genotypes in the DLK and PGDBB with about 89% of these in the DLM. The GPI‐system appeared not to be suitable for marker analysis. Application of markers to selection of stress resistant animals is more efficient since no positive reagents and only 1% heterozygous animals are found in the A1BFF/PGDAA‐genotype combinatin. Combining marker alleles to haplotypes is superior in accuracy and efficiency to the use of marker genotypes for identification of halothane genotypes. Gene effects of marker‐ and halothane loci on log CK‐activity have been estimated. Independent of the dominating influence of Haln (a = 0.6) marker alleles A1BF and PGDB affect CK‐activity desirably by additive and epistatic gene effects. Linkage with an other loci might be considered as cause of this. Zusammenfassung Zusammenhänge zwischen Blutmarkersystemen und Streßanfälligkeit bei Schweinen Die Zusammenhänge zwischen Blutmarkersystemen und Streßanfälligkeit beim Schwein, die durch Halothangenotypen und log CK‐Aktivität repräsentiert wird, wurden in drei Schweineselektionslinien (DLK, DLM, Pietrain) festgestellt. Während in der Pietrainlinie keine Zusammenhänge zu finden sind, wurden Kopplungsungleichgewichte zwischen Marker‐ und Halothangenotypen bei DL gefunden, die jedoch in Ausmaß und Richtung zwischen den Linien differieren. Mit Hilfe von A1BSS könnten etwa 75% der Halnn‐Genotypen in der DLK und mit PGDBB 89% in der DLM erfaßt werden. Das GPI‐System erwies sich als unbrauchbar zur Anwendung bei markergestützten Selektionsmaßnahmen. Die Marker würden sich wesentlich besser zur Selektion von homozygot resistenten Tieren eignen, da in der A1BFF/PGDAA Genotypenkombination keine halothan‐positive und nur etwa 1% halothan‐heterozygote Tiere zu finden sind. Die Verknüpfung von Markerallelen zu Haplotypen ist geeigneter zur Bestimmung der Halothangenotypen. Durch Trennung von Marker‐ und Halothangenotypeffekten konnten Geneffekte auf die log CK‐Aktivität geschätzt werden. Unabhängig von der dominierend erhöhenden Wirkung durch Haln (a = 0.6), beeinflussen die Markergenotypen A1BF und PGDA die CK‐Aktivität im züchterisch positiven Sinn mit additiven und epistatischen Genwirkungen. Als Ursache wurde Kopplung mit einem weiteren Locus der Synthäniegruppe für möglich erachtet.

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Section: Resultssupporting

confidence: 93%

Section: Methodsmentioning

confidence: 99%