The homology between the serum proteins Po2 in pig, Xk in horse and α1B-glycoprotein in human

Weghe, Alex Van De; Coppieters, Wouter; Bauw, Guy; Vandekerckhove, Joël; Bouquet, Y.

doi:10.1016/0305-0491(88)90330-6

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1990

1991

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“…The Po2 locus is closely linked to the stress susceptibility (Hal) locus (for a review see Archibald & Imlah 1985) and is therefore of interest since its isolation would allow a starting point for genomic walking towards the Hal locus. A genomic pig library was constructed and screened with an oligonucleotide, complementary to the partial N-terminal sequence of PO2 (Van de Weghe et al 1988). A false positive clone which reproducibly hybridizes to the oligonucleotide was picked up and revealed after sequencing to contain a tandem repeat.…”

Section: Introductionmentioning

confidence: 99%

A hypervariable pig DNA fragment

et al. 1990

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Section: Introductionmentioning

confidence: 99%

A hypervariable pig DNA fragment

et al. 1990

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Amino acid substitution matrices from an information theoretic perspective

Altschul

1991

Journal of Molecular Biology

531

380

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Protein sequence alignments have become an important tool for molecular biologists. Local alignments are frequently constructed with the aid of a "substitution score matrix" that specifies a score for aligning each pair of amino acid residues. Over the years, many different substitution matrices have been proposed, based on a wide variety of rationales. Statistical results, however, demonstrate that any such matrix is implicitly a "log-odds" matrix, with a specific target distribution for aligned pairs of amino acid residues. In the light of information theory, it is possible to express the scores of a substitution matrix in bits and to see that different matrices are better adapted to different purposes. The most widely used matrix for protein sequence comparison has been the PAM-250 matrix. It is argued that for database searches the PAM-120 matrix generally is more appropriate, while for comparing two specific proteins with suspected homology the PAM-200 matrix is indicated. Examples discussed include the lipocalins, human alpha 1 B-glycoprotein, the cystic fibrosis transmembrane conductance regulator and the globins.

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The homology between the serum proteins Po2 in pig, Xk in horse and α1B-glycoprotein in human

Cited by 2 publications

References 13 publications

A hypervariable pig DNA fragment

A hypervariable pig DNA fragment

Amino acid substitution matrices from an information theoretic perspective

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