The Polysaccharide of the Vitreous Humor

Meyer, Karl; Palmer, John W.

doi:10.1016/s0021-9258(18)75338-6

Cited by 793 publications

(110 citation statements)

References 6 publications

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“…Polysaccharides 2021, 2,5 the dihydropyran ring and forming a nitrogen-iridoid. The results suggested that HA-ADH improved the cross-linking efficiency of genipin, producing hydrogels with enhanced mechanical resistance, and the water absorption and degradation rate were reduced [72].…”

Section: Partial Oxidation Of Hyaluronic Acid (Oxi-ha)mentioning

confidence: 99%

“…Hyaluronic acid (HA) is a glycosaminoglycan comprising repeating disaccharide units of glucuronic acid and N-acetylglucosamine that is widely distributed in the extracellular matrix (ECM) and plays a vital role in vertebrate tissue morphogenesis [1]. Isolated first in 1934 by Meyer and Palmer [2], HA has an evolutionary history supported by profound structural, physicochemical, and biological studies that resulted in an extensive network of clinical applications in the late 20th century. Laurent [3] summarized HA history research in the form of a tree, in which the great stages of development mark the trunk.…”

Section: Introductionmentioning

confidence: 99%

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Oxi-HA/ADH Hydrogels: A Novel Approach in Tissue Engineering and Regenerative Medicine

2021

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Hyaluronic acid (HA) is a natural polyelectrolyte abundant in mammalian connective tissues, such as cartilage and skin. Both endogenous and exogenous HA produced by fermentation have similar physicochemical, rheological, and biological properties, leading to medical and dermo-cosmetic products. Chemical modifications such as cross-linking or conjugation in target groups of the HA molecule improve its properties and in vivo stability, expanding its applications. Currently, HA-based scaffolds and matrices are of great interest in tissue engineering and regenerative medicine. However, the partial oxidation of the proximal hydroxyl groups in HA to electrophilic aldehydes mediated by periodate is still rarely investigated. The introduced aldehyde groups in the HA backbone allow spontaneous cross-linking with adipic dihydrazide (ADH), thermosensitivity, and noncytotoxicity to the hydrogels, which are advantageous for medical applications. This review provides an overview of the physicochemical properties of HA and its usual chemical modifications to better understand oxi-HA/ADH hydrogels, their functional properties modulated by the oxidation degree and ADH concentration, and the current clinical research. Finally, it discusses the development of biomaterials based on oxi-HA/ADH as a novel approach in tissue engineering and regenerative medicine.

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Section: Partial Oxidation Of Hyaluronic Acid (Oxi-ha)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Oxi-HA/ADH Hydrogels: A Novel Approach in Tissue Engineering and Regenerative Medicine

2021

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“…Hyaluronan (sodium salt of hyaluronic acid, NaHy), was firstly obtained by Meyer et al [1] from the vitreous humor of cattle eyes. It consists of a disaccharide repeating sequence of D-glucuronic acid and N-acetyl-D-glucosamine, linked via alternating β-(1→4) and β-(1→3) glycosidic bonds ( Figure 1) [2].…”

Section: Introductionmentioning

confidence: 99%

Effect of Hofmeister Ions on Transport Properties of Aqueous Solutions of Sodium Hyaluronate

Musilová

Mráček

Kašpárková

et al. 2021

IJMS

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Tracer diffusion coefficients obtained from the Taylor dispersion technique at 25.0 °C were measured to study the influence of sodium, ammonium and magnesium salts at 0.01 and 0.1 mol dm−3 on the transport behavior of sodium hyaluronate (NaHy, 0.1%). The selection of these salts was based on their position in Hofmeister series, which describe the specific influence of different ions (cations and anions) on some physicochemical properties of a system that can be interpreted as a salting-in or salting-out effect. In our case, in general, an increase in the ionic strength (i.e., concentrations at 0.01 mol dm−3) led to a significant decrease in the limiting diffusion coefficient of the NaHy 0.1%, indicating, in those circumstances, the presence of salting-in effects. However, the opposite effect (salting-out) was verified with the increase in concentration of some salts, mainly for NH4SCN at 0.1 mol dm−3. In this particular salt, the cation is weakly hydrated and, consequently, its presence does not favor interactions between NaHy and water molecules, promoting, in those circumstances, less resistance to the movement of NaHy and thus to the increase of its diffusion (19%). These data, complemented by viscosity measurements, permit us to have a better understanding about the effect of these salts on the transport behaviour of NaHy.

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“…The bioactivity of the anionic glycosaminoglycan HA (pk a ¼ 3.36) is based both on physical and chemical properties (8,9). The outstanding rheological properties as a hydrogel designate HA as a structural component in tissue and joints, which is reflected in enrichment in the synovial fluid and the vitreous humor, where it enhances the biomechanical stability (10)(11)(12). Interestingly, when HA is applied as coating, it prevents postsurgery adhesion of microorganisms and inflammation as it has been shown in animal studies (1).…”

Section: Introductionmentioning

confidence: 99%

Shear Stress Regulates Adhesion and Rolling of CD44+ Leukemic and Hematopoietic Progenitor Cells on Hyaluronan

Christophis

Taubert

Meseck

et al. 2011

Biophysical Journal

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Leukemic cells and human hematopoietic progenitor cells expressing CD44 receptors have the ability to attach and roll on hyaluronan. We investigated quantitatively the adhesion behavior of leukemic cell lines and hematopoietic progenitor cells on thin films of the polysaccharides hyaluronan and alginate in a microfluidic system. An applied flow enhances the interaction between CD44-positive cells and hyaluronan if a threshold shear stress of 0.2 dyn/cm(2) is exceeded. At shear stress ∼1 dyn/cm(2), the cell rolling speed reaches a maximum of 15 μm/s. Leukemic Jurkat and Kasumi-1 cells lacking CD44-expression showed no adhesion or rolling on the polysaccharides whereas the CD44-expressing leukemic cells KG-1a, HL-60, K-562, and hematopoietic progenitor cells attached and rolled on hyaluronan. Interestingly, the observations of flow-induced cell rolling are related to those found in the recruitment of leukocytes to inflammatory sites and the mechanisms of stem-cell homing into the bone marrow.

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The Polysaccharide of the Vitreous Humor

Cited by 793 publications

References 6 publications

Oxi-HA/ADH Hydrogels: A Novel Approach in Tissue Engineering and Regenerative Medicine

Oxi-HA/ADH Hydrogels: A Novel Approach in Tissue Engineering and Regenerative Medicine

Effect of Hofmeister Ions on Transport Properties of Aqueous Solutions of Sodium Hyaluronate

Shear Stress Regulates Adhesion and Rolling of CD44+ Leukemic and Hematopoietic Progenitor Cells on Hyaluronan

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