The Polyphenols as Potential Agents in Prevention and Therapy of Prostate Diseases

Pejcic, T.; Tosti, Tomislav; Džamić, Zoran; Gašić, Uroš; Vuksanović, Aleksandar; Dolićanin, Zana; Tešić, Živoslav Lj.

doi:10.3390/molecules24213982

Cited by 23 publications

(22 citation statements)

References 217 publications

(226 reference statements)

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“…Literature data indicate that plant polyphenols are effective in preventing and inhibiting the growth of gastrointestinal neoplasms, where they are found in the highest amounts after consumption. They are also effective in the case of colorectal neoplasms [ 51 ] and contribute to the inhibition of the development of many other neoplasms, e.g., melanoma, prostate and hormone-dependent tumors [ 54 , 90 ]. Furthermore, research indicates that polyphenols, such as apigenin, quercetin, resveratrol or gallic acid, have anti-angiogenetic properties [ 91 ].…”

Section: Classes Of Phenolic Compounds and Their Biological Role Fmentioning

confidence: 99%

Beneficial Effects of Phenolic Compounds on Gut Microbiota and Metabolic Syndrome

Kasprzak-Drozd

Oniszczuk

Stasiak

et al. 2021

IJMS

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The human intestine contains an intricate community of microorganisms, referred to as the gut microbiota (GM), which plays a pivotal role in host homeostasis. Multiple factors could interfere with this delicate balance, including genetics, age, medicines and environmental factors, particularly diet. Growing evidence supports the involvement of GM dysbiosis in gastrointestinal (GI) and extraintestinal metabolic diseases. The beneficial effects of dietary polyphenols in preventing metabolic diseases have been subjected to intense investigation over the last twenty years. As our understanding of the role of the gut microbiota advances and our knowledge of the antioxidant and anti-inflammatory functions of polyphenols accumulates, there emerges a need to examine the prebiotic role of dietary polyphenols. This review firstly overviews the importance of the GM in health and disease and then reviews the role of dietary polyphenols on the modulation of the gut microbiota, their metabolites and how they impact on host health benefits. Inter-dependence between the gut microbiota and polyphenol metabolites and the vital balance between the two in maintaining the host gut homeostasis are also discussed.

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Section: Classes Of Phenolic Compounds and Their Biological Role Fmentioning

confidence: 99%

Beneficial Effects of Phenolic Compounds on Gut Microbiota and Metabolic Syndrome

Kasprzak-Drozd

Oniszczuk

Stasiak

et al. 2021

IJMS

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“…On the other hand, the intake of long-chain omega-3 polyunsaturated fatty acids does not seem to be associated with lower cancer incidence (26). Vitamin D could also play an important role, as both low and high concentrations are associated with an increased risk (29).…”

Section: Prostate Cancermentioning

confidence: 99%

Polyphenols in cancer prevention: New insights (Review)

et al. 2020

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A huge volume of literature data suggests that a diet rich in fruits and vegetables, mostly due to the contribution of natural polyphenols, could reduce the incidence of specific cancers. Resveratrol, epigallocatechin gallate and curcumin are among the most extensively studied polyphenols: The majority of the effects attributed to these compounds are linked to their antioxidant and anti-inflammatory properties. The multiple mechanisms involved include the modulation of molecular events and signaling pathways associated with cell survival, proliferation, differentiation, migration, angiogenesis, hormonal activities, detoxification enzymes and immune responses. Notwithstanding their promising role in cancer prevention and treatment, polyphenols often have a poor bioavailability when administered as pure active principles, representing an important limit to their use. However, the bioavailability and thus the efficacy of these compounds can be improved by their administration in combination with other phytochemicals, with anticancer drugs or in polyphenol-loaded nanotechnology-based delivery systems. The possibility of combining conventional drugs with polyphenols offers very valuable advantages, such as the building of more efficient anticancer therapies with less side-effects on the health of patients. The present review focuses on current knowledge regarding the interactions between natural polyphenols and cancer development in order to gain a clearer comprehension of the potential mechanisms through which individual foods and food components may be exploited to reduce cancer risk. Contents 1. Introduction 2. Literature search 3. Classification of polyphenols 4. Prostate cancer 5. Colon cancer 6. Breast cancer 7. Lung cancer 8. Bladder cancer 9. Skin cancer 10. Pancreatic cancer 11. Leukemia 12. Conclusion

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“…Regarding the relationship between isoflavones and prostate diseases, research has reported that isoflavones exert a preventive effect on prostate carcinogenesis due to their phytoestrogen action [ 16 ]. In addition, many investigators have paid special attention to the anti-cancer effects of isoflavones in prostate cancer [ 67 , 68 , 69 ]. In contrast to prostate cancer, studies on the pharmacological effects of isoflavones on BPH are smaller.…”

Section: Management Of Benign Prostate Hyperplasia With Polyphenolmentioning

confidence: 99%

“…Interestingly, this study also showed that there were no significant differences in plasma levels of luteinizing hormone (LH) or the estradiol and testicular levels of testicular steroidogenic acute regulatory peptide between the phytoestrogen-rich included isoflavones and the phytoestrogen-free Regarding the relationship between isoflavones and prostate diseases, research has reported that isoflavones exert a preventive effect on prostate carcinogenesis due to their phytoestrogen action [16]. In addition, many investigators have paid special attention to the anti-cancer effects of isoflavones in prostate cancer [67][68][69]. In contrast to prostate cancer, studies on the pharmacological effects of isoflavones on BPH are smaller.…”

Section: Isoflavonesmentioning

confidence: 99%

Pharmacological Effects and Potential Clinical Usefulness of Polyphenols in Benign Prostatic Hyperplasia

et al. 2021

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Benign prostatic hyperplasia (BPH) is arguably the most common benign disease among men. This disease is often associated with lower urinary tract symptoms (LUTS) in men and significantly decreases the quality of life. Polyphenol consumption reportedly plays an important role in the prevention of many diseases, including BPH. In recent years, in addition to disease prevention, many studies have reported the efficacy and safety of polyphenol treatment against various pathological conditions in vivo and in vitro. Furthermore, numerous studies have also revealed the molecular mechanisms of the antioxidant and anti-inflammatory effects of polyphenols. We believe that an improved understanding of the detailed pharmacological roles of polyphenol-induced activities at a molecular level is important for the prevention and treatment of BPH. Polyphenols are composed of many members, and their biological roles differ. In this review, we first provide information regarding the pathological roles of oxidative stress and inflammation in BPH. Next, the antioxidant and anti-inflammatory effects of polyphenols, including those of flavonoids and non-flavonoids, are discussed. Finally, we talk about the results and limitations of previous clinical trials that have used polyphenols in BPH, with particular focus on their molecular mechanisms of action.

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The Polyphenols as Potential Agents in Prevention and Therapy of Prostate Diseases

Cited by 23 publications

References 217 publications

Beneficial Effects of Phenolic Compounds on Gut Microbiota and Metabolic Syndrome

Beneficial Effects of Phenolic Compounds on Gut Microbiota and Metabolic Syndrome

Polyphenols in cancer prevention: New insights (Review)

Pharmacological Effects and Potential Clinical Usefulness of Polyphenols in Benign Prostatic Hyperplasia

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