Pharmacological Effects and Potential Clinical Usefulness of Polyphenols in Benign Prostatic Hyperplasia

Abstract

Benign prostatic hyperplasia (BPH) is arguably the most common benign disease among men. This disease is often associated with lower urinary tract symptoms (LUTS) in men and significantly decreases the quality of life. Polyphenol consumption reportedly plays an important role in the prevention of many diseases, including BPH. In recent years, in addition to disease prevention, many studies have reported the efficacy and safety of polyphenol treatment against various pathological conditions in vivo and in vitro. Furthermore, numerous studies have also revealed the molecular mechanisms of the antioxidant and anti-inflammatory effects of polyphenols. We believe that an improved understanding of the detailed pharmacological roles of polyphenol-induced activities at a molecular level is important for the prevention and treatment of BPH. Polyphenols are composed of many members, and their biological roles differ. In this review, we first provide information regarding the pathological roles of oxidative stress and inflammation in BPH. Next, the antioxidant and anti-inflammatory effects of polyphenols, including those of flavonoids and non-flavonoids, are discussed. Finally, we talk about the results and limitations of previous clinical trials that have used polyphenols in BPH, with particular focus on their molecular mechanisms of action.

Bioactive Compounds from Pale Ale Beer Powder Attenuate Experimental Colitis in BALB/c Mice

“…Several natural PCs have been known to exert beneficial effects against various diseases, in addition to their intrinsic antioxidant and scavenging properties [35,36]. Currently, the rationale for the potential protective effects of PCs is based not only on their antioxidant actions but also on other anti-inflammatory and immunomodulatory properties [37,38]. Therefore, this study aimed to investigate the possible effects of PCs on other well-established mechanisms involved in DSS-induced colitis.…”

Evaluation of phytotherapy in Plantago major and Solanum aculeastrum vs a-blocker treatment of benign prostate hyperplasia by using ipss, clinic and ultrasound in Goma

“…In our study, we used the only questionnaire recommended by WHO based on the AUA-Is score [33] , namely the IPSS-QoL score. We only used dual therapy according to the local traditional practice and did not find the opportunity to combine our herbal medicine with conventional molecules like Vita Nunes R et al in Brazil who did so with Serenoa repens + tamsulosin or Serenoa repens + selenium + lycopene [38] nor to the polyphytherapy applied in Korea, China, India, Japan, or even in Côte d'Ivoire [39,40,41,42,43,44] . Also in Brazil, Calogero AE et al [45] recommended the combination of αblocker and a 5-Phosho-diesterase inhibitor (5-IPDE) through counseling.…”

The Etiology and Pathophysiology Genesis of Benign Prostatic Hyperplasia and Prostate Cancer: A New Perspective

“…Nutraceuticals supplement: three supplement combinations [231][232][233][234][235][236][237][238][239][240] are necessary to ameliorate the biological processes of endothelial dysfunction (e.g., l-citrulline [241][242][243], l-arginine [244,245]), oxidative stress and inflammation [246]; publications on this topic are extensive and therefore it is not discussed here.…”