The polyphenolics in the aqueous extract of<i>Psidium guajava</i>kinetically reveal an inhibition model on LDL glycation

Chen, Kuan Chou; Chuang, Chao Ming; Li, Lin; Chiu, Wen Ta; Wang, Hui Er; Hsieh, Chiu Lan; Tsai, Tsui Min; Peng, Robert Y.

doi:10.3109/13880200903029365

Cited by 21 publications

(15 citation statements)

References 26 publications

(34 reference statements)

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“…The homogenate was centrifuged at 1600 g for 10 min at 4°C and the supernatant collected. The remaining procedures were as reported by Chen et al . The OD was read at 530–540 nm.…”

Section: Methodsmentioning

confidence: 99%

“…The method of Chen et al 21 was used to determine MDA levels. Briefly, 1 mL RIPA buffer containing protease inhibitors was added to 100 mg pecking muscles obtained from HH Stage 46 (Day 1) chicks and the mixture homogenized.…”

Section: Malondialdehyde In Musculus Longissimus Cervicimentioning

confidence: 99%

“…The homogenate was centrifuged at 1600 g for 10 min at 4°C and the supernatant collected. The remaining procedures were as reported by Chen et al 21 The OD was read at 530-540 nm. A calibration curve was established using standard MDA from which the amount of MDA in pecking muscles was determined.…”

Section: Malondialdehyde In Musculus Longissimus Cervicimentioning

confidence: 99%

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Resveratrol and vitamin E rescue valproic acid‐induced teratogenicity: The mechanism of action

Hsieh

Chen

Lin

et al. 2014

Clin Exp Pharma Physio

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1. Valproic acid (VPA) induces haemorrhagic liposis of the cervical muscles in the chicken embryo model (CEM). Vitamin E and resveratrol (RV) exhibit prominent anti-oxidative and glutathione (GSH)-protecting effects. 2. In the present study we hypothesized that vitamin E and RV would ameliorate VPA induced haemorrhagic liposis in chick embryos. To this end, 120 Day 0 fertilized eggs were divided into 10 groups (n = 12 in each). The effects of different combinations of VPA (60 mmol/L), RV (0.2 and 2.0 mmol/L) and vitamin E (0.2 and 2.0 mmol/L) applied to Hamburger and Hamilton (HH) Stage 10 (Day 1.5) embryos were tested in the CEM using established methods. 3. Both RV and vitamin E (both at 2.0 mmol/L) effectively rescued neural tube defects in the early stage CEM and inhibited the malformation rate compared with that in the control group (8.4% and 5.0% vs 36.5 ± 3.0%, respectively; P < 0.05) and suppressed serum homocysteine and S-adenosylhomocysteine concentrations, downregulated cervical muscular carnitine, triglycerides, H2 O2 , malondialdehyde, interleukin-6 and ACC expression (P < 0.05 for all) and upregulated CPT1 expression and GSH (P < 0.05 for both). 4. The haemorrhagic liposis of cervical muscles can be alleviated by RV and vitamin E. It appears that the main mechanism of action of RV and vitamin E in rescuing VPA-induced teratogenicity is through the suppression of reactive oxygen species and upregulation of GSH.

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“…The homogenate was centrifuged at 1600 g for 10 min at 4°C and the supernatant collected. The remaining procedures were as reported by Chen et al . The OD was read at 530–540 nm.…”

Section: Methodsmentioning

confidence: 99%

Section: Malondialdehyde In Musculus Longissimus Cervicimentioning

confidence: 99%

See 1 more Smart Citation

Resveratrol and vitamin E rescue valproic acid‐induced teratogenicity: The mechanism of action

Hsieh

Chen

Lin

et al. 2014

Clin Exp Pharma Physio

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“…Gallic acid is a naturally occurring polyphenolic antioxidant and has been reported to be present in a number of plants such as Emblica officinalis [13], Camellia oleifera [14], Acacia confusa Merr [15], Crocus sativus [16], Psidium guajava [17], Allium cepa [18], olive oil [19], etc. Gallic acid derivatives have been shown to have neuroprotective and antioxidant activities [20].…”

Section: Introductionmentioning

confidence: 99%

Antidepressant‐like activity of gallic acid in mice subjected to unpredictable chronic mild stress

Chhillar

Dhingra²

2012

Fundamemntal Clinical Pharma

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This study was designed to evaluate antidepressant-like activity of gallic acid in Swiss young male albino mice subjected to unpredictable chronic mild stress and to explore the possible underlying mechanisms for this activity. Gallic acid (5, 10, 20 mg/kg, i.p.) and fluoxetine (10 mg/kg, i.p.) per se were administered daily to unstressed mice and other groups of mice subjected to unpredictable mild stress, 30 min after the injection for 21 successive days. The antidepressant-like activity was evaluated using forced swim test (FST) and sucrose preference test. Stress significantly increased immobility period of mice in FST. Gallic acid (10 and 20 mg/kg, i.p.) and fluoxetine significantly decreased immobility period of unstressed and stressed mice in FST and prevented the stress-induced decrease in sucrose preference, indicating significant antidepressant-like activity. There was no significant effect on locomotor activity of the mice by the drugs. Gallic acid (10 and 20 mg/kg, i.p.) significantly decreased Monoamine oxidase-A (MAO-A) activity, malondialdehyde levels, and catalase activity in unstressed mice; and significantly prevented the stress-induced decrease in reduced glutathione and catalase activity; and also significantly prevented stress-induced increase in MAO-A activity, malondialdehyde levels, plasma nitrite, and corticosterone levels. Thus, gallic acid showed antidepressant-like activity in unstressed and stressed mice probably due to its antioxidant activity and through inhibition of MAO-A activity and decrease in plasma nitrite levels. In addition, gallic acid also showed antidepressant-like activity in stressed mice probably through decrease in plasma corticosterone levels.

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“…It is low in calories and fats but carries several antioxidant polyphenolic and flavonoid compounds that play a crucial role in the prevention of many important diseases like prostate, colon, and epidermal cancers, as well as leukemia (Manosroi et al, 2005;Chen et al, 2007;Gutiérrez et al, 2008;Chen et al, 2010;and Ryu et al, 2012), aging, infections, etc. The wood is moderately strong and durable indoors; it is used for handles and in carpentry and turnery, and also for building timbers, wood ware and carvings.…”

Section: Introductionmentioning

confidence: 99%

Micropropagation of guava (Psidium guajava L.)

Hassanen¹,

Daib²,

Omar³

2017

IOSR JAVS

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The polyphenolics in the aqueous extract ofPsidium guajavakinetically reveal an inhibition model on LDL glycation

Abstract: (2010) The polyphenolics in the aqueous extract of Psidiumguajava kinetically reveal an inhibition model on LDL glycation, Pharmaceutical Biology, 48:1, 23-31,

Cited by 21 publications

References 26 publications

Resveratrol and vitamin E rescue valproic acid‐induced teratogenicity: The mechanism of action

Resveratrol and vitamin E rescue valproic acid‐induced teratogenicity: The mechanism of action

Antidepressant‐like activity of gallic acid in mice subjected to unpredictable chronic mild stress

Micropropagation of guava (Psidium guajava L.)

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