2022
DOI: 10.1007/s00192-021-04917-5
| View full text |Cite
|
Sign up to set email alerts
|

Abstract: Introduction and hypothesis Extracellular matrix (ECM) synthesis and metabolism abnormalities may influence the pelvic supporting system and lead to the occurrence and development of pelvic organ prolapse (POP). Genetic polymorphisms of such related genes have been increasingly studied. This study aims to explore the association between the single-nucleotide polymorphisms (SNPs) of genes encoding ECM processing enzymes (a disintegrin and metalloproteinase with thrombospondin motifs [ADAMTSs]), EC… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2

Citation Types

0
2
0

Year Published

2023
2023
2024
2024

Publication Types

Select...
4

Relationship

0
4

Authors

Journals

citations
Cited by 4 publications
(2 citation statements)
references
References 33 publications
0
2
0
Order By: Relevance
“…In addition, the steady state of ECM is an important factor for maintaining the normal distribution of pelvic organs. [14] In this study, upregulated genes in the POP group were found to be mainly enriched in CCs such as collagen-containing extracellular matrix, external encapsulating structure, and extracellular matrix.…”
Section: Discussionmentioning
confidence: 68%
“…In addition, the steady state of ECM is an important factor for maintaining the normal distribution of pelvic organs. [14] In this study, upregulated genes in the POP group were found to be mainly enriched in CCs such as collagen-containing extracellular matrix, external encapsulating structure, and extracellular matrix.…”
Section: Discussionmentioning
confidence: 68%
“…The abnormality of its synthesis and metabolism affects the whole pelvic floor system, leading to the occurrence of POP. [ 19 ] ECM is formed by Collagen, elastin, glycoproteins, and proteoglycans. [ 20 ] Collagens, including Collagen I and III, provide tensile strength and integrity to the pelvic floor.…”
Section: Discussionmentioning
confidence: 99%