The polymorphism of dopamine receptor D4 (DRD4) and dopamine transporter (DAT) genes in the men with antisocial behaviour and mixed martial arts fighters

Черепкова, Е. В.; Maksimov, V. N.; Kushnarev, Alexandr P; Шахматов, И И; Aftanas, Lyubomir I.

doi:10.1080/15622975.2017.1366056

Cited by 14 publications

(10 citation statements)

References 24 publications

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“…The research focus of the 18 studies can be divided into three groups: athletic performance (10) [ 6 – 16 ], pain perception (1) [ 17 ], and psychological traits including emotional or mental trait (6) [ 18 – 23 ] in combat sports athletes ( Table 1 ). Most of them were case-control studies, and one uniquely obtained samples from three groups for the polymorphism of dopamine receptor D4 (DRD4) and dopamine transporter (DAT) genes, including mixed martial arts (MMA) fighters as the reference group and a general population as the control group, and those who committed crimes, exhibiting antisocial behaviours, as the other comparison group ( Table 1 ) [ 20 ].…”

Section: Resultsmentioning

confidence: 99%

“…Catechol-O-methyltransferase ( COMT ) rs4680 was investigated in 3 studies [ 17 – 19 ], of which one reported an association in martial art fighters [ 18 ]. Regarding angiotensin-converting enzyme ( ACE ) rs4646994, μ-opioid receptor ( OPRM1 rs1799971), and dopamine D4 receptor gene ( DRD4 Ex3 VNTR), two studies were analysed per polymorphoism [ 7 , 12 , 17 - 21 ]; two studies did not demonstrate that one specific gene alone was associated with combat sports [ 7 , 20 ]. Moreover, a recent study presented 4 candidate polymorphisms using whole genome sequencing (WGS) in wrestlers [ 23 ].…”

Section: Resultsmentioning

confidence: 99%

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Genetic basis of elite combat sports athletes: a systematic review

Youn¹,

Kim

2021

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Each athlete’s innate talent is widely recognized as one of the important contributors to achievement in athletic performance, and genetic factors determine a significant portion of talent or traits. Advances in DNA sequencing technology allow us to discover specific genetic variants contributing to these traits in sports performance. The objective of this systematic review is to identify genes that may play a significant role in the performance of elite-level combat sports athletes. Through the review of 18 full-text articles, a total of 109 different polymorphisms were investigated in 14,313 participants (2,786 combat sports athletes, 8,969 non-athlete controls, 2,558 other sports athletes). Thirteen polymorphisms showed a significant difference between elite combat athletes and the control group, and consist of 8 (PPARA rs4253778, ACTN3 rs1815739, ACE rs4646994, CKM rs8111989, MCT1 rs1049434, FTO rs9939609, GABP β 1 rs7181866 and rs8031031) oriented to athletic performance and 5 (COMT rs4680, FEV rs860573, SLC6A2 rs2242446, HTR1B rs11568817, ADRA2A rs521674) focused on psychological traits including emotional and mental traits in combat sports athletes. In addition, a recent whole genome sequencing study identified 4 polymorphisms (KIF27 rs10125715, APC rs518013, TMEM229A rs7783359, LRRN3 rs80054135) associated with reaction time in wrestlers. However, it is not clearly identified which genes are linked explicitly with elite combat sports athletes and how they affect the elite athlete’s status or performance in combat sports. Hence, a greater number of candidate genes should be included in future studies to practically utilize the genetic information.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Genetic basis of elite combat sports athletes: a systematic review

Youn¹,

Kim

2021

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“…Since there exist polymorphisms in different position, exemplary in NHLH2 or MAO-A, the most important in relation to physical activity are the changes in other dopaminergic system components, including, among others, D2-D5 receptors, which are the main concern of this article [21,22]. There are various elements engaged in the process; however, we decided to concentrate on the most significant in relation to physical effort adaptations.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Selected Variants of DRD2 and ANKK1 Genes in Combat Athletes

Michałowska–Sawczyn

Chmielowiec

et al. 2021

Genes

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The level of physical activity is conditioned by many different factors, including, among others, the personality traits of a person. Important is the fact that personality traits are a moderately heritable factor and on the basis of the analysis of several genes, various lifetime outcomes can be predicted. One of the most important pathways influencing personality traits is connected to the dopaminergic system; hence, we decided to analyze the DRD2 PROM. rs1799732, DRD2 rs1076560, DRD2 Tag1D rs1800498, DRD2 Ex8 rs6276, DRD2Tag1B rs1079597 and ANKK1 Tag1A rs180049. The research group included 258 male athletes (mean age = 26.02; SD = 8.30), whereas the control group was 284 healthy male volunteers matched for age (mean age = 22.89; SD = 4.78), both of Caucasian origin and without history of substance dependency or psychosis. Genomic DNA was extracted from venous blood using standard procedures. Genotyping was conducted with the real-time PCR method. Differences in the frequency of the DRD2Tag1B rs1079597 gene polymorphism were found between people practicing combat sports and the control group, and the DRD2 PROM. rs1799732, DRD2 rs1076560, DRD2 Tag1D rs1800498, DRD2 Ex8 rs6276, DRD2Tag1B rs1079597 and ANKK1 Tag1A rs1800497 genotypes and allele frequencies in the studied sample did not differ between the analyzed groups. Hence, we considered these polymorphic places as an interesting area for the further search for unambiguous associations between personality traits and attitude towards physical effort.

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“…In another study, Boutwell et al found that persons with few DRD4 allele repetitions were less likely to be involved in criminal behavior, meaning that DRD4 had a positive association with non-abstention in delinquency [ 61 ]. Cherepkova et al reported a higher frequency of DRD4 7-repeat allele in criminal offenders and in mixed martial arts fighters without criminal record [ 62 ].…”

Section: Discussionmentioning

confidence: 99%

Forensic Value of Genetic Variants Associated with Anti-Social Behavior

et al. 2021

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Insanity defense is sometimes invoked in criminal cases, and its demonstration is usually based on a multifactorial contribution of behavioural, clinical, and neurological elements. Neuroradiological evidence of structural alterations in cerebral areas that involve decision-making and moral reasoning is often accepted as a useful tool in these evaluations. On the other hand, the genetic predisposition to anti-social behavior is still controversial. In this paper, we describe two cases of violent crimes committed by young carriers of genetic variants associated with personality disorder; both the defendants claimed to be insane at the time of the crime. We discuss these cases and review the scientific literature regarding the relationship between legal incapacity/predisposition to criminal behavior and genetic mutations. In conclusion, despite some genetic variants being able to influence several cognitive processes (like moral judgement and impulse control), there is currently no evidence that carriers of these mutations are, per se, incapable of intentionally committing crimes.

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The polymorphism of dopamine receptor D4 (DRD4) and dopamine transporter (DAT) genes in the men with antisocial behaviour and mixed martial arts fighters

Abstract: Our study supports the hypothesis of genetic predisposition to different variants of extreme behaviour mediated by genetic determinants involved in the functioning of neuromediator systems including those controlling dopamine pathways.

Cited by 14 publications

References 24 publications

Genetic basis of elite combat sports athletes: a systematic review

Genetic basis of elite combat sports athletes: a systematic review

Analysis of Selected Variants of DRD2 and ANKK1 Genes in Combat Athletes

Forensic Value of Genetic Variants Associated with Anti-Social Behavior

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