The polar-lipid composition of the sphingolipid-producing bacterium Flectobacillus major

Batrakov, S. G.; Mosezhnyi, Anatolii E.; Ruzhitsky, A. O.; Шейченко, В. И.; Никитин, Д. И.

doi:10.1016/s1388-1981(00)00011-1

Cited by 24 publications

(19 citation statements)

References 53 publications

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“…However, based on the data presented here and that currently available in the literature, it appears that a number of trends allow the delineation of the group, and further differentiation within the group. In particular, among the major phospholipids, ethanolamine phosphate head-groups seem to predominate and amino-acid-based lipids have also been reported in this group (Batrakov et al, 1998(Batrakov et al, , 1999(Batrakov et al, , 2000Kawazoe et al, 1991;Pitta et al, 1989). In addition to some of the common features in the polar lipid patterns, it should be noted that, of the few strains examined, the presence or absence of phosphatidylcholine or phosphatidylinositol may be significant (Batrakov et al, 1998(Batrakov et al, , 1999(Batrakov et al, , 2000Godchaux & Leadbetter, 1980, 1984Kawazoe et al, 1991;Le Bach & White, 1969;Naka et al, 2003;Pitta et al, 1989;Rizza et al, 1970).…”

mentioning

confidence: 80%

Petrimonas sulfuriphila gen. nov., sp. nov., a mesophilic fermentative bacterium isolated from a biodegraded oil reservoir

Grabowski

Tindall

Bardin

et al. 2005

International Journal of Systematic and Evolutionary Microbiology

291

103

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A mesophilic, anaerobic, fermentative bacterium, strain BN3T, was isolated from a producing well of a biodegraded oil reservoir in Canada. Cells were Gram-negative, non-motile rods that did not form spores. The temperature range for growth was 15–40 °C, with optimum growth at 37–40 °C. The strain grew with up 4 % NaCl, with optimum growth in the absence of NaCl. Tryptone was required for growth. Yeast extract and elemental sulfur stimulated growth. Growth was also enhanced during fermentation of glucose, arabinose, galactose, maltose, mannose, rhamnose, lactose, ribose, fructose, sucrose, cellobiose, lactate, mannitol and glycerol. Acetate, hydrogen and CO2were produced during glucose fermentation. Elemental sulfur and nitrate were used as electron acceptors and were reduced to sulfide and ammonium, respectively. The G+C content of the genomic DNA was 40·8 mol%. Phylogenetic analyses of the 16S rRNA gene sequence indicated that the strain was a member of the phylum ‘Bacteroidetes’, distantly related to the generaBacteroidesandTannerella(similarity values of less than 90 %). The chemotaxonomic data (fatty acids, polar lipids and quinones composition) also indicated that strain BN3Tcould be clearly distinguished from its closest cultivated relatives. This novel organism possesses phenotypic, chemotaxonomic and phylogenetic traits that do not allow its classification as a member of any previously described genus; therefore, it is proposed that this isolate should be described as a member of a novel species of a new genus,Petrimonasgen. nov., of whichPetrimonas sulfuriphilasp. nov. is the type species. The type strain is BN3T(=DSM 16547T=JCM 12565T).

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mentioning

confidence: 80%

Petrimonas sulfuriphila gen. nov., sp. nov., a mesophilic fermentative bacterium isolated from a biodegraded oil reservoir

Grabowski

Tindall

Bardin

et al. 2005

International Journal of Systematic and Evolutionary Microbiology

291

103

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“…The older literature on this topic is mainly concerned with lipoamino acids of bacterial origin (Batrakov et al, 2000;Kawai et al, 1990;Kawazoe et al, 1991;Lerouge et al, 1988;Miyazaki et al, 1993). These involve amino acid conjugation with complex and unusual fatty acids and little is known about their function in bacteria.…”

Section: Lipoamino Acids (Fatty Acid-amino Acid Conjugates): General mentioning

confidence: 99%

The elmiric acids: Biologically active anandamide analogs

Burstein

2008

Neuropharmacology

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SummaryAs chemical entities, lipoamino acids have been known for some time. However, more recently their occurrence and importance in mammalian species has been discovered. They appear to have close relationships with the endocannabinoids not only structurally but also in terms of biological actions. The latter include analgesia, anti-inflammatory effects, inhibition of cell proliferation and calcium ion mobilization. To date about 40 naturally occurring members of this family have been identified and, additionally, several synthetic analogs have been prepared and studied. To facilitate their identity, a nomenclature system has been suggested based on the name elmiric acid (EMA). The prototypic example, N-arachidonoyl glycine does not bind to CB1, however it does inhibit the glycine transporter GLYT2a and also appears to be a ligand for the orphan G-protein-coupled receptor GPR18. It may also have a role in regulating tissue levels of anandamide by virtue of its inhibitory effect on FAAH the enzyme that mediates inactivation of anandamide. Its concentration in rat brain is several fold higher than anandamide supporting its possible role as a physiological mediator. Future studies should be aimed at elucidating the actions of all of the members of this interesting family of molecules. Keywordsendocannabinoid; lipoamino acid; eicosanoid; elmiric acid; inflammation; anandamide Lipoamino acids (fatty acid-amino acid conjugates): general considerationsThe older literature on this topic is mainly concerned with lipoamino acids of bacterial origin (Batrakov et al., 2000;Kawai et al., 1990;Kawazoe et al., 1991;Lerouge et al., 1988;Miyazaki et al., 1993). These involve amino acid conjugation with complex and unusual fatty acids and little is known about their function in bacteria.More recently, attention has been given to lipoamino acids present in mammalian species in part because of their possible relationships to the endocannabinoids. The closely related analog of anandamide, N-arachidonylglycine (NAGly), is in a sense, a comparable acid analog to anandamide as the THC metabolite, THC-11-oic acid is to THC. NAGly is an endogenous substance found in rat brain and other sites that occurs in amounts greater than the closely related endocannabinoid, anandamide (Huang et al., 2001). However, the origin of NAGly in vivo is not completely understood. Sumner.Burstein@umassmed.edu, Tel: 508-856-2850, Fax: 508-856-2003. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Prior reports (Burstein et al. 1997;Huang et al., 2001), suggest that NAGly might have analgesic properties similar to tho...

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“…Monomethyl branched-chain FAs (mmBCFAs) in ISO configuration as well as in anteISO configuration (methyl group appended on the second to the terminal carbon) also seem to be ubiquitous in nature. They are present in particularly large quantities in various bacterial genera, including cold-tolerating and thermophilic species (Merkel and Perry 1977; Annous et al 1997; Ferreira et al 1997; Batrakov et al 2000; Jahnke et al 2001; Groth et al 2002; Nichols et al 2002). There, mmBCFAs contribute to the membrane function, regulating fluidity (Rilfors et al 1978; Suutari and Laakso 1994; Cropp et al 2000; Jones et al 2002) and proton permeability (van de Vossenberg et al 1999).…”

Section: Introductionmentioning

confidence: 99%

Monomethyl Branched-Chain Fatty Acids Play an Essential Role in Caenorhabditis elegans Development

et al. 2004

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Monomethyl branched-chain fatty acids (mmBCFAs) are commonly found in many organisms from bacteria to mammals. In humans, they have been detected in skin, brain, blood, and cancer cells. Despite a broad distribution, mmBCFAs remain exotic in eukaryotes, where their origin and physiological roles are not understood. Here we report our study of the function and regulation of mmBCFAs in Caenorhabditis elegans, combining genetics, gas chromatography, and DNA microarray analysis. We show that C. elegans synthesizes mmBCFAs de novo and utilizes the long-chain fatty acid elongation enzymes ELO-5 and ELO-6 to produce two mmBCFAs, C15ISO and C17ISO. These mmBCFAs are essential for C. elegans growth and development, as suppression of their biosynthesis results in a growth arrest at the first larval stage. The arrest is reversible and can be overcome by feeding the arrested animals with mmBCFA supplements. We show not only that the levels of C15ISO and C17ISO affect the expression of several genes, but also that the activities of some of these genes affect biosynthesis of mmBCFAs, suggesting a potential feedback regulation. One of the genes, lpd-1, encodes a homolog of a mammalian sterol regulatory element-binding protein (SREBP 1c). We present results suggesting that elo-5 and elo-6 may be transcriptional targets of LPD-1. This study exposes unexpected and crucial physiological functions of C15ISO and C17ISO in C. elegans and suggests a potentially important role for mmBCFAs in other eukaryotes.

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The polar-lipid composition of the sphingolipid-producing bacterium Flectobacillus major

Cited by 24 publications

References 53 publications

Petrimonas sulfuriphila gen. nov., sp. nov., a mesophilic fermentative bacterium isolated from a biodegraded oil reservoir

Petrimonas sulfuriphila gen. nov., sp. nov., a mesophilic fermentative bacterium isolated from a biodegraded oil reservoir

The elmiric acids: Biologically active anandamide analogs

Monomethyl Branched-Chain Fatty Acids Play an Essential Role in Caenorhabditis elegans Development

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