The pleiotropic allatoregulatory neuropeptides and their receptors: A mini-review

Verlinden, Heleen; Gijbels, M. J. M.; Lismont, Els; Lenaerts, Cynthia; Broeck, Jozef Vanden; Marchal, Elisabeth

doi:10.1016/j.jinsphys.2015.04.004

Cited by 75 publications

(69 citation statements)

References 154 publications

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“…Allatostatins (ASTs), as their name suggests, were originally identified as neuropeptides that inhibit the biosynthesis of juvenile hormone (JH) in the corpora allata of insects [reviewed by 17]. Three structurally distinct subfamilies of neuropeptides (A-, B- and C-type ASTs), were identified that share this function [17]. However, the name ‘allatostatin’ can be misleading, as the allatostatic properties of these neuropeptides are not shared across all insect groups [17].…”

Section: Introductionmentioning

confidence: 99%

“…Three structurally distinct subfamilies of neuropeptides (A-, B- and C-type ASTs), were identified that share this function [17]. However, the name ‘allatostatin’ can be misleading, as the allatostatic properties of these neuropeptides are not shared across all insect groups [17]. Many putative ASTs, including the honey bee ( Apis mellifera ) neuropeptides examined in this study, have been identified based on sequence similarity rather than biological activity.…”

Section: Introductionmentioning

confidence: 99%

“…Many putative ASTs, including the honey bee ( Apis mellifera ) neuropeptides examined in this study, have been identified based on sequence similarity rather than biological activity. At least 5 neuropeptides categorized as A-type allatostatins are expressed in the brain of the bee [18–20], all of which share the Y/FXFGL-NH2 consensus sequence characteristic of this subfamily [17,21]. The most abundant A-type AST in the brain, and the form examined in this study, is ASTA4 (GRQPYSFGL-amide) [18].…”

Section: Introductionmentioning

confidence: 99%

“…While both receptors were originally identified based on their similarity to opioid receptors, insect ASTA receptors are most closely related to galanin receptors in vertebrates, whereas ASTC receptors are more closely related to vertebrate somatostatin receptors [14–17]. Opioids, somatostatin and galanin are among many neuropeptides in the vertebrate brain that not only influence learning and memory [23], but participate also in stress physiology [24–25].…”

Section: Introductionmentioning

confidence: 99%

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C-type allatostatins mimic stress-related effects of alarm pheromone on honey bee learning and memory recall

2017

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As honey bee populations worldwide are declining there is an urgent need for a deeper understanding of stress reactivity in these important insects. Our data indicate that stress responses in bees (Apis mellifera L.) may be mediated by neuropeptides identified, on the basis of sequence similarities, as allatostatins (ASTA, ASTC and ASTCC). Effects of allatostatin injection are compared with stress-related changes in learning performance induced by the honeybee alarm pheromone, isopentylacetate (IPA). We find that bees can exhibit two markedly different responses to IPA, with opposing effects on learning behaviour and memory generalisation, and that strikingly similar responses can be elicited by allatostatins, in particular ASTCC. These findings lend support to the hypothesis that allatostatins mediate stress reactivity in honey bees and suggest responses to stress in these insects are state dependent.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

C-type allatostatins mimic stress-related effects of alarm pheromone on honey bee learning and memory recall

2017

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“…Allatostatins (ASTs) constitute a group of neuropeptides that has been originally characterized because of their inhibitory effect on the synthesis of JHs in insects. A member of this group of neuropeptides, Allatostatin-C (AST-C), originally characterized in Manduca sexta (Lepidoptera, Insecta), displays myoregulatory functions in several insect species (for a review see [6,42]). …”

Section: -Introductionmentioning

confidence: 99%

Somatostatin signaling system as an ancestral mechanism: Myoregulatory activity of an Allatostatin-C peptide in Hydra

2016

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Neuropeptides as potential modulators of behavioral transitions in the ant Cataglyphis nodus

Habenstein

Thamm

Rößler

2021

J of Comparative Neurology

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Age‐related behavioral plasticity is a major prerequisite for the ecological success of insect societies. Although ecological aspects of behavioral flexibility have been targeted in many studies, the underlying intrinsic mechanisms controlling the diverse changes in behavior along the individual life history of social insects are not completely understood. Recently, the neuropeptides allatostatin‐A, corazonin, and tachykinin have been associated with the regulation of behavioral transitions in social insects. Here, we investigated changes in brain localization and expression of these neuropeptides following major behavioral transitions in Cataglyphis nodus ants. Our immunohistochemical analyses in the brain revealed that the overall branching pattern of neurons immunoreactive (ir) for the three neuropeptides is largely independent of the behavioral stages. Numerous allatostatin‐A‐ and tachykinin‐ir neurons innervate primary sensory neuropils and high‐order integration centers of the brain. In contrast, the number of corazonergic neurons is restricted to only four neurons per brain hemisphere with cell bodies located in the pars lateralis and axons extending to the medial protocerebrum and the retrocerebral complex. Most interestingly, the cell‐body volumes of these neurons are significantly increased in foragers compared to freshly eclosed ants and interior workers. Quantification of mRNA expression levels revealed a stage‐related change in the expression of allatostatin‐A and corazonin mRNA in the brain. Given the presence of the neuropeptides in major control centers of the brain and the neurohemal organs, these mRNA‐changes strongly suggest an important modulatory role of both neuropeptides in the behavioral maturation of Cataglyphis ants.

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The pleiotropic allatoregulatory neuropeptides and their receptors: A mini-review

Cited by 75 publications

References 154 publications

C-type allatostatins mimic stress-related effects of alarm pheromone on honey bee learning and memory recall

C-type allatostatins mimic stress-related effects of alarm pheromone on honey bee learning and memory recall

Somatostatin signaling system as an ancestral mechanism: Myoregulatory activity of an Allatostatin-C peptide in Hydra

Neuropeptides as potential modulators of behavioral transitions in the ant Cataglyphis nodus

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