C-type allatostatins mimic stress-related effects of alarm pheromone on honey bee learning and memory recall

Urlacher, Elodie; Devaud, Jean-Marc; Mercer, Alison R.

doi:10.1371/journal.pone.0174321

Cited by 16 publications

(11 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Exposure to both the sting alarm pheromone and to IAA alone impairs appetitive olfactory PER conditioning in a dose-dependent manner, but leaves sucrose responsiveness intact 35 . Learning impairment is mediated probably by allatostatins, in particular by the C-type allatostatin (ASTCC), which might be therefore responsible for the stress-induced analgesia 44 . If and how allatostatins interact with aminergic pathways to modulate learning and memory remains to be determined.…”

Section: Discussionmentioning

confidence: 99%

Pheromone components affect motivation and induce persistent modulation of associative learning and memory in honey bees

et al. 2020

Self Cite

View full text Add to dashboard Cite

Since their discovery in insects, pheromones are considered as ubiquitous and stereotyped chemical messengers acting in intraspecific animal communication. Here we studied the effect of pheromones in a different context as we investigated their capacity to induce persistent modulations of associative learning and memory. We used honey bees, Apis mellifera , and combined olfactory conditioning and pheromone preexposure with disruption of neural activity and two-photon imaging of olfactory brain circuits, to characterize the effect of pheromones on olfactory learning and memory. Geraniol, an attractive pheromone component, and 2-heptanone, an aversive pheromone, improved and impaired, respectively, olfactory learning and memory via a durable modulation of appetitive motivation, which left odor processing unaffected. Consistently, interfering with aminergic circuits mediating appetitive motivation rescued or diminished the cognitive effects induced by pheromone components. We thus show that these chemical messengers act as important modulators of motivational processes and influence thereby animal cognition.

show abstract

Section: Discussionmentioning

confidence: 99%

Pheromone components affect motivation and induce persistent modulation of associative learning and memory in honey bees

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…In situ hybridisation shows that Spot/vp-like mRNA, similar to mollusk op/ct, is distributed in various kinds of neurons in cerebral ganglion, such as 6th and 7th neuronal clusters involved in reproductive regulation, and 8th and 9th in olfaction, learning and memory regulation [45][46][47]. Spot/vpr-like mRNA is expressed in F-cells of hepatopancreas, the main sites of enzyme synthesis, suggesting that the system may participate in the regulation of hepatopancreas on digestion, metabolism and reproduction.…”

Section: Discussionmentioning

confidence: 99%

Role of Oxytocin/Vasopressin-Like Peptide and Its Receptor in Vitellogenesis of Mud Crab

Lin

Wei

2020

IJMS

View full text Add to dashboard Cite

Oxytocin (OT)/vasopressin (VP) signaling system is important to the regulation of metabolism, osmoregulation, social behaviours, learning, and memory, while the regulatory mechanism on ovarian development is still unclear in invertebrates. In this study, Spot/vp-like and its receptor (Spot/vpr-like) were identified in the mud crab Scylla paramamosain. Spot/vp-like transcripts were mainly expressed in the nervous tissues, midgut, gill, hepatopancreas, and ovary, while Spot/vpr-like were widespread in various tissues including the hepatopancreas, ovary, and hemocytes. In situ hybridisation revealed that Spot/vp-like mRNA was mainly detected in 6–9th clusters in the cerebral ganglion, and oocytes and follicular cells in the ovary, while Spot/vpr-like was found to localise in F-cells in the hepatopancreas and oocytes in the ovary. In vitro experiment showed that the mRNA expression level of Spvg in the hepatopancreas, Spvgr in the ovary, and 17β-estradiol (E2) content in culture medium were significantly declined with the administration of synthetic SpOT/VP-like peptide. Besides, after the injection of SpOT/VP-like peptide, it led to the significantly reduced expression of Spvg in the hepatopancreas and subduced E2 content in the haemolymph in the crabs. In brief, SpOT/VP signaling system might inhibit vitellogenesis through neuroendocrine and autocrine/paracrine modes, which may be realised by inhibiting the release of E2.

show abstract

“…A notable exception is in the Diptera, including both Drosophila melanogaster ( Kreienkamp et al 2002 ) and the mosquito Aedes aegypti ( Mayoral et al 2010 ), where two AST-C receptors have been identified ( Kreienkamp et al 2002 ; Mayoral et al 2010 ). Nonetheless, in those insects in which the functional effects of multiple AST-Cs have been examined ( Audsley et al 2013 ; Dong et al 2017 ; Urlacher et al 2016 , 2017 ), it has been suggested that the peptides act on the single receptor that was identified, although potentially with different affinities (e.g., Urlacher et al 2016 ). Interestingly, in one of the few crustaceans in which neuropeptide receptors have been predicted, H. americanus , three different AST-C receptors were recently identified using a transcriptome derived from mixed nervous system tissues ( Christie et al 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Three members of a peptide family are differentially distributed and elicit differential state-dependent responses in a pattern generator-effector system

Dickinson

Armstrong

Fernandez

et al. 2018

Journal of Neurophysiology

View full text Add to dashboard Cite

C-type allatostatins (AST-Cs) are pleiotropic neuropeptides that are broadly conserved within arthropods; the presence of three AST-C isoforms, encoded by paralog genes, is common. However, these peptides are hypothesized to act through a single receptor, thereby exerting similar bioactivities within each species. We investigated this hypothesis in the American lobster, Homarus americanus, mapping the distributions of AST-C isoforms within relevant regions of the nervous system and digestive tract, and comparing their modulatory influences on the cardiac neuromuscular system. Immunohistochemistry showed that in the pericardial organ, a neuroendocrine release site, AST-C I and/or III and AST-C II are contained within distinct populations of release terminals. Moreover, AST-C I/III-like immunoreactivity was seen in midgut epithelial endocrine cells and the cardiac ganglion (CG), whereas AST-C II-like immunoreactivity was not seen in these tissues. These data suggest that AST-C I and/or III can modulate the CG both locally and hormonally; AST-C II likely acts on the CG solely as a hormonal modulator. Physiological studies demonstrated that all three AST-C isoforms can exert differential effects, including both increases and decreases, on contraction amplitude and frequency when perfused through the heart. However, in contrast to many state-dependent modulatory changes, the changes in contraction amplitude and frequency elicited by the AST-Cs were not functions of the baseline parameters. The responses to AST-C I and III, neither of which is COOH-terminally amidated, are more similar to one another than they are to the responses elicited by AST-C II, which is COOH-terminally amidated. These results suggest that the three AST-C isoforms are differentially distributed in the lobster nervous system/midgut and can elicit distinct behaviors from the cardiac neuromuscular system, with particular structural features, e.g., COOH-terminal amidation, likely important in determining the effects of the peptides.NEW & NOTEWORTHY Multiple isoforms of many peptides exert similar effects on neural circuits. In this study we show that each of the three isoforms of C-type allatostatin (AST-C) can exert differential effects, including both increases and decreases in contraction amplitude and frequency, on the lobster cardiac neuromuscular system. The distribution of effects elicited by the nonamidated isoforms AST-C I and III are more similar to one another than to the effects of the amidated AST-C II.

show abstract

C-type allatostatins mimic stress-related effects of alarm pheromone on honey bee learning and memory recall

Cited by 16 publications

References 64 publications

Pheromone components affect motivation and induce persistent modulation of associative learning and memory in honey bees

Pheromone components affect motivation and induce persistent modulation of associative learning and memory in honey bees

Role of Oxytocin/Vasopressin-Like Peptide and Its Receptor in Vitellogenesis of Mud Crab

Three members of a peptide family are differentially distributed and elicit differential state-dependent responses in a pattern generator-effector system

Contact Info

Product

Resources

About