The platelet to lymphocyte ratio is a potential inflammatory marker predicting the effects of adjuvant chemotherapy in patients with stage II colorectal cancer

Yu, Fu Shun; Chen, Xiaowan; Song, Yongxi; Huang, Xiaoxian; Chen, Quan; Lv, Xinger; Gao, Peng; Wang, Zhenning

doi:10.1186/s12885-021-08521-0

Cited by 12 publications

(15 citation statements)

References 60 publications

(80 reference statements)

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“…analyzed 708 stage II CRC patients. They found that chemotherapy patients with high PLR had significantly longer overall survival and cancer-specific survival than non-chemotherapy patients ( 30 ). However, Davari et al.…”

Section: Discussionmentioning

confidence: 99%

“…Conversely, NVI was associated with the poor prognosis of stage III patients. overall survival and cancer-specific survival than non-chemotherapy patients (30). However, Davari et al also analyzed 184 locally recurrent rectal cancer patients and found that NLR >3.9 and PLR >275 were related to a lower 5-yr overall survival (31).…”

Section: The Platelet-lymphocyte-ratio (Plr) Is Closely Related To Thementioning

confidence: 99%

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Prognostic role of preoperative inflammatory markers in postoperative patients with colorectal cancer

et al. 2023

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BackgroundInflammatory response markers are prognostic factors for several cancers, but their role in postoperative colorectal cancer (CRC) is unclear. The purpose was to evaluate the role of preoperative Neutrophil-to-Lymphocyte ratio (NLR), Platelet-to-Lymphocyte-ratio (PLR), and Lymphocyte-to-Monocyte ratio (LMR) in the prognosis of postoperative CRC patients.MethodsWe retrospectively reviewed 448 CRC patients who had undergone surgical resection from December 2015 to December 2017 in our hospital. The plasma NLR, PLR, LMR, CEA, and CA19-9 were collected within 2 weeks before the operation. We recorded the clinical characteristics and survival data by reviewing medical records and phone calls. We analyzed preoperative inflammatory markers and clinical features using Pearson chi-squared tests or Fisher’s tests. Uni- and multivariate Cox regression analyses were performed, and overall survival (OS) was estimated with the Kaplan–Meier method.ResultsHigh NLR and PLR were associated with worse overall survival in postoperative CRC (HR = 2.140, 95%CI = (1.488-3.078), P < 0.001; HR =1.820, 95%CI = (1.271-2.605), P = 0.001). High LMR was associated with improved overall survival in postoperative CRC (HR = 0.341, 95%CI = (0.188-0.618), P < 0.001). In the multivariate regression analysis, the increase of NLR resulted in an increase in the risk of death (HR = 1.678, 95%CI = (1.114-2.527), P = 0.013), and for the LMR, a reduction of the risk of death (HR = 0.480, 95%CI = (0.256 - 0.902), P = 0.023). Moreover, TNM stage, CA-199, CEA, nerve or vascular invasion (NVI) and adjuvant chemotherapy after surgery also were associated with worse overall survival in postoperative CRC.ConclusionCurrent evidence indicates that preoperative inflammatory markers NLR, LMR, and PLR are associated with overall survival in postoperative patients with colorectal cancer. NLR is an independent risk factor, and LMR is an independent protective factor in CRC patients after surgery.

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Section: Discussionmentioning

confidence: 99%

Section: The Platelet-lymphocyte-ratio (Plr) Is Closely Related To Thementioning

confidence: 99%

Prognostic role of preoperative inflammatory markers in postoperative patients with colorectal cancer

et al. 2023

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“…PLR can be used to assess the dynamic balance between anti-tumor immunity in vivo. When PLR is high, there is an immune imbalance between anti-tumor and tumor-promoting ( 23 ). Catal’s team research shows that PLT supports the formation of blood vessels in tumor tissues, the growth and diffusion of cancer cells and subsequent secondary lesions; PLR is related to the size and degree of tumor invasion ( 24 ).…”

Section: Discussionmentioning

confidence: 99%

Expression and Predictive Value of Serum NLR, PLR Combined with SAA in Patients with Different Stages of Colorectal Cancer

Yang¹,

Sun

Zhao

2022

Front. Surg.

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Colorectal cancer (CRC) is one of the major causes of death in the world, and has become a serious threat to human life. The prognosis of CRC patients in different pathological stages is quite different, so it is necessary to evaluate the clinical stages of CRC patients before surgery. Neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), serum amyloid A (SAA) and other indicators have been widely proved to play the role of early diagnosis and prognosis monitoring in chronic inflammatory diseases and cancers. In this study, we collected clinical data of 103 patients with CRC confirmed by pathology in Yiwu Central Hospital from January 2019 to December 2021. In addition, it aims to explore the expression and predictive value of NLR, PLR combined with SAA in patients with different stages of CRC, so as to provide reference for patients to choose a reasonable treatment plan. The results show that serum NLR, PLR combined with SAA can predict CRC staging effectively, which has certain auxiliary value for clinical decision-making.

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“…It's reported that colorectal cancer patients with a high level of PLR respond better to chemotherapy [22].…”

Section: Discussionmentioning

confidence: 99%

Platelet-lymphocyte ratio predicts chemotherapy response and prognosis in patients with gastric cancer undergoing radical resection

Zeng

Wang

wang

et al. 2022

Preprint

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Introduction Amounting literatures have reported the significance of systemic inflammatory markers for evaluating tumor prognosis. But few studies have systematically compared their superiority and their impact on adjuvant chemotherapy. Materials and Methods We retrospectively enrolled 730 GC patients who underwent radical gastrectomy. Fibrinogen (FIB), platelet-lymphocyte ratio (PLR), systemic inflammation response index (SIRI), prognostic nutritional index (PNI), systemic immune-inflammation index (SII), neutrophil-lymphocyte ratio (NLR) and lymph node ratio (LNR) were grouped according to cutoff values. Their clinical significance for GC prognosis was determined by multivariate COX regression analysis in both overall and subgroups by PLR status. Cases were divided into four groups according to PLR status and adjuvant chemotherapy status and survival was compared between groups. Results Multivariate analysis showed that PLR was an independent prognostic factor for overall survival (OS) and disease-free survival (DFS) of GC patients. Adjuvant chemotherapy improved survival more significantly in patients with low PLR than that with high PLR. Among patients receiving adjuvant chemotherapy, low PLR was significantly associated with prolonged survival in TNM stage II, but not in TNM stage III. Conclusion Preoperative high PLR is an independent risk factor for GC patients undergoing radical gastrectomy and adversely affects the postoperative chemotherapy effect.

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The platelet to lymphocyte ratio is a potential inflammatory marker predicting the effects of adjuvant chemotherapy in patients with stage II colorectal cancer

Cited by 12 publications

References 60 publications

Prognostic role of preoperative inflammatory markers in postoperative patients with colorectal cancer

Prognostic role of preoperative inflammatory markers in postoperative patients with colorectal cancer

Expression and Predictive Value of Serum NLR, PLR Combined with SAA in Patients with Different Stages of Colorectal Cancer

Platelet-lymphocyte ratio predicts chemotherapy response and prognosis in patients with gastric cancer undergoing radical resection

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