Introduction Advanced lung cancer inflammation index (ALI) has been implicated in the prognosis of many types of tumors. But few studies elucidate its role in gastric cancer (GC). Materials and methods We consecutively recruited 615 GC patients who underwent radical gastrectomy. Patients were grouped according to ALI status. Risk factors for overall survival (OS) and disease-free survival (DFS) in overall and sex-stratified cohorts were determined using multivariate cox regression analysis. We also compared survival differences between the two groups after one-to-one propensity score matching (PSM). Results Patients with low ALI showed larger tumor size, more advanced TNM staging, shorter OS (median: 37 vs 42 months) and DFS (median: 37 vs 42 months) (all P < 0.001). Multivariate analysis showed that elevated ALI was independently associated with longer OS and DFS. After stratification by sex, low ALI was an independent risk factor for OS and DFS in male patients but not in female patients. But our further PSM analysis showed prognostic value of ALI in both male and female subgroups. Conclusion Preoperative ALI is an independent prognostic factor for GC patients undergoing curative gastrectomy.
This study aims to explore the prognostic variables for elderly papillary thyroid microcarcinoma (PTMC) patients as well as create a nomogram that could predict the occurrence of cervical lymph node metastasis (CLNM) on the basis of a large population database with high quality. A total of 5165 PTMC patients from Surveillance, Epidemiology, and End Results database database were enrolled in the study. In the meantime, we retrospectively collected 205 PTMC patients who underwent thyroidectomy in our medical center as an external control to test the accuracy of the model. The independent predictors of survival were identified by multivariate Cox regression analysis. Risk factors were selected as nomogram parameters to develop a model to predict CLNM. The C-index and calibration plots were used to evaluate CLNM model discrimination. The predictive nomogram was further validated in the external validation set. 76.8% of the enrolled patients underwent thyroidectomy. Overall survival and cancer-specific survival were significantly better in patients who underwent surgery than in those who did not ( P < .001). Sex, tumor size, and extent of tumor were included in a multivariable logistic regression model to predict lymph node metastasis. The nomogram had good discrimination with a C-index of 0.71. The calibration curves showed perfect agreement between nomogram predictions and actual observations. Elderly PTMC patients who received a surgical approach without radiotherapy showed survival advantage than those with other treatment strategies. Moreover, a nomogram model was established to predict the risk of CLNM, which will help clinicians in making treatment decisions.
Introduction Amounting literatures have reported the significance of systemic inflammatory markers for evaluating tumor prognosis. But few studies have systematically compared their superiority and their impact on adjuvant chemotherapy. Materials and Methods We retrospectively enrolled 730 GC patients who underwent radical gastrectomy. Fibrinogen (FIB), platelet-lymphocyte ratio (PLR), systemic inflammation response index (SIRI), prognostic nutritional index (PNI), systemic immune-inflammation index (SII), neutrophil-lymphocyte ratio (NLR) and lymph node ratio (LNR) were grouped according to cutoff values. Their clinical significance for GC prognosis was determined by multivariate COX regression analysis in both overall and subgroups by PLR status. Cases were divided into four groups according to PLR status and adjuvant chemotherapy status and survival was compared between groups. Results Multivariate analysis showed that PLR was an independent prognostic factor for overall survival (OS) and disease-free survival (DFS) of GC patients. Adjuvant chemotherapy improved survival more significantly in patients with low PLR than that with high PLR. Among patients receiving adjuvant chemotherapy, low PLR was significantly associated with prolonged survival in TNM stage II, but not in TNM stage III. Conclusion Preoperative high PLR is an independent risk factor for GC patients undergoing radical gastrectomy and adversely affects the postoperative chemotherapy effect.
Background The down-regulation of LHPP has been reported as a tumor suppressor gene in several malignancies. This study aims to explore the potential roles of LHPP across 33 types of tumors. Methods The TCGA database was mainly used to investigate the correlation of LHPP expression pattern with clinical prognosis and other function related gene sets. Additionally, immunohistochemistry and western blot assay were used to detect the expression level of LHPP in tissue samples for stomach adenocarcinoma (STAD) patients. We next established STAD cell lines with exogenous silencing/ overexpression of LHPP. qRT-PCR, western blot assay, CCK-8 assay and colony formation assays were performed for cell function identifications. Results LHPP was widely down-regulated in tumor tissues compared with normal tissues in pan-cancer across 13 cancer types. The expression level of LHPP was associated with favorable survival across diverse cancers. Moreover, we observed that LHPP expression was significantly correlated with immune infiltration, tumor mutation burden (TMB), microsatellite instability (MSI), mismatch repair genes (MMRs), and DNA methyltransferases in many tumors. Validation in clinical tissue samples confirmed LHPP was down-regulated in STAD. Functional experiments demonstrated that LHPP suppressed cell proliferation of STAD via down-regulating p‑PI3K/p‑AKT expression levels. Conclusion Our first pan-cancer study provided insight into the role of LHPP in tumorigenesis. Besides, LHPP may acts as a tumor suppressor gene in STAD.
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