The platelet indices in pediatric patients with acute appendicitis

Yılmaz, Yakup; Kara, Fatih; Gümüşdere, Musa; Arslan, Hasan Hüseyin; Üstebay, Sefer

doi:10.18203/2320-6012.ijrms20150153

Cited by 9 publications

(13 citation statements)

References 17 publications

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“…Yılmaz et al reported that PCT has no supportive value in the diagnosis of AA. 13 Kostakis et al reported interesting findings in their study, with no significant differences detected between the patients and healthy controls in respect of the platelet count, MPV, and PDW. 12 In particular, a lower PCT in female adult patients with AA was determined but not as a sufficient diagnostic index of this disease.…”

Section: Discussionmentioning

confidence: 77%

“…While there are many studies that have mainly focused on mean platelet volume (MPV), there are very few studies on other platelet indicators including PDW and PCT, especially in the pediatric age group. [2][3][4][5][6][7][8][9][10][11][12][13] PDW is an indicator of platelet volume variability in size, indicating morphological changes and platelet reactivity. The activation of platelets causes morphological changes that increase PDW.…”

Section: Discussionmentioning

confidence: 99%

“…While some of these studies have demonstrated a correlation between PDW and AA, others have reported no change in the value of PDW. 2,[7][8][9][10][11][12][13][14] Many of these studies have been conducted on adults, and only one has studied children. Dinc at al first reported that PDW may be a supportive parameter in the diagnosis of AA.…”

Section: Discussionmentioning

confidence: 99%

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Is There a Supporting Value of Platelet Distribution Width and Plateletcrit in the Diagnosis of Acute Appendicitis in Children?

Bilici

Öztaş

Dursun

2019

J Pediatr Infect Dis

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This study was designed to investigate the diagnostic value of platelet distribution width (PDW) and plateletcrit (PCT) for acute appendicitis in childhood. A retrospective review was conducted of the records of 373 patients younger than 18 years who underwent appendectomy. Demographic data, white blood cell count, neutrophil count, and PDW and PCT values were recorded for all patients. A control group was formed of age- and gender-matched healthy children. The study results showed that the PDW level is not valuable as a marker for the diagnosis of acute appendicitis in children. PCT levels were determined to be statistically significantly increased in pediatric acute appendicitis with low specificity.

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Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

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Is There a Supporting Value of Platelet Distribution Width and Plateletcrit in the Diagnosis of Acute Appendicitis in Children?

Bilici

Öztaş

Dursun

2019

J Pediatr Infect Dis

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“…Since a decrease was observed in all CBC parameters (including Hb, Hct, platelets and lymphocytes), we concluded that these values tended to decrease secondary to hemodilution. Normovolemic hemodilution with crystalloid or colloid solutions based on a calculation of blood loss during surgery is a method that has been applied for many years (21,22). A relative decrease in blood cell components due to a hemodilution-related increase in blood plasma volume is not surprising.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Complete Blood Count Parameters Before and After Appendectomy

Katipoğlu¹,

Evrın²,

Yaman³

2019

eamr

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Objective: Acute appendicitis (AA) is the most common cause of intra-abdominal surgery worldwide and its diagnosis continues to be problematic despite advanced technology and diagnostic methods. Easily accessible, economical and non-invasive tests are still under investigation for the diagnosis and after surgery. The purpose of this study was to review postoperative changes in patients' complete blood count (CBC) parameters. Methods:The research was performed as a single-center, retrospective, cross-sectional study. After obtaining the approval of the ethics committee, the data obtained from patients aged over 18, who underwent appendectomy between January 1, 2015 and November 30, 2017, and who were diagnosed with histopathologically confirmed AA, were retrospectively examined. Wilcoxon test was used in statistical analysis to compare pre-and post-operative changes in CBC parameters. A p value of less than 0.05 was considered statistically significant.Results: Men constituted 50% (n=726) of the 1452 enrolled patients. The mean age of the patients was 32.3±16.1 years. Statistically significant differences were determined between pre-operative and post-operative leukocyte white blood cell, lymphocyte, hemoglobin, hematocrit, plateletcrit and mean platelet volume values. Mean neutrophil and platelet count values decreased in the post-operative period, although these decreases were not statistically significant. No statistically significant difference was determined between pre-operative and post-operative neutrophil/lymphocyte ratio (NLR) values. Conclusion:Dilutional changes in CBC parameters may occur following fluid therapy in the post-operative period. We also conclude that NLR is not affected by fluid treatment and may be a valuable parameter in monitoring post-appendectomy infection.

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“…23,24 There are studies which found similar results and opposite results with our study. [23][24][25] It is known that WBC values are frequently elevated in patients with acute appendicitis. 23,26 In our study, WBC count was significantly higher in the acute appendicitis group.…”

Section: Discussionmentioning

confidence: 99%

Relationship Between Acute Appendicitis and Platelet Indices in Childhood

Sucu¹,

Tolunay²,

Cesur³

et al. 2018

cayd

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Introduction:Appendicitis is the inflammation of the appendix vermiformis. Clinical diagnosis of acute appendicitis in children is still a problem. Platelet indices, platelet distribution width and mean platelet volume have been evaluated for some infectious and inflammatory diseases. In this study, we aimed to investigate whether platelet distribution width values and mean platelet volume were decisive for the diagnosis of appendicitis in children. Methods: In our hospital, 504 pediatric patients who presented with acute abdomen and received the diagnosis of acute appendicitis between 2011 and 2016, and 106 children living in the same region, who attended the pediatric outpatient clinics for general followup, were included in the study. The patient and control groups were analyzed for gender, age, platelet count, platelet distribution width and mean platelet volume. A receiver operating characteristic (ROC) curve was drawn to describe the parameters that may be statistically significant. Results: There was a significant difference in platelet distribution width and mean platelet volume values between the two groups (p<0.001). The platelet distribution width values were higher and the mean platelet volume values were lower in appendicitis patients than in healthy children. The ROC curve analysis suggested a cut-off value of >14.3 fL for platelet distribution width for the diagnosis of appendicitis with a sensitivity, specificity, positive predictive value, and negative predictive value of 77.6%, 85.8%, 96.3%, and 44.6%, respectively. A cut-off value of <9.35 fL for mean platelet volume was used for the diagnosis of appendicitis with a sensitivity, specificity, positive predictive value, and negative predictive value of 78.1%, 81.1%, 95.2%, and 43.9%, respectively. Conclusion: Our results suggest that platelet distribution width and mean platelet volume may be used for the diagnosis of appendicitis in children with the sensitivity of at least 77.6% and 78.1%, respectively. Mean platelet volume and platelet distribution width, which can easily be investigated in complete blood count, may serve as markers for the diagnosis of appendicitis in children, however, further large-scale studies are needed. Keywords: Appendicitis, mean platelet volume, platelet indices, platelet distribution width Giriş: Apandisit appendiks vermiformisin iltihaplanmasıdır. Akut apandisitin klinik tanısı çocuklarda hala bir problemdir. Trombosit indeksleri, ortalama trombosit dağılım genişliği ve trombosit hacmi, bazı enfeksiyöz ve enflamatuvar hastalıklar için değerlendirilmiştir. Bu çalışmada, çocuklarda apandisit tanısı için ortalama trombosit dağılım genişliği ve trombosit hacmi değerlerinin belirleyici olup olmadığını araştırmayı amaçladık. Yöntemler: Hastanemizde, 2011-2016 yılları arasında akut karın nedeniyle akut apandisit tanısı alan 504 çocuk ve aynı bölgede yaşayan sağlam çocuk polikliniğine genel takip için başvuran 106 çocuk çalışmaya alındı. Hasta ve kontrol grupları cinsiyet, yaş, trombosit sayısı, ortalama trombosit dağılım...

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The platelet indices in pediatric patients with acute appendicitis

Cited by 9 publications

References 17 publications

Is There a Supporting Value of Platelet Distribution Width and Plateletcrit in the Diagnosis of Acute Appendicitis in Children?

Is There a Supporting Value of Platelet Distribution Width and Plateletcrit in the Diagnosis of Acute Appendicitis in Children?

Evaluation of Complete Blood Count Parameters Before and After Appendectomy

Relationship Between Acute Appendicitis and Platelet Indices in Childhood

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