The Plasma Pattern of Ovarian Steroids during the Menstrual Cycle in Capuchin Monkeys (Cebus apella)

Nagle, Carlos A.; Denari, J. H.; Quiroga, S.; Riarte, Adelina; Merlo, Alicia; Germino, N. I.; Gómez-Argaña, Francisca; Rosner, Jorge M.

doi:10.1095/biolreprod21.4.979

Cited by 31 publications

(23 citation statements)

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“…The changes in the serum concentrations of E 2 and P, and the relationships between follicular growth/ovulation and vaginal cytology and hormonal parameters were similar to those reported by Nagle et al [1979] and Nagle and Denari [1983], who used laparoscopy to visualize the ovaries. In their studies and the current one, the presence of a large number of superficial eosinophilic cells in the vaginal smear coincided with the presence of a preovulatory follicle and high levels of E 2 , while a reduced number of eosinophilic cells associated with leukocytes and intermediate cells coincided with the presence of a CL and/or high levels of progesterone ( Fig.…”

Section: Discussionsupporting

confidence: 84%

“…3a and b). We found higher concentrations of P in the mid-luteal phase than previously reported [Nagle et al, 1979;Nagle & Denari, 1983]. The difference may reflect the use of different RIA protocols and/or antibodies in the different studies [Nagle et al, 1979].…”

Section: Discussioncontrasting

confidence: 53%

“…The New World monkey Cebus apella (capuchin monkey) is being used successfully to advance our knowledge about the reproductive processes of primates. Most of the available information on the physiology of the menstrual cycle in this species is derived from reports by Nagle et al [1979Nagle et al [ , 1980 and Nagle and Denari [1983]. These authors described the vaginal cytology and temporal relationships between the plasma profile of a luteinizing hormone (LH)-like activity, estradiol (E 2 ) and progesterone (P), and ovulation determined by radioimmunoassay (RIA) and serial laparoscopy, respectively.…”

Section: Introductionmentioning

confidence: 99%

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Cytologic, hormonal, and ultrasonographic correlates of the menstrual cycle of the New World monkey Cebus apella

Ortíz

Ortiz

Gajardo

et al. 2005

American J Primatol

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Few reports on the reproductive physiology of Cebus apella have been published. In this study we characterized menstrual cycle events by means of vaginal cytology, ultrasonography (US), and hormonal measurements in serum during three consecutive cycles in 10 females, and assessed the probability that ovulation would occur in the same ovary in consecutive cycles in 18 females. The lengths and phases of the cycles were determined according to vaginal cytology. Taking the first day of endometrial bleeding as the first day of the cycle, the mean cycle length +/- SEM was 19.5+/-0.4 days, with follicular and luteal phases lasting 8.2+/-0.2 and 11.3+/-0.4 days, respectively. The follicular phase included menstruation and the periovulatory period, which was characterized by the presence of a large number of superficial eosinophilic cells in the vaginal smear. The myometrium, endometrium, and ovaries were clearly distinguished on US examination. During each menstrual cycle a single follicle was recruited at random from either ovary. The follicle grew from 3 mm to a maximum diameter of 8-9 mm over the course of 8 days, in association with increasing estradiol (E(2)) serum levels (from 489+/-41 to 1600+/-92 pmol/L). At ovulation, the mean diameter of the dominant follicle usually decreased by >20%, 1 day after the maximum E(2) level was reached. Ovulation was associated with an abrupt fall in E(2), a decreased number of eosinophilic cells, the presence of leukocytes and intermediate cells in the vaginal smear, and a progressive increase in progesterone (P) levels that reached a maximum of 892+/-65 nmol/L on days 3-6 of the luteal phase. The menstrual cycle of Cebus apella differs in several temporal and quantitative aspects from that in humans and Old World primates, but it exhibits the same correlations between ovarian endocrine and morphologic parameters.

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Section: Discussionsupporting

confidence: 84%

Section: Discussioncontrasting

confidence: 53%

Section: Introductionmentioning

confidence: 99%

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Cytologic, hormonal, and ultrasonographic correlates of the menstrual cycle of the New World monkey Cebus apella

Ortíz

Ortiz

Gajardo

et al. 2005

American J Primatol

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“…Ovulation in robust capuchins has been shown to occur on the same day as the rise in urinary progesterone (Nagle et al, 1979). In addition, the rise in fecal progesterone metabolites occurs within 0 to 24 h of the urinary progestogen rise (Carosi et al, 1999).…”

Section: Fecal Sample Collection Hormone Analysis and Assessment Ofmentioning

confidence: 99%

Female behavioral proceptivity functions as a probabilistic signal of fertility, not female quality, in a New World primate

Tiddi

Wheeler

Heistermann

2015

Hormones and Behavior

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The interests of males and females in mating contexts often conflict, and identifying the information conveyed by sexual signals is central to understanding how signalers manage such conflicts. Research into the information provided by female primate sexual signals has focused on exaggerated anogenital swellings as either reliable-indicators of reproductive quality (reliable-indicator hypothesis) or probabilistic signals of fertility (graded-signal hypothesis). While these morphological signals are mostly confined to catarrhine primates, these hypotheses are potentially widely applicable across primates, but have not been tested in taxa that lack such morphological signals. Here, we tested these hypotheses in wild black capuchins (Sapajus nigritus), a species in which females lack morphological sexual signals but produce conspicuous behavioral estrous displays. Specifically, we examined the proportion of time different females spent producing these signals with respect to measures of female quality (dominance rank, parity, age-related fecundity and cycle type) and in relation to the timing of fertility, as determined by analysis of fecal progesterone. Time spent displaying did not vary across females based on measures of female quality, but increased with the approach of ovulation. Further, male mating effort varied according to the timing of female fertility. Proceptive behaviors in this species thus meet predictions of the graded-signal hypothesis, providing the first support for this hypothesis based solely on behavioral signals.

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“…The New World monkey Cebus apella, also called the capuchin monkey, is a suitable model for research in human reproduction (16)(17)(18). Follicular development monitored by ultrasound or laparoscopy shows close similarities with women, and egg retrieval can be achieved from follicles ranging between 2 and 9 mm (19)(20).…”

mentioning

confidence: 99%

Effects of follicular phase and oocyte–cumulus complexes quality on the protein profile and in vitro oocyte meiosis competence in Cebus apella

Domingues

Caldas-Bussiere

Petretski

et al. 2010

Fertility and Sterility

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The Plasma Pattern of Ovarian Steroids during the Menstrual Cycle in Capuchin Monkeys (Cebus apella)

Cited by 31 publications

References 0 publications

Cytologic, hormonal, and ultrasonographic correlates of the menstrual cycle of the New World monkey Cebus apella

Cytologic, hormonal, and ultrasonographic correlates of the menstrual cycle of the New World monkey Cebus apella

Female behavioral proceptivity functions as a probabilistic signal of fertility, not female quality, in a New World primate

Effects of follicular phase and oocyte–cumulus complexes quality on the protein profile and in vitro oocyte meiosis competence in Cebus apella

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