The plasma membrane redox system in aging

Hyun, Dong Hoon; Hernandez, Joe O.; Mattson, Mark P.; Cabo, Rafael de

doi:10.1016/j.arr.2006.03.005

Cited by 131 publications

(91 citation statements)

References 117 publications

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“…Another possibility is that the up-regulation of the PRMS is secondary to a primary effect of CR on energy metabolism. Indeed, it was recently reported that CR results in an increase in the expression of the mitochondrial uncoupling protein UCP4, resulting in decreased mitochondrial ATP and reactive oxygen species production (24), an effect of CR that would be expected to up-regulate the PMRS (46).…”

Section: Discussionmentioning

confidence: 99%

Calorie restriction up-regulates the plasma membrane redox system in brain cells and suppresses oxidative stress during aging

Hyun

Emerson

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

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The plasma membrane (PM) contains redox enzymes that provide electrons for energy metabolism and recycling of antioxidants such as coenzyme Q and ␣-tocopherol. Brain aging and neurodegenerative disorders involve impaired energy metabolism and oxidative damage, but the involvement of the PM redox system (PMRS) in these processes is unknown. Caloric restriction (CR), a manipulation that protects the brain against aging and disease, increased activities of PMRS enzymes (NADH-ascorbate free radical reductase, NADH-quinone oxidoreductase 1, NADH-ferrocyanide reductase, NADH-coenzyme Q10 reductase, and NADH-cytochrome c reductase) and antioxidant levels (␣-tocopherol and coenzyme Q10) in brain PM during aging. Age-related increases in PM lipid peroxidation, protein carbonyls, and nitrotyrosine were attenuated by CR, levels of PMRS enzyme activities were higher, and markers of oxidative stress were lower in cultured neuronal cells treated with CR serum compared with those treated with ad libitum serum. These findings suggest important roles for the PMRS in protecting brain cells against age-related increases in oxidative and metabolic stress.Alzheimer's disease ͉ reactive oxygen species ͉ coenzyme Q10 ͉ oxidoreductase

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Section: Discussionmentioning

confidence: 99%

Calorie restriction up-regulates the plasma membrane redox system in brain cells and suppresses oxidative stress during aging

Hyun

Emerson

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

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249

160

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“…CR, a robust anti‐aging intervention that extends lifespan in almost all organisms tested, is accompanied by the rescue of age‐associated decline of CYB5R3 and NQO1 function [reviewed in (de Cabo, Siendones, Minor & Navas, 2009; Hyun, Hernandez, Mattson & de Cabo, 2006)]. Likewise, several pharmacological and genetical‐based strategies targeting these enzymes have been employed to ultimately delay aging and age‐related metabolic diseases (Calabrese, Cornelius, Dinkova‐Kostova, Calabrese & Mattson, 2010; Lee et al., 2012; Martin‐Montalvo et al., 2016; Rizvi & Pandey, 2010; Varela‐Lopez, Giampieri, Battino & Quiles, 2016).…”

Section: Introductionmentioning

confidence: 99%

Overexpression of CYB5R3 and NQO1, two NAD⁺‐producing enzymes, mimics aspects of caloric restriction

et al. 2018

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SummaryCalorie restriction (CR) is one of the most robust means to improve health and survival in model organisms. CR imposes a metabolic program that leads to increased stress resistance and delayed onset of chronic diseases, including cancer. In rodents, CR induces the upregulation of two NADH‐dehydrogenases, namely NAD(P)H:quinone oxidoreductase 1 (Nqo1) and cytochrome b 5 reductase 3 (Cyb5r3), which provide electrons for energy metabolism. It has been proposed that this upregulation may be responsible for some of the beneficial effects of CR, and defects in their activity are linked to aging and several age‐associated diseases. However, it is unclear whether changes in metabolic homeostasis solely through upregulation of these NADH‐dehydrogenases have a positive impact on health and survival. We generated a mouse that overexpresses both metabolic enzymes leading to phenotypes that resemble aspects of CR including a modest increase in lifespan, greater physical performance, a decrease in chronic inflammation, and, importantly, protection against carcinogenesis, one of the main hallmarks of CR. Furthermore, these animals showed an enhancement of metabolic flexibility and a significant upregulation of the NAD +/sirtuin pathway. The results highlight the importance of these NAD + producers for the promotion of health and extended lifespan.

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“…ISSN: 2503-2364 Antioxidant Activity of Ethanolic Extract and Fraction of Salak Fruit Seeds (Salacca Zalacca (Gaertn. ) (Hyun, et al,2006;Kinnula & Crapo, 2004;Singh et al,2006;, Singh, et al, 2004;Smith, et al, 2000). (Adikristya, 2017).…”

Section: Abstrakmentioning

confidence: 99%

Antioxidant Activity of Ethanolic Extract and Fraction of Salak Fruit Seeds ( Salacca Zalacca (Gaertn.) Voss. ) Using DPPH (2,2-Diphenyl-1-Picrylhydrazyl) Method

Werdyani

Jumaryatno

Khasanah

2017

eksakta

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Salak seeds have been developed as a beverage, but there was still a little amount of research that focused on salak seeds. This research was conducted to find out the chemical compounds and the antioxidant activity of ethanolic extract and fraction of salak fruits seeds ( Salacca zalacca (Gaertn.) Voss. ) which have been grown extensively in Sleman Yogyakarta. Extraction was conducted using maceration, followed by fractionation using vacuum liquid chromatography. The identification of the chemical compounds contained in the ethanolic extract and fraction was performed by thin layer chromatography method, while the antioxidant activity was performed by DPPH method. Comparison of antioxidant activity was seen using IC 50 values. The results showed that ethanol extract and fraction contained phenol, flavonoid, and tannin. The largest antioxidant activity was found in F7 with an IC 50 value of 110.16 μg / ml. Keywords: Antioxidant, salak fruit seeds, DPPH ABSTRAKBiji buah salak telah banyak dikembangkan sebagai minuman kopi biji salak, namun penelitian mengenai kandungan serta manfaatnya belum banyak dilakukan. Penelitian ini bertujuan untuk mengetahui kandungan dan aktivitas antioksidan ekstrak etanol serta fraksi biji buah salak pondoh ( Salacca zalacca (Gaertn.) Voss. ) yang tumbuh di Sleman Yogyakarta. Ekstraksi dilakukan dengan metode maserasi yang dilanjutkan dengan fraksinasi menggunakan metode kromatografi cair vakum. Identifikasi senyawa yang terkandung dalam ekstrak dan fraksi kemudian dilakukan melalui metode kromatografi lapis tipis, sedangkan aktivitas antioksidan dilakukan dengan metode DPPH. Perbandingan aktivitas antioksidan dilihat menggunakan nilai IC 50 . Hasil penelitian menunjukkan bahwa ekstrak etanol dan fraksi mengandung fenol, flavonoid, dan tannin. Aktivitas antioksidan terbesar terdapat pada F7 dengan nilai IC 50 sebesar 110,16 µg/ml.

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The plasma membrane redox system in aging

Cited by 131 publications

References 117 publications

Calorie restriction up-regulates the plasma membrane redox system in brain cells and suppresses oxidative stress during aging

Calorie restriction up-regulates the plasma membrane redox system in brain cells and suppresses oxidative stress during aging

Overexpression of CYB5R3 and NQO1, two NAD⁺‐producing enzymes, mimics aspects of caloric restriction

Antioxidant Activity of Ethanolic Extract and Fraction of Salak Fruit Seeds ( Salacca Zalacca (Gaertn.) Voss. ) Using DPPH (2,2-Diphenyl-1-Picrylhydrazyl) Method

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The plasma membrane redox system in aging

Cited by 131 publications

References 117 publications

Calorie restriction up-regulates the plasma membrane redox system in brain cells and suppresses oxidative stress during aging

Calorie restriction up-regulates the plasma membrane redox system in brain cells and suppresses oxidative stress during aging

Overexpression of CYB5R3 and NQO1, two NAD+‐producing enzymes, mimics aspects of caloric restriction

Antioxidant Activity of Ethanolic Extract and Fraction of Salak Fruit Seeds ( Salacca Zalacca (Gaertn.) Voss. ) Using DPPH (2,2-Diphenyl-1-Picrylhydrazyl) Method

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Overexpression of CYB5R3 and NQO1, two NAD⁺‐producing enzymes, mimics aspects of caloric restriction