The plasma logarithm of the triglyceride/HDL-cholesterol ratio is a predictor of low risk gestational diabetes in early pregnancy

Santos-Weiss, Izabella Castilhos Ribeiro dos; Réa, Rosângela Roginski; Picheth, Geraldo; Rego, Fabiane Gomes de Moraes; Pedrosa, Fábio de Oliveira; Gillery, Philippe; Souza, Emanuel Maltempi de

doi:10.1016/j.cca.2012.12.004

Cited by 37 publications

(32 citation statements)

References 30 publications

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“…2;34;36 and none in Brazil, to our knowledge. There are several Brazilian publications that demonstrate associations between lipids and BMI, 37 depressive symptoms, 38 changes in pressure, 39 risk of gestational diabetes, 40 without, however, using cut-off points to determine the increase in morbidities or specific risks for dyslipidemia during pregnancy. The present study demonstrated that pregnant women with dyslipidemia defined by guideline criteria had higher TC and HDL and lower TG concentrations than pregnant women with dyslipidemia according to percentile criteria, suggesting that the guideline criterion selects cases of greater severity in relation to dyslipidemia .…”

Section: Discussionmentioning

confidence: 99%

Impact of the Use of Different Diagnostic Criteria in the Prevalence of Dyslipidemia in Pregnant Women

Feitosa¹,

Barreto²,

Silva³

et al. 2017

Arquivos Brasileiros De Cardiologia

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BackgroundThere is a physiologic elevation of total cholesterol (TC) and triglycerides (TG) during pregnancy. Some authors define dyslipidemia (DLP) in pregnant women when TC, LDL and TG concentrations are above the 95th percentile (p95%) and HDL concentration is below the 5th percentile (P5%) for gestational age (GA).ObjectiveTo compare the prevalence of DLP in pregnant women using percentiles criteria with the V Brazilian Guidelines on Dyslipidemia and the association with maternal and fetal outcomes.ResultsPregnant women with high-risk conditions, aged 18-50 years, and at least one lipid profile during pregnancy was classified as the presence of DLP by two diagnostic criteria. Clinical and laboratorial data of mothers and newborns were evaluated.Conclusion433 pregnant women aged 32.9 ± 6.5 years were studied. Most (54.6%) had lipid profile collected during third trimester. The prevalence of any lipid abnormalities according to the criteria of the National Guidelines was 83.8%: TC ≥ 200 mg/dL was found in 49.9%; LDL ≥ 160 mg/dL, in 14.3%, HDL ≤ 50 mg/dL in 44.4% and TG ≥ 150 mg/dL in 65.3%. Any changes of lipid according to percentiles criteria was found in 19.6%: elevation above the P95% for TC was found in 0.7%; for LDL, 1.7%; for TG 6.4% and HDL lower than the P5% in 13%. The frequency of comorbidity: hypertension, diabetes, smoking, obesity and preeclampsia was similar among pregnant women when DLP was compared by both criteria.ConclusionThe prevalence of DLP during pregnancy varies significantly depending on the criteria used, however none demonstrated superiority in association with comorbidities.

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Section: Discussionmentioning

confidence: 99%

Impact of the Use of Different Diagnostic Criteria in the Prevalence of Dyslipidemia in Pregnant Women

Feitosa¹,

Barreto²,

Silva³

et al. 2017

Arquivos Brasileiros De Cardiologia

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“…El primero tiene una sensibilidad del 82,6%, especificidad del 83,4% y valor predictivo negativo +Model del 97,8%, en gestaciones tempranas (12-24 semanas) para discriminar entre pacientes sanas de aquellas con riesgo de desarrollar diabetes gestacional 43 . El segundo combina la circunferencia abdominal con los triglicéridos 39 , y medido en el primer trimestre de la gestación está asociado con un incremento de la resistencia a la insulina al final del segundo trimestre 38 , por lo que podría utilizarse como un marcador precoz de mujeres con riesgo de desarrollar diabetes gestacional.…”

Section: Diabetes Gestacionalunclassified

Comportamiento de los lípidos durante la gestación y su relación con acontecimientos obstétricos desfavorables

Ferriols

Rueda

Gamero

et al. 2016

Clínica e Investigación en Arteriosclerosis

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Lipids play an important role during pregnancy, and in this period major changes occur in lipoprotein metabolism. During the third trimester plasma cholesterol and triglyceride levels are substantially increased, returning to normal after delivery. Described associations between increased morbidity during pregnancy and excessive increases in plasma cholesterol and triglycerides. For this reason we have reviewed the relationship between lipid alterations, preeclampsia, gestational diabetes and preterm birth. The overall metabolic control can improve pregnancy outcomes, and the assessment of supraphysiological changes in lipid profile will classify pregnancy risk at a higher level, which would entail a stricter control.

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“…Kod zdravih trudnica naše populacije ova vrednost ne prelazi 0,2 (9). Budući da su visoke vrednosti triglicerida povezane sa gestacijskim dijabetesom, a HDL-holesterol se ne menja značajno tokom trudnoće, čak i kod gestacijskog dijabetesa, smatra se da bi AIP mogao biti i dobar prediktor dijabetesa u trudnoći (14). Takođe je konstatovano da postoji značajna povezanost između visoke vrednosti odnosa LDL ̸ HDL-hol u ranoj trudnoći i prevremenog porođaja (15).…”

Section: Lipidni Indeksiunclassified

“…Za razliku od LDL lipoproteinskih čestica, distribucija HDL subklasa je manje istraživana. Zaštitna uloga HDL holesterola ne zavisi samo od koncentracije HDL-a, već i od 13,2 (11,(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)9) 15,3 (13,(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)9) funkcionalnog kvaliteta HDL čestica. Antiaterogeni efekat HDL holesterola objašnjava se njegovom funkcionalnom zaštitom, posredovanjem transporta holesterola iz perifernih tkiva u jetru, ali i njegovom antiinflamatornom i antioksidativnom ulogom (25).…”

Section: Remodeliranje Ldl I Hdl Lipoproteinskih čEstica Tokom Fiziolunclassified

Lipid status in phyisiological non-complicated pregnancy

Ardalić¹,

Stefanović²,

Spasić³

et al. 2016

Arh farmaciju

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Specifično izmenjen lipidni profil i fiziološka hiperlipidemija tokom trudnoće smatraju se esencijalnim za normalan ishod trudnoće i razvoj fetusa, a upravo ova specifičnost promena parametara lipidnog profila otvara pitanja njihove potencijalne proaterogenosti tokom trudnoće i uticaja na rizik za razvoj kardiovaskularne bolesti u kasnijem životu žene. Takođe se ispituje i povezanost izmenjenog lipidnog profila tokom trudnoće sa razvojem komplikacija u trudnoći, pre svega sa razvojem gestacijskog dijabetesa, hipertenzije i preeklampsije. Posredovanjem holesterol estar transportnog proteina (CETP), čija aktivnost raste sredinom trudnoće, dolazi do izmene triglicerida i holesterola između lipoproteinskih čestica vrlo niske gustine (VLDL) i lipoproteinskih čestica male gustine (LDL) ili lipoproteinskih čestica velike gustine (HDL), tako da dolazi do povećanog nakupljanja triglicerida u LDL i HDL česticama, pri čemu one postaju manje i gušće, i kao takve imaju veći proaterogeni potencijal, što sve ukazuje i na proaterogeni potencijal trudnoće, posebno ukoliko se ona ponavlja više puta tokom života. Da bi se optimizirao prediktivni kapacitet lipidnog profila tokom trudnoće preporučuje se određivanje lipidnih indeksa.

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The plasma logarithm of the triglyceride/HDL-cholesterol ratio is a predictor of low risk gestational diabetes in early pregnancy

Cited by 37 publications

References 30 publications

Impact of the Use of Different Diagnostic Criteria in the Prevalence of Dyslipidemia in Pregnant Women

Impact of the Use of Different Diagnostic Criteria in the Prevalence of Dyslipidemia in Pregnant Women

Comportamiento de los lípidos durante la gestación y su relación con acontecimientos obstétricos desfavorables

Lipid status in phyisiological non-complicated pregnancy

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