The Plasma Levels of the Angiogenic Cytokine Endocan Are Elevated in Patients with Multiple Myeloma

Steiner, Normann; Ševčı́ková, Sabina; Borjan, Bojana; Untergasser, Gerold; Göbel, Georg; Gunsilius, Eberhard

doi:10.21873/anticanres.12828

Cited by 6 publications

(5 citation statements)

References 14 publications

(18 reference statements)

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“…12,[16][17][18][19][20] High levels of endocan have also been detected at in many types of cancer, and it may show cancer activation and differentiate benign and malignant disease. [21][22][23][24] COVID-19 can be associated with micro and/or macro emboli and progresses with vascular inflammation. [25][26][27] In this context, our study was based on the hypothesis that endocan levels, which are a specific marker for vascular endothelial cells, will be elevated levels in patients with COVID-19.…”

Section: Discussionmentioning

confidence: 99%

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Diagnostic and Prognostic Value of Serum Endocan Levels in Patients With COVID-19

Görgün

Cindoruk

Özgen³

et al. 2021

Angiology

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We aimed to evaluate whether there was a relationship between endocan (human endothelial cell-specific molecule-1) levels and disease prognosis in patients who presented to the emergency department with coronavirus disease 2019 (COVID-19). A total of 60 patients with COVID-19 who were hospitalized from the emergency department to clinical wards and a control group consisting of healthy adult individuals (n = 28), were included in the study. The majority (93.3%) of the patients were discharged after recovery; 6.7% died. The median endocan value was 243.5 ng/mL in the patient group versus 201.5 ng/mL in the control group ( P = .002). The median endocan level was 240.5 ng/mL in those discharged with recovery and 558 ng/mL in those who died ( P = .001). There was no significant relationship in hospitalization duration, sex, tomography findings, and clinical outcomes. A 202 ng/mL serum endocan level had 86.7% sensitivity and 50% specificity for COVID-19. Serum endocan levels may be a useful biomarker both for the diagnosis of COVID-19 and to predict mortality.

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Section: Discussionmentioning

confidence: 99%

“…12,16–20 High levels of endocan have also been detected at in many types of cancer, and it may show cancer activation and differentiate benign and malignant disease. 21–24…”

Section: Discussionmentioning

confidence: 99%

Diagnostic and Prognostic Value of Serum Endocan Levels in Patients With COVID-19

Görgün

Cindoruk

Özgen³

et al. 2021

Angiology

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“…Moreover, endocan values have found to be significantly increased in sepsis, type 2 diabetes mellitus, systemic lupus erythematosus, renal insufficiency, oncologic diseases, Behçet disease, psoriasis vulgaris, and epilepsy in adults. [41][42][43][44][45][46][47][48][49] In pediatric populations, recent studies reported high serum endocan levels in patients with necrotizing enterocolitis and juvenile idiopathic arthritis in the neonatal period. 50,51 But to the best of our knowledge, there is no study in a pediatric population assessing the risk of atherosclerosis in obese patients using endocan and cIMT.…”

Section: Discussionmentioning

confidence: 99%

Increased Carotid Intima–Media Thickness and Endothelial Cell-Specific Molecule-1 (Endocan) Levels in Obese Children

et al. 2021

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Obesity in children appears to be associated with increased risk of cardiovascular and metabolic diseases later in life. Early development of insulin resistance (IR) may lead to endothelial dysfunction and increased carotid intima–media thickness (cIMT) even in childhood. We compared endothelial cell-specific molecule-1 (endocan) levels in pediatric obese patients with those in healthy controls to determine whether endocan could be used as a biological marker of complications caused by endothelial damage. In 80 obese pubertal children (44 males [M] and 36 females [F], mean age: 12.8 ± 2.5 years), anthropometric measurements, cIMT, endocan levels, and IR indices (homeostasis model assessment of insulin resistance [HOMA-IR]) were evaluated and compared with 80 healthy pubertal patients (42M/38F, mean age: 12.3 ± 3.2 years). High-resolution ultrasound was used to measure the cIMT. Obese children had higher levels of endocan compared with the controls ( P < .001). Fasting insulin levels and HOMA-IR were also higher in obese children ( P < .001 for both). In addition, obese children had an increased cIMT ( P < .001). In obese children, there was a significant correlation between cIMT and HOMA-IR (β = −1.314, P = .002) and between cIMT and endocan (β = .483, P = .004). Measuring cIMT and endocan levels (noninvasive investigations) in obese children, together with early preventive measures, could significantly decrease morbidity and mortality in adulthood.

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“…Clinical investigations have consistently confirmed the abnormal expression of ESM1 in the blood or tumor tissues of patients with diverse cancers. Notably, elevated ESM1 levels have been observed in the circulatory systems of patients diagnosed with endometrial, cervical, renal, breast and lung cancer, multiple myeloma and hepatocellular carcinoma (19,(86)(87)(88)(89)(90). Furthermore, upregulated ESM1 expression has been detected in tumor samples collected from patients with pancreatic neuroendocrine tumors and glioblastoma (91,92).…”

Section: Value Of Esm1 As a Prognostic And Predictive Indicator Of Ca...mentioning

confidence: 99%

Roles of endothelial cell specific molecule‑1 in tumor angiogenesis (Review)

Zhou,

Wang

et al. 2024

Oncol Lett

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Angiogenesis plays a crucial role in tumor growth and metastasis, and is heavily influenced by the tumor microenvironment (TME). Endothelial cell dysfunction is a key factor in tumor angiogenesis and is characterized by the aberrant expression of pro-angiogenic factors. Endothelial cell specific molecule-1 (ESM1), also known as endocan, is a marker of endothelial cell dysfunction. Although ESM1 is primarily expressed in normal endothelial cells, dysregulated ESM1 expression has been observed in human tumors and animal tumor models, and implicated in tumor growth, metastasis and angiogenesis. The precise role of ESM1 in tumor angiogenesis and its potential regulatory mechanisms are not yet conclusively defined. However, the aim of the present review was to explore the involvement of ESM1 in the process of tumor angiogenesis in the TME and the characteristics of neovascularization. In addition, the present review discusses the interaction between ESM1 and angiogenic factors, as well as the mechanisms through which ESM1 contributes to tumor angiogenesis. Furthermore, the reciprocal regulation between ESM1 and the TME is explored. Finally, the potential of targeting ESM1 as a therapeutic strategy for tumor angiogenesis is presented.

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The Plasma Levels of the Angiogenic Cytokine Endocan Are Elevated in Patients with Multiple Myeloma

Abstract: The plasma levels of endocan can non-invasively differentiate patients newly diagnosed with MM from those with MGUS and should therefore be evaluated prospectively as a potential diagnostic marker.

Cited by 6 publications

References 14 publications

Diagnostic and Prognostic Value of Serum Endocan Levels in Patients With COVID-19

Diagnostic and Prognostic Value of Serum Endocan Levels in Patients With COVID-19

Increased Carotid Intima–Media Thickness and Endothelial Cell-Specific Molecule-1 (Endocan) Levels in Obese Children

Roles of endothelial cell specific molecule‑1 in tumor angiogenesis (Review)

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