The Plant Natural Products: Their Antioxidants, Free Radical Scavengers, DNA Protection and Antimicrobial Activities

Abdel-lateif, Khalid S.; Maghrabi, Ibrahim A.; Eldeab, Hany A.

doi:10.4172/2155-9821.1000293

Cited by 9 publications

(5 citation statements)

References 70 publications

(79 reference statements)

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“…Large single spots were rarely seen but their frequency was also highest in samples treated with H 2 O 2 (Table 2). These results showed that ethanol and methanol extracts of L. iberica prevented somatic mutations, which could occur because of the hydroxy radicals that can react with purine and pyrimidine bases and the deoxyribose backbone, resulting in various harmful products such as 8‐oxo‐7,8‐dehydro‐2‐deoxyguanosine, hydroxymethyl urea, thymine glycol, thymine and opened adenine ring 62 . When the extracts were co‐administered with H 2 O 2 , highest inhibitions were observed in twin spots (Table 3).…”

Section: Resultsmentioning

confidence: 94%

Cytoprotective, antimutagenic/antirecombinogenic and antibacterial properties of Lallemantia iberica extracts

et al. 2022

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BACKGROUND Plants have important chemical compounds to protect organisms from many mutagens but they may also have dangerous toxic substances that must be tested before use. Lallemantia iberica has been used by local people for treatment of some diseases but it was never tested for its cell protective and antimutagenic/antirecombinogenic properties. In this study, it was aimed to determine the cytoprotective, antimutagenic/antirecombinogenic, antibacterial, antioxidant and phenolic profile of L. iberica by MTS assay, micronucleus test/somatic mutation recombination test (SMART), disc diffusion method, ABTS/DPPH tests and liquid chromatography (LC), respectively. RESULTS MTS assay results showed that both of the extracts supported the normal growth of healthy human lymphocytes and there was no significant difference between extracts. Although there was no significant increase in micronucleus concentration (‰) of the cultures treated with ethanol or methanol extracts, methanol extract caused slightly lower micronucleus concentration (12.64 ± 3.65‰) than the ethanol extract (24.46 ± 4.50‰). SMART results showed that ethanol and methanol extracts prevented harmful mitotic recombination. Lallemantia iberica also showed antibacterial activity against all of the strains tested, and the largest inhibition zones were observed with Pseudomonas aeruginosa (17.9 mm) and Enterobacter aerogenes (13.8 mm). Methanol extracts showed better antioxidant activities (ABTS IC50: 104.07 μg mL−1, DPPH IC50: 58.8 μg mL−1) than ethanol extracts (ABTS IC50: 344.03 μg mL−1, DPPH IC50: 233.7 μg mL−1). According to the LC results, the most abundant phenolic compounds were rutin hydrate (1796.4 ± 62.9 mg kg−1) and p‐coumaric acid (228.1 ± 7.60 mg kg−1). CONCLUSION Lallemantia iberica extracts had cell‐protective, antimutagenic/antirecombinogenic, antibacterial and strong antioxidant characteristics in relation to their rich phenolic content. © 2022 Society of Chemical Industry.

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Section: Resultsmentioning

confidence: 94%

Cytoprotective, antimutagenic/antirecombinogenic and antibacterial properties of Lallemantia iberica extracts

et al. 2022

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“…One of the main damages caused by prolonged water stress is the production of reactive oxygen species (ROS), which will ultimately interfere in the structure of biomolecules and jeopardize overall plant physiology [42,43]. Therefore, the production of essential oils may represent a biochemical defense, as several terpenes present significant antioxidant activities [44,45].…”

Section: Essential Oil Content (%)mentioning

confidence: 99%

Chemical Composition and Antioxidant Activity of Essential Oils from Populations of Baccharis dracunculifolia DC. in Southern Brazil

Tomazzoli

Amaral

Cipriano

et al. 2021

Braz. arch. biol. technol.

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Baccharis dracunculifolia DC. is a Brazilian native plant, presenting wide chemical diversity and numerous pharmaceutical and industrial applications. This research assessed the yield, antioxidant activity and the chemical similarity of essential oils from 10 populations of B. dracunculifolia in the state of Paraná, southern Brazil. The extraction of the volatile compounds was carried out by hydrodistillation, the chemical composition was determined by GC/FID and GC/MS and the antioxidant activity by the DPPH method. The essential oil yield of wild B. dracunculifolia populations ranged from 0.14 to 0.87%. The oils were predominantly composed of oxygenated sesquiterpenes (34.16 -51.01%), monoterpene hydrocarbons (18.02 -46.17%) and sesquiterpenes hydrocarbons (9.60 -17.70%). The major compounds found in all populations were β-pinene (7.65 -29.8%) and (E)-nerolidol (9.11 -21.68%). Essential oil solutions (20%) from different populations presented antioxidant capacity ranging from 27.78 to 91.67%. A negative correlation was found between the antioxidant activity and spathulenol (r = -0.696). Multivariate analyses HIGHLIGHTS  Essential oils from populations of B. dracunculifolia were investigated.  β-pinene and (E)-nerolidol were the main compounds in B. dracunculifolia populations.  The difference in the chemical profile of the essential oils is quantitative only. There is a negative correlation between the antioxidant activity and spathulenol.Tomazzoli, M.M.; et al.

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“…[ 1 ] To date, 60% of new anti‐cancer drugs and 75% of new drugs for infectious diseases are derived from natural products. [ 2 ] Plants are rich in a variety of bioactive components such as flavonoids, polyphenols, alkaloids, polysaccharides, volatile oils, quinones, terpenoids, lignans, coumarins, saponins, and cardiac glycosides, [ 3 ] but the content is not high, in particular, there are many structurally similar components, even enantiomers or non‐enantiomers, usually with different biological activities. These different structural types of compounds make it a large library of natural compounds.…”

Section: Introductionmentioning

confidence: 99%

Application of Molecularly Imprinted Polymers in Plant Natural Products: Current Progress and Future Perspectives

Zuo

et al. 2022

Macro Materials & Eng

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Plants, as a large and complex system, are rich in a variety of natural bioactive constituents. It is crucial to enrich, isolate, purify and detect these natural products. Molecularly imprinted polymers (MIPs) are a class of polymers prepared by molecularly imprinted technology (MIT) that have specific recognition sites and are complementary to templates in shape, size, and binding groups. The synthesis and polymerization mechanism of MIPs are introduced. A variety of preparation methods for MIPs have been developed. MIPs can be classified into three types: non-covalent molecularly imprinted, covalent molecularly imprinted, and semi-covalent molecularly imprinted. MIPs usually consists of five parts: template, functional monomer, cross-linker, initiator, and solvent/reagent. With the advantages of high-specificity binding ability, MIPs have shown excellent efficacy in the separation, enrichment, and purification of plant active products, such as flavonoids, polyphenols, terpenoids, and other components, especially as specific adsorbent materials. Due to the high selectivity to target the analytes, MIPs have also been used as sensors to detect the bioactive constituents in plants. Undeniably, MIPs still face undeniable limitations in the application of plant natural products. The development of MIPs with high selectivity, strong affinity, cost-effectiveness, sensitivity, and environmental friendliness are valuable and promising.

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The Plant Natural Products: Their Antioxidants, Free Radical Scavengers, DNA Protection and Antimicrobial Activities

Cited by 9 publications

References 70 publications

Cytoprotective, antimutagenic/antirecombinogenic and antibacterial properties of Lallemantia iberica extracts

Cytoprotective, antimutagenic/antirecombinogenic and antibacterial properties of Lallemantia iberica extracts

Chemical Composition and Antioxidant Activity of Essential Oils from Populations of Baccharis dracunculifolia DC. in Southern Brazil

Application of Molecularly Imprinted Polymers in Plant Natural Products: Current Progress and Future Perspectives

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