The placebo effect, sleep difficulty, and side effects: a balanced placebo model

Neukirch, Nadine; Colagiuri, Ben

doi:10.1007/s10865-014-9590-5

Cited by 31 publications

(23 citation statements)

References 43 publications

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“…Importantly the Bayes Factor of 4.78 in favour of the null hypothesis, rather than simply the failure to find an effect, constitutes substantial evidence that genetic information does not affect caffeine withdrawal. Some results in the placebo field using priming manipulations have yielded remarkable results, such as lowering body-mass index and blood pressure 40 and producing differences in ghrelin secretion 41 , 42 . Not surprisingly, such findings have drawn considerable attention.…”

Section: Discussionmentioning

confidence: 99%

Effect of Genetic Information and Information About Caffeine Content on Caffeine Withdrawal Symptoms

Mills

Dar‐Nimrod

Colagiuri

2017

Sci Rep

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This study sought to test the effect of genetic information and information about the caffeine content of a beverage on caffeine withdrawal, specifically if: (1) being informed that one has tested positive for a gene related to caffeine withdrawal can produce an exaggerated caffeine withdrawal response during abstinence; (2) belief that one has consumed caffeine leads to a reduction in withdrawal symptoms when no caffeine is consumed. Regular coffee drinkers were given a bogus genetic test and were told either that they had tested positive or negative for a gene related to withdrawal. After 24-hour caffeine abstinence withdrawal symptoms were measured using a self-report caffeine withdrawal scale, and then again after a cup of decaffeinated coffee. Half the participants were told their coffee was caffeinated and half were told truthfully that it was decaffeinated. Participants told the coffee was caffeinated reported a greater reduction in withdrawal symptoms than those told it was decaffeinated. Differing genetic test result information produced no difference in reported withdrawal symptoms. These results indicate that information about the dose of caffeine administered can influence withdrawal symptoms, but that genetic information does not have a universal ability to produce nocebo effects across all sensory and cognitive domains.

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Section: Discussionmentioning

confidence: 99%

Effect of Genetic Information and Information About Caffeine Content on Caffeine Withdrawal Symptoms

Mills

Dar‐Nimrod

Colagiuri

2017

Sci Rep

Self Cite

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“…In two experimental studies, participants were informed that they were taking a new hypnotic medication to improve their sleep quality (actually placebo). Participants received this placebo treatment in conjunction with a warning that they might experience change in appetite as a side effect (Colagiuri, McGuinness, Boakes, & Butow, ; Neukirch & Colagiuri, ). One group was warned that they might experience an increase in appetite, while the other was warned that their appetite might decrease as a side effect of the medication.…”

Section: Mechanisms Underlying Nocebo Effectsmentioning

confidence: 99%

Nocebo effects in health psychology

Faasse

2019

Australian Psychologist

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The nocebo effect is a potentially powerful phenomenon that can result in harmful or unpleasant treatment outcomes caused by negative expectations, past experience, and other aspects of the treatment context. These aversive outcomes can cause patients to discontinue an otherwise beneficial treatment-resulting in suboptimal health outcomes, added burden of illness, reduced quality of life, and unnecessary hospitalisations, medical consultations, and increased cost for both the patient and the health care system. Much research to date has focused on the role of negative expectations in nocebo effects; this review also emphasises the more overlooked mechanisms of anxiety and classical conditioning, and how these might be usefully targeted to reduce nocebo effects. The evidence for each of these mechanisms, and their potential interactions, is reviewed. Regardless of how they develop, nocebo effects can contribute substantially to the overall burden of treatment side effects, and an overview of evidence-based interventions to reduce nocebo effects by targeting each of the underlying mechanisms is presented. Currently, no strategies are systematically applied to reduce nocebo effects, and most interventions have yet to be translated from experimental laboratory research into applied clinical settings. Future work should focus on developing and testing theoretically-based interventions to reduce nocebo effects, and on translating findings from lab-based studies into clinical practice and healthcare policy. K E Y W O R D S anxiety, classical conditioning, negative expectations, nocebo, side effects

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“…Nocebo effects are a particular concern in terms of treatment side effects, with experimental models demonstrating that warnings about side effects can increase side effect occurrence (e.g. Colagiuri et al, 2012, Neukirch and Colagiuri, 2015), thereby raising questions about informed consent and the best way to frame side effect warnings (Colloca and Miller, 2011b, Colloca and Finniss, 2012). Furthermore, the clinical relevance of these nocebo-induced side effects is highlighted by the fact that expectancies often predict the severity of side effects, even for invasive treatments such as chemotherapy (Montgomery and Bovbjerg, 2000, Olver et al, 2005, Zachariae et al, 2007, Colagiuri et al, 2008, Colagiuri and Zachariae, 2010, Roscoe et al, 2010, Colagiuri et al, 2012).…”

Section: Historical and Pioneering Studies On The Placebo Effectmentioning

confidence: 99%

The placebo effect: From concepts to genes

et al. 2015

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Despite its initial treatment as a nuisance variable, the placebo effect is now recognized as a powerful determinant of health across many different diseases and encounters. This is in light of some remarkable findings ranging from demonstrations that the placebo effect significantly modulates the response to active treatments in conditions such as pain, anxiety, Parkinson’s disease, and some surgical procedures. Here, we review pioneering studies and recent advances in behavioral, neurobiological, and genetic influences on the placebo effect. Based on a previous developed conceptual framework, the placebo effect is presented as the product of a general expectancy learning mechanism in which verbal, conditioned and social cues are centrally integrated to change behaviors and outcomes. Examples of the integration of verbal and conditioned cues, such as instructed reversal of placebo effects are also incorporated into this model. We discuss neuroimaging studies that using well-established behavioral paradigms have identified key brain regions and modulatory mechanisms underlying placebo effects. Finally, we present a synthesis of recent genetics studies on the placebo effect, highlighting a promising link between genetic variants in the dopamine, opioid, serotonin, and endocannabinoid pathways and placebo responsiveness. Greater understanding of the behavioral, neurobiological, and genetic influences on the placebo effect is critical for evaluating medical interventions and may allow health professionals to tailor and personalize interventions in order to maximize treatment outcomes in clinical settings.

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The placebo effect, sleep difficulty, and side effects: a balanced placebo model

Cited by 31 publications

References 43 publications

Effect of Genetic Information and Information About Caffeine Content on Caffeine Withdrawal Symptoms

Effect of Genetic Information and Information About Caffeine Content on Caffeine Withdrawal Symptoms

Nocebo effects in health psychology

The placebo effect: From concepts to genes

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