COVID-19 is the respiratory disease caused by the new coronavirus SARS-CoV-2 and is characterized by clinical manifestations ranging from mild, flu-like symptoms to severe respiratory and multi-organ failure. Patients with more severe symptoms may require intensive care treatments and face a high risk of mortality. COVID 19 is characterized by an abnormal inflammatory response similar to a cytokine storm, which is associated with endothelial dysfunction and microvascular complications. To date, no specific treatments are available for COVID-19 and its potentially life-threatening complications.Ozonetherapy is the administration of a mixture of ozone and oxygen (MO), which produces a series of benefits capable of counteracting a wide range of pathologies, in use for over a century as an unconventional medicine practice.Ozonetherapy using the techniques of small self-emo-infusion, and the topical application of ozonated oils or irrigation with ozonated water at the nasal level, could help to enhance the innate immune response at the level of the entrance ports in order to decrease the viral load and slow viral growth, especially in the early stages. In fact, recent studies show that nasal transport is likely to be a key feature of transmission, and drugs / vaccines administered intranasally could be highly effective in limiting spread.