Ozonetherapy: a multirole weapon,  topical pathway against SARS-COV-2

Ranaldi, Giovanni Tommaso; Villani, Emanuele Rocco; Franza, Laura; Motola, Giulia

doi:10.31226/osf.io/n2dup

Cited by 3 publications

(3 citation statements)

References 27 publications

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“…O 3 is a strong oxidizing agent and can thus be used to disinfect viral infection [71]. Ozonation could result in a decrease in viral load [72].…”

Section: Ozone Therapymentioning

confidence: 99%

A Systematic Biomedical Perspective on COVID-19 Pandemic: From Detection to Vaccination

Mir¹,

Wani²,

John³

et al. 2021

Advanced Chemicobiology Research

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The year 2020 witnessed a challenging period for worldwide scientists to find a suitable treatment for the deadly novel coronavirus infectious disease-2019 (nCOVID or COVID-19). The entire scientific community has been eager to develop effective vaccines and medicine against COVID-19. Despite the fact of administration of vaccination in several countries across the globe, the drug repurposing of several antiviral compounds yielded satisfactory results in recovering the affected people. As it is a known fact that vaccination alone is not the end of this pandemic, but the final treatment in terms of drugs/medicines specific to this disease is yet underway. It looks worthy to present a literature survey based on the collective information related to the drug candidates that have been repurposed, the respective theoretical evaluation, and some of the effective therapies usable in treating COVID-19. This review also describes diagnosis and vaccination availed so far. Therefore, a sequential literature extract is hereby presented starting from the detection, going through virulence, drug repositioning, virtual screening, and the final destination in the form of vaccine development. A few commercially available vaccines have also been introduced. Based on the survey, it is clear that the entire world must remain alert for any future pandemic keeping in view the successful and unsuccessful efforts practiced in the COVID-19 pandemic.

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“…O 3 is a strong oxidizing agent and can thus be used to disinfect viral infection [71]. Ozonation could result in a decrease in viral load [72].…”

Section: Ozone Therapymentioning

confidence: 99%

A Systematic Biomedical Perspective on COVID-19 Pandemic: From Detection to Vaccination

Mir¹,

Wani²,

John³

et al. 2021

Advanced Chemicobiology Research

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show abstract

“… 56 Therefore, SARS-CoV-2 could potentially be inactivated by ozone-mediated oxidation during the viremic phase (if administered early via auto-hemo-infusion) and at the level of the colonized nasopharyngeal mucosa of healthy carriers through topic formulations. 57 …”

Section: O Zone In Covid-19mentioning

confidence: 99%

Rationale for ozone-therapy as an adjuvant therapy in COVID-19: a narrative review

2020

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Coronavirus disease 2019 (COVID-19) is the respiratory disease caused by the novel severe acute respiratory syndrome-coronavirus-2 and is characterized by clinical manifestations ranging from mild, flu-like symptoms to severe respiratory insufficiency and multi-organ failure. Patients with more severe symptoms may require intensive care treatments and face a high mortality risk. Also, thrombotic complications such as pulmonary embolisms and disseminated intravascular coagulation are frequent in these patients. Indeed, COVID-19 is characterized by an abnormal inflammatory response resembling a cytokine storm, which is associated to endothelial dysfunction and microvascular complications. To date, no specific treatments are available for COVID-19 and its life-threatening complication. Immunomodulatory drugs, such as hydroxychloroquine and interleukin-6 inhibitors, as well as antithrombotic drugs such as heparin and low molecular weight heparin, are currently being administered with some benefit. Ozone therapy consists in the administration of a mixture of ozone and oxygen, called medical ozone, which has been used for over a century as an unconventional medicine practice for several diseases. Medical ozone rationale in COVID-19 is the possibility of contrasting endothelial dysfunction, modulating the immune response and acting as a virustatic agent. Thus, medical ozone could help to decrease lung inflammation, slow down viral growth, regulate lung circulation and oxygenation and prevent microvascular thrombosis. Ozone-therapy could be considered a feasible, cost-effective and easy to administer adjuvant therapy while waiting for the synthesis of a therapy or the development of the vaccine.

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“…Finally, in particular cases, the use of the ozone-dilution technique in physiological solution and its infusion could also be evaluated and, in the future, the possibility of using ozone therapy with endonasal insufflation as a substitute for the vaccine could be evaluated [43].…”

Section: Sars-cov-2 and Intestinementioning

confidence: 99%

Ozonetherapy vs SARS-COV-2 in gut: the fountainhead

Ranaldi¹,

Villani²,

Franza³

et al. 2020

Preprint

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COVID-19 is the disease caused by the new coronavirus SARS-CoV-2 and is characterized by clinical manifestations ranging from mild, flu-like symptoms, to severe respiratory failure and multi-organ failure. Patients with more severe symptoms may require intensive care treatments and face a high risk of mortality.COVID 19 is characterized by an abnormal inflammatory response similar to a cytokine storm, which is associated with endothelial dysfunction and microvascular complications. To date, no specific treatments are available for COVID-19 and its potentially life-threatening complications.Numerous experimental and clinical observations have suggested that the gut microbiota plays a key role in sepsis and ARDS pathogenesis. The incidence of diarrhea in COVID-19 patients and the high mortality rate in elderly patients, considered together, indicate a possible involvement of the intestine-lung axis in COVID-19 with association of dysbiosis.Ozonetherapy is the administration of a mixture of ozone and oxygen, or Medical Ozone (MO), which produces a series of benefits capable of counteracting a wide range of pathologies, in use for over a century as an unconventional medicine practice.MO is fundamental to inhibit the activation of the inflammatory reaction and to obtain an antioxidant activity both in the tissue and in the blood. Oxidative ozone preconditioning causes an increase in SOD, GSH-Px values.MO, using large auto-hemo-infusion or rectal insufflation technique or ozonized water, could help oxygenate the tissues better, decrease gut inflammation and regulate immune response, help slow down viral growth, regulate circulation and avoid or slow down vascular hypertrophy and consequent hyperemia , especially in the early stages, with obvious benefit at microbiome level.

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Ozonetherapy: a multirole weapon, topical pathway against SARS-COV-2

Cited by 3 publications

References 27 publications

A Systematic Biomedical Perspective on COVID-19 Pandemic: From Detection to Vaccination

A Systematic Biomedical Perspective on COVID-19 Pandemic: From Detection to Vaccination

Rationale for ozone-therapy as an adjuvant therapy in COVID-19: a narrative review

Ozonetherapy vs SARS-COV-2 in gut: the fountainhead

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